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Conference Paper: Resorbable metallic implant: finding from an animal model
Title | Resorbable metallic implant: finding from an animal model |
---|---|
Authors | |
Keywords | Resorbable Magnesium Implant Degradable Absorbable |
Issue Date | 2008 |
Publisher | Trans Tech Publications Ltd.. The Journal's web site is located at http://www.scitec.ch/1022-6680/ |
Citation | The 2008 International Conference on Multifunctional Materials and Structures, Hong Kong, China, 28-31 July 2008. In Advanced Materials Research, 2008, v. 47-50 pt. 1, p. 604-607 How to Cite? |
Abstract | Resorbable metallic implant of magnesium and its alloys had been studied since the 1900s. However, the excessive gas production resulted in its unpopularity after CoCr alloys and stainless steel were developed. With the advancement of alloying technologies, its use as a resorbable implant has re-emerged recently. Foreign researchers focused on the use of AZ-series and magnesium-rare earth metal alloys. However, the corrosion property of AZ-series alloys is unsatisfactory, and the effect of rare-earth metals on human is poorly studied. Therefore, we have investigated on the feasibility of using commercially available AM-series magnesium alloys. Previous researchers avoided this alloy series presumably because of the potential health effect of manganese, however our toxicological risk assessment revealed that the exposure level would be lower than the NOAEL (No Observable Adverse Effect Level), thus it is unlikely to cause any observable health effect on healthy individuals. Subcutaneous implantation of AM-series magnesium alloys into a mouse model for six months confirmed that, while all alloys tested showed slow corrosion and no observable in vivo toxicity, pitting corrosion did not occur for AM-series alloys but was frequent for AZ91D. This suggests that AM-series magnesium alloys are good candidates of resorbable metallic implants. © 2008 Trans Tech Publications. |
Description | Main Theme: Multi-functional Materials and Structures |
Persistent Identifier | http://hdl.handle.net/10722/79324 |
ISBN | |
ISSN | |
References |
DC Field | Value | Language |
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dc.contributor.author | Yuen, CK | en_HK |
dc.contributor.author | Ip, WY | en_HK |
dc.date.accessioned | 2010-09-06T07:53:23Z | - |
dc.date.available | 2010-09-06T07:53:23Z | - |
dc.date.issued | 2008 | en_HK |
dc.identifier.citation | The 2008 International Conference on Multifunctional Materials and Structures, Hong Kong, China, 28-31 July 2008. In Advanced Materials Research, 2008, v. 47-50 pt. 1, p. 604-607 | en_HK |
dc.identifier.isbn | 978-087849378-4 | - |
dc.identifier.issn | 1022-6680 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/79324 | - |
dc.description | Main Theme: Multi-functional Materials and Structures | - |
dc.description.abstract | Resorbable metallic implant of magnesium and its alloys had been studied since the 1900s. However, the excessive gas production resulted in its unpopularity after CoCr alloys and stainless steel were developed. With the advancement of alloying technologies, its use as a resorbable implant has re-emerged recently. Foreign researchers focused on the use of AZ-series and magnesium-rare earth metal alloys. However, the corrosion property of AZ-series alloys is unsatisfactory, and the effect of rare-earth metals on human is poorly studied. Therefore, we have investigated on the feasibility of using commercially available AM-series magnesium alloys. Previous researchers avoided this alloy series presumably because of the potential health effect of manganese, however our toxicological risk assessment revealed that the exposure level would be lower than the NOAEL (No Observable Adverse Effect Level), thus it is unlikely to cause any observable health effect on healthy individuals. Subcutaneous implantation of AM-series magnesium alloys into a mouse model for six months confirmed that, while all alloys tested showed slow corrosion and no observable in vivo toxicity, pitting corrosion did not occur for AM-series alloys but was frequent for AZ91D. This suggests that AM-series magnesium alloys are good candidates of resorbable metallic implants. © 2008 Trans Tech Publications. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Trans Tech Publications Ltd.. The Journal's web site is located at http://www.scitec.ch/1022-6680/ | en_HK |
dc.relation.ispartof | Advanced Materials Research | en_HK |
dc.subject | Resorbable | en_HK |
dc.subject | Magnesium | en_HK |
dc.subject | Implant | en_HK |
dc.subject | Degradable | en_HK |
dc.subject | Absorbable | en_HK |
dc.title | Resorbable metallic implant: finding from an animal model | en_HK |
dc.type | Conference_Paper | en_HK |
dc.identifier.email | Ip, WY: wyip@hku.hk | en_HK |
dc.identifier.authority | Ip, WY=rp00401 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.4028/www.scientific.net/AMR.47-50.604 | - |
dc.identifier.scopus | eid_2-s2.0-56349088785 | en_HK |
dc.identifier.hkuros | 166702 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-56349088785&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 47-50 | en_HK |
dc.identifier.issue | pt. 1 | - |
dc.identifier.spage | 604 | en_HK |
dc.identifier.epage | 607 | en_HK |
dc.publisher.place | Switzerland | en_HK |
dc.identifier.scopusauthorid | Ip, WY=35549641700 | en_HK |
dc.identifier.scopusauthorid | Yuen, CK=25823576300 | en_HK |
dc.customcontrol.immutable | sml 140807 | - |
dc.identifier.issnl | 1022-6680 | - |