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Article: Role of potassium in regulating blood flow and blood pressure

TitleRole of potassium in regulating blood flow and blood pressure
Authors
KeywordsEndothelium-derived hyperpolarization factor
Na+-K +-ATPase
Potassium channels
Issue Date2006
PublisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpregu.physiology.org
Citation
American Journal Of Physiology - Regulatory Integrative And Comparative Physiology, 2006, v. 290 n. 3, p. R546-R552 How to Cite?
AbstractUnlike sodium, potassium is vasoactive; for example, when infused into the arterial supply of a vascular bed, blood flow increases. The vasodilation results from hyperpolarization of the vascular smooth muscle cell subsequent to potassium stimulation by the ion of the electrogenic Na+-K + pump and/or activating the inwardly rectifying Kir channels. In the case of skeletal muscle and brain, the increased flow sustains the augmented metabolic needs of the tissues. Potassium ions are also released by the endothelial cells in response to neurohumoral mediators and physical forces (such as shear stress) and contribute to the endothelium-dependent relaxations, being a component of endothelium-derived hyperpolarization factor-mediated responses. Dietary supplementation of potassium can lower blood pressure in normal and some hypertensive patients. Again, in contrast to NaCl restriction, the response to potassium supplementation is slow to appear, taking ∼4 wk. Such supplementation reduces the need for antihypertensive medication. "Salt-sensitive" hypertension responds particularly well, perhaps, in part, because supplementation with potassium increases the urinary excretion of sodium chloride. Potassium supplementation may even reduce organ system complications (e.g., stroke). Copyright © 2006 the American Physiological Society.
Persistent Identifierhttp://hdl.handle.net/10722/80308
ISSN
2023 Impact Factor: 2.2
2023 SCImago Journal Rankings: 0.904
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHaddy, FJen_HK
dc.contributor.authorVanhoutte, PMen_HK
dc.contributor.authorFeletou, Men_HK
dc.date.accessioned2010-09-06T08:04:52Z-
dc.date.available2010-09-06T08:04:52Z-
dc.date.issued2006en_HK
dc.identifier.citationAmerican Journal Of Physiology - Regulatory Integrative And Comparative Physiology, 2006, v. 290 n. 3, p. R546-R552en_HK
dc.identifier.issn0363-6119en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80308-
dc.description.abstractUnlike sodium, potassium is vasoactive; for example, when infused into the arterial supply of a vascular bed, blood flow increases. The vasodilation results from hyperpolarization of the vascular smooth muscle cell subsequent to potassium stimulation by the ion of the electrogenic Na+-K + pump and/or activating the inwardly rectifying Kir channels. In the case of skeletal muscle and brain, the increased flow sustains the augmented metabolic needs of the tissues. Potassium ions are also released by the endothelial cells in response to neurohumoral mediators and physical forces (such as shear stress) and contribute to the endothelium-dependent relaxations, being a component of endothelium-derived hyperpolarization factor-mediated responses. Dietary supplementation of potassium can lower blood pressure in normal and some hypertensive patients. Again, in contrast to NaCl restriction, the response to potassium supplementation is slow to appear, taking ∼4 wk. Such supplementation reduces the need for antihypertensive medication. "Salt-sensitive" hypertension responds particularly well, perhaps, in part, because supplementation with potassium increases the urinary excretion of sodium chloride. Potassium supplementation may even reduce organ system complications (e.g., stroke). Copyright © 2006 the American Physiological Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpregu.physiology.orgen_HK
dc.relation.ispartofAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiologyen_HK
dc.subjectEndothelium-derived hyperpolarization factoren_HK
dc.subjectNa+-K +-ATPaseen_HK
dc.subjectPotassium channelsen_HK
dc.titleRole of potassium in regulating blood flow and blood pressureen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0363-6119&volume=290&spage=R546&epage=R552&date=2005&atitle=Role+of+potassium+in+regulating+blood+flow+and+blood+pressureen_HK
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_HK
dc.identifier.authorityVanhoutte, PM=rp00238en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1152/ajpregu.00491.2005en_HK
dc.identifier.pmid16467502-
dc.identifier.scopuseid_2-s2.0-33645388656en_HK
dc.identifier.hkuros119390en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645388656&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume290en_HK
dc.identifier.issue3en_HK
dc.identifier.spageR546en_HK
dc.identifier.epageR552en_HK
dc.identifier.isiWOS:000235210300009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHaddy, FJ=7006109413en_HK
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_HK
dc.identifier.scopusauthoridFeletou, M=7006461826en_HK
dc.identifier.issnl0363-6119-

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