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- Publisher Website: 10.1016/S0014-2999(99)00438-0
- Scopus: eid_2-s2.0-0032780428
- PMID: 10478565
- WOS: WOS:000081841700008
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Article: Progesterone modulates estradiol actions: Acute effects at physiological concentrations
Title | Progesterone modulates estradiol actions: Acute effects at physiological concentrations |
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Authors | |
Keywords | 17β-Estradiol Coronary artery Porcine Progesterone Vasorelaxation |
Issue Date | 1999 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar |
Citation | European Journal Of Pharmacology, 1999, v. 378 n. 1, p. 57-62 How to Cite? |
Abstract | The progestin element of hormone replacement therapy may reduce the cardioprotective actions of the estrogen component. Only high concentrations (μM) of progesterone directly relaxed U46619 (9,11-dideoxy-9α, 11α-methanoepoxy prostaglandin F2α)-pre-contracted porcine coronary artery rings. A low concentration of progesterone (1 nM), with no effects of its own, shifted the relaxation curves of bradykinin and calcium ionophore A23187 to the right while not affecting those of sodium nitroprusside and levcromakalim. The negative influence that 1 nM progesterone exerted on bradykinin- and A23187-mediated relaxation was diminished when 1 nM 17β-estradiol was concomitantly added to the bathing medium. Conversely, the potentiating actions of 1 nM 17β-estradiol on relaxations elicited by sodium nitroprusside and levcromakalim were reduced following simultaneous treatment with the same concentrations of progesterone. These findings represent the first evidence for an acute in vitro vascular effect of progesterone at a physiologically relevant concentration and concur with previous in vivo reports demonstrating that progesterone may diminish the beneficial effects of estrogens. Copyright (C) 1999 Elsevier Science B.V. |
Persistent Identifier | http://hdl.handle.net/10722/80220 |
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 1.055 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Teoh, H | en_HK |
dc.contributor.author | Man, RYK | en_HK |
dc.date.accessioned | 2010-09-06T08:03:52Z | - |
dc.date.available | 2010-09-06T08:03:52Z | - |
dc.date.issued | 1999 | en_HK |
dc.identifier.citation | European Journal Of Pharmacology, 1999, v. 378 n. 1, p. 57-62 | en_HK |
dc.identifier.issn | 0014-2999 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/80220 | - |
dc.description.abstract | The progestin element of hormone replacement therapy may reduce the cardioprotective actions of the estrogen component. Only high concentrations (μM) of progesterone directly relaxed U46619 (9,11-dideoxy-9α, 11α-methanoepoxy prostaglandin F2α)-pre-contracted porcine coronary artery rings. A low concentration of progesterone (1 nM), with no effects of its own, shifted the relaxation curves of bradykinin and calcium ionophore A23187 to the right while not affecting those of sodium nitroprusside and levcromakalim. The negative influence that 1 nM progesterone exerted on bradykinin- and A23187-mediated relaxation was diminished when 1 nM 17β-estradiol was concomitantly added to the bathing medium. Conversely, the potentiating actions of 1 nM 17β-estradiol on relaxations elicited by sodium nitroprusside and levcromakalim were reduced following simultaneous treatment with the same concentrations of progesterone. These findings represent the first evidence for an acute in vitro vascular effect of progesterone at a physiologically relevant concentration and concur with previous in vivo reports demonstrating that progesterone may diminish the beneficial effects of estrogens. Copyright (C) 1999 Elsevier Science B.V. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar | en_HK |
dc.relation.ispartof | European Journal of Pharmacology | en_HK |
dc.rights | European Journal of Pharmacology. Copyright © Elsevier BV. | en_HK |
dc.subject | 17β-Estradiol | en_HK |
dc.subject | Coronary artery | en_HK |
dc.subject | Porcine | en_HK |
dc.subject | Progesterone | en_HK |
dc.subject | Vasorelaxation | en_HK |
dc.title | Progesterone modulates estradiol actions: Acute effects at physiological concentrations | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-2999&volume=378&spage=57&epage=62&date=1999&atitle=Progesterone+modulates+estradiol+actions:+acute+effects+at+physiological+concentrations | en_HK |
dc.identifier.email | Man, RYK: rykman@hkucc.hku.hk | en_HK |
dc.identifier.authority | Man, RYK=rp00236 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/S0014-2999(99)00438-0 | en_HK |
dc.identifier.pmid | 10478565 | - |
dc.identifier.scopus | eid_2-s2.0-0032780428 | en_HK |
dc.identifier.hkuros | 50110 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0032780428&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 378 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 57 | en_HK |
dc.identifier.epage | 62 | en_HK |
dc.identifier.isi | WOS:000081841700008 | - |
dc.publisher.place | Netherlands | en_HK |
dc.identifier.scopusauthorid | Teoh, H=7003816542 | en_HK |
dc.identifier.scopusauthorid | Man, RYK=7004986435 | en_HK |
dc.identifier.issnl | 0014-2999 | - |