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Article: A haplotype map of the human genome

TitleA haplotype map of the human genome
Authors
Belmont, JWBoudreau, ALeal, SMHardenbol, PPasternak, SWheeler, DAWillis, TDYu, FYang, HGao, YHu, HWang, YWang, YXiong, XXu, LWaye, MMYTsui, SKWXue, HWong, JTFGalver, LMBarrett, JSodergren, EFan, JBMurray, SSOliphant, ARChee, MSMontpetit, AChagnon, FFerretti, VLeboeuf, MOlivier, JFPhillips, MSWeinstock, GMFry, BRoumy, SSallée, CVerner, AHudson, TJFrazer, KABallinger, DGCox, DRHinds, DAStuve, LLYakub, IKwok, PYHu, WCai, DKoboldt, DCMiller, RDPawlikowska, LTaillonMiller, PXiao, MTsui, LCMak, WGabriel, SBSham, PCSong, YQMaller, JTam, PKHNakamura, YKawaguchi, TKitamoto, TMorizono, TNagashima, AOhnishi, YOnofrio, RCSekine, ATanaka, TDeloukas, PMcCarroll, SBird, CPDelgado, MDermitzakis, ETPatterson, NPe'er, IPurcell, SZiaugra, LRichter, DJSabeti, PSaxena, RSchaffner, SFVarilly, PLi, CStein, LDKrishnan, LSmith, AVThorisson, GABirren, BWChakravarti, AChen, PECutler, DJKashuk, CSLin, SAbecasis, GRLin, WGuan, WMunro, HMQin, ZSDaly, MJThomas, DJMcVean, GBottolo, LEyheramendy, SFreeman, CMarchini, JMyers, SLiu, SSpencer, CStephens, MWilson, RKDonnelly, PCardon, LRClarke, GEvans, DMMorris, APWeir, BSTsunoda, TMullikin, JCPan, HSherry, STYu, JFeolo, MZhang, HZeng, CZhao, HMatsuda, IFukushima, YMacer, DRSuda, ERotimi, CNTang, XGwilliam, RAdebamowo, CAAjayi, IAniagwu, TMarshall, PANkwodimmah, CRoyal, CDMLeppert, MFDixon, MPeiffer, AQiu, RFulton, LLWang, JKent, AKato, KNiikawa, NAdewole, IFKnoppers, BMFoster, MWClayton, EWWatkin, JGibbs, RARogers, JMuzny, DWang, WNazareth, LBurton, JCarter, NPClee, CMGriffiths, MJones, MCMcLay, KPlumb, RWRoss, MTHunt, SZhang, BSims, SKWilley, DLChen, ZHan, HKang, LGodbout, MWallenburg, JCL'Archevêque, PBellemare, GMorrison, JSaeki, KZhang, QWang, HAn, DFu, HLi, QWang, ZWang, RHolden, ALBrooks, LDPowell, DMcEwen, JEBird, CRZhao, HGuyer, MSNailer, PJWang, VOPeterson, JLShi, MSpiegel, JSung, LMStranger, BEWitonsky, JZacharia, LFCollins, FSZhou, JKennedy, KJamieson, RStewart, JBarry, RBlumenstiel, BCamargo, AWhittaker, PDefelice, MFaggart, MGoyette, MGupta, SMoore, JNguyen, HParkin, MRoy, JStahl, EWinchester, EBentley, DRAltshuler, DShen, YYao, ZHuang, WChu, XHe, YJin, LLiu, YShen, YSun, WDe Bakker, PIWWang, H
Issue Date2005
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
Citation
Nature, 2005, v. 437 n. 7063, p. 1299-1320 How to Cite?
AbstractInherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million single nucleotide polymorphisms (SNPs) for which accurate and complete genotypes have been obtained in 269 DNA samples from four populations, including ten 500-kilobase regions in which essentially all information about common DNA variation has been extracted. These data document the generality of recombination hotspots, a block-like structure of linkage disequilibrium and low haplotype diversity, leading to substantial correlations of SNPs with many of their neighbours. We show how the HapMap resource can guide the design and analysis of genetic association studies, shed light on structural variation and recombination, and identify loci that may have been subject to natural selection during human evolution. © 2005 Nature Publishing Group.
Persistent Identifierhttp://hdl.handle.net/10722/81471
ISSN
2023 Impact Factor: 50.5
2023 SCImago Journal Rankings: 18.509
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBelmont, JWen_HK
dc.contributor.authorBoudreau, Aen_HK
dc.contributor.authorLeal, SMen_HK
dc.contributor.authorHardenbol, Pen_HK
dc.contributor.authorPasternak, Sen_HK
dc.contributor.authorWheeler, DAen_HK
dc.contributor.authorWillis, TDen_HK
dc.contributor.authorYu, Fen_HK
dc.contributor.authorYang, Hen_HK
dc.contributor.authorGao, Yen_HK
dc.contributor.authorHu, Hen_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorWang, Yen_HK
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dc.contributor.authorXu, Len_HK
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dc.contributor.authorWong, JTFen_HK
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dc.contributor.authorZhao, Hen_HK
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dc.contributor.authorFukushima, Yen_HK
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dc.date.accessioned2010-09-06T08:18:10Z-
dc.date.available2010-09-06T08:18:10Z-
dc.date.issued2005en_HK
dc.identifier.citationNature, 2005, v. 437 n. 7063, p. 1299-1320en_HK
dc.identifier.issn0028-0836en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81471-
dc.description.abstractInherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million single nucleotide polymorphisms (SNPs) for which accurate and complete genotypes have been obtained in 269 DNA samples from four populations, including ten 500-kilobase regions in which essentially all information about common DNA variation has been extracted. These data document the generality of recombination hotspots, a block-like structure of linkage disequilibrium and low haplotype diversity, leading to substantial correlations of SNPs with many of their neighbours. We show how the HapMap resource can guide the design and analysis of genetic association studies, shed light on structural variation and recombination, and identify loci that may have been subject to natural selection during human evolution. © 2005 Nature Publishing Group.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/natureen_HK
dc.relation.ispartofNatureen_HK
dc.subject.meshChromosomes, Human, Y - genetics-
dc.subject.meshDNA, Mitochondrial - genetics-
dc.subject.meshGenome, Human-
dc.subject.meshHaplotypes - genetics-
dc.subject.meshPolymorphism, Single Nucleotide - genetics-
dc.titleA haplotype map of the human genomeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0028-0836&volume=437&issue=7063&spage=1299&epage=1320&date=2005&atitle=A+haplotype+map+of+the+human+genome+(Co-PI+of+Hong+Kong+Centre+which+responsible+for+2.5%+of+genome)en_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailSong, YQ: songy@hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hku.hken_HK
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dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/nature04226en_HK
dc.identifier.pmid16255080-
dc.identifier.pmcidPMC1880871-
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dc.identifier.volume437en_HK
dc.identifier.issue7063en_HK
dc.identifier.spage1299en_HK
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dc.identifier.scopusauthoridWang, H=35275993000en_HK
dc.identifier.citeulike366486-
dc.identifier.issnl0028-0836-

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