Change of bone mass and biomechancis influenced by exercise in ovariectomized rats

Abstract

Bone mineral density(BMD) of Ex-C group was higher than that in non-exercise Normal Control group. BMD of the E+Ca Group and that of Ex-Groups were significantly higher than that in OVX group. BMD in I-group was obviously lower than in all other groups. The result of biomechanic tests showed that : (1)No significant difference was observed between all 4 groups related with exercise and Normal group in the biomechanic parameters. (2)No significant difference was showed among all 4 groups related with exercise in all parameters. (3)BMD in H-group was not statistically different from that of Normal group, but biomechanic test showed that Flexibility in H-group was worse than in Normal group. (4)There was significant difference between I-group and all other groups in each parameter. Concludsion: Exercise showed independent effects on keeping bone mass and improving biomechanic nature during the growing stage and early or middle stage after ovarietomy.

目的：了解運動對切除卵巢大鼠骨密度（ＢＭＤ）和生物力學改變的影響。方法：４８只雌性大鼠隨機分組：①正常對照組；②骨質疏松模型組；③運動和服鈣聯合組，④運動 １組：去勢后即予以運動；⑤運動 ２組：去勢２月后才予以運動；⑥運動對照正常組；⑦制動組；⑧雌激素組。除①⑥組外，其余各組切除雙側卵巢。檢測各組骨密度和生物力學有關指標。結果：運動正常組ＢＭＤ高于非運動正常組；運動和鈣聯合組顯著高于模型組。制動組ＢＭＤ顯著低于各實驗組。生物力學實驗顯示：①運動各組的生物力學指標與正常組無顯著性差異；②運動各組之間的各項指標無顯著性差異；③激素組的ＢＭＤ與正常組無顯著差異，但生物力學試驗顯示韌性系數小；④運動組的各項指標與各運動實驗組有顯著性差異。結論：運動對大鼠生長期和去勢后早期和中期骨密度的提高和生物力學性能的改善有作用.