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- Publisher Website: 10.1038/sj.bmt.1703144
- Scopus: eid_2-s2.0-0034824213
- PMID: 11571518
- WOS: WOS:000170808500018
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Article: Late onset post-transplantation lymphoproliferative disease of recipient origin following cytogenetic relapse and occult autologous haematopoietic regeneration after allogeneic bone marrow transplantation for acute myeloid leukaemia
Title | Late onset post-transplantation lymphoproliferative disease of recipient origin following cytogenetic relapse and occult autologous haematopoietic regeneration after allogeneic bone marrow transplantation for acute myeloid leukaemia |
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Authors | |
Keywords | Post-transplant lymphoproliferative disease Recipient origin |
Issue Date | 2001 |
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/bmt |
Citation | Bone Marrow Transplantation, 2001, v. 28 n. 4, p. 417-419 How to Cite? |
Abstract | A post-transplantation lymphoproliferative disease (PTLD) of recipient origin was identified in one of 376 consecutive cases of allogeneic bone marrow transplantation (BMT). This occurred in a 36-year-old woman who received an allogeneic BMT for acute myeloid leukaemia in relapse. At 15 months after BMT, recipient haematopietic and leukaemic cells were found in the bone marrow, which disappeared on withdrawal of immunosuppression. However, severe graft-versus-host disease (GVHD) necessitated the continuation of immunosuppression, leading to the occurrence of PTLD in the liver and lung 12 months afterwards. Fluorescence in situ hybridisation showed that the neoplastic cells were of recipient origin. Although the PTLD also responded completely to withdrawal of immuno-suppression, the patient finally died from the complications of GVHD. This case of late onset PTLD post-BMT showed features similar to those in solid organ transplantation, in that the tumour was of recipient origin and responded well to the withdrawal of immuno-suppression. Of further interest is that recipient lymphoid regeneration had accompanied autologous haematopoietic regeneration and become a target for subsequent neoplastic transformation. |
Persistent Identifier | http://hdl.handle.net/10722/77668 |
ISSN | 2023 Impact Factor: 4.5 2023 SCImago Journal Rankings: 1.318 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Au, WY | en_HK |
dc.contributor.author | Lie, AK | en_HK |
dc.contributor.author | Lee, CK | en_HK |
dc.contributor.author | Ma, SK | en_HK |
dc.contributor.author | Wan, TS | en_HK |
dc.contributor.author | Shek, TW | en_HK |
dc.contributor.author | Liang, R | en_HK |
dc.contributor.author | Kwong, YL | en_HK |
dc.date.accessioned | 2010-09-06T07:34:25Z | - |
dc.date.available | 2010-09-06T07:34:25Z | - |
dc.date.issued | 2001 | en_HK |
dc.identifier.citation | Bone Marrow Transplantation, 2001, v. 28 n. 4, p. 417-419 | en_HK |
dc.identifier.issn | 0268-3369 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/77668 | - |
dc.description.abstract | A post-transplantation lymphoproliferative disease (PTLD) of recipient origin was identified in one of 376 consecutive cases of allogeneic bone marrow transplantation (BMT). This occurred in a 36-year-old woman who received an allogeneic BMT for acute myeloid leukaemia in relapse. At 15 months after BMT, recipient haematopietic and leukaemic cells were found in the bone marrow, which disappeared on withdrawal of immunosuppression. However, severe graft-versus-host disease (GVHD) necessitated the continuation of immunosuppression, leading to the occurrence of PTLD in the liver and lung 12 months afterwards. Fluorescence in situ hybridisation showed that the neoplastic cells were of recipient origin. Although the PTLD also responded completely to withdrawal of immuno-suppression, the patient finally died from the complications of GVHD. This case of late onset PTLD post-BMT showed features similar to those in solid organ transplantation, in that the tumour was of recipient origin and responded well to the withdrawal of immuno-suppression. Of further interest is that recipient lymphoid regeneration had accompanied autologous haematopoietic regeneration and become a target for subsequent neoplastic transformation. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/bmt | en_HK |
dc.relation.ispartof | Bone Marrow Transplantation | en_HK |
dc.subject | Post-transplant lymphoproliferative disease | - |
dc.subject | Recipient origin | - |
dc.subject.mesh | Acute Disease | en_HK |
dc.subject.mesh | Adult | en_HK |
dc.subject.mesh | Bone Marrow Transplantation - adverse effects | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Graft vs Host Disease - mortality | en_HK |
dc.subject.mesh | Hematopoiesis - genetics | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Immunosuppression - adverse effects | en_HK |
dc.subject.mesh | Leukemia, Myeloid, Acute - genetics - therapy | en_HK |
dc.subject.mesh | Lymphoproliferative Disorders - genetics - immunology - pathology | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Recurrence | en_HK |
dc.subject.mesh | Remission Induction | en_HK |
dc.subject.mesh | Transplantation, Homologous | en_HK |
dc.title | Late onset post-transplantation lymphoproliferative disease of recipient origin following cytogenetic relapse and occult autologous haematopoietic regeneration after allogeneic bone marrow transplantation for acute myeloid leukaemia | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-3369&volume=28&issue=4&spage=417&epage=419&date=2001&atitle=Late+onset+post-transplantation+lymphoproliferative+disease+of+recipient+origin+following+cytogenetic+relapse+and+occult+autologous+haematopoietic+regeneration+after+allogeneic+bone+marrow+transplantation+for+acute+myeloid+leukaemia | en_HK |
dc.identifier.email | Liang, R:rliang@hku.hk | en_HK |
dc.identifier.email | Kwong, YL:ylkwong@hku.hk | en_HK |
dc.identifier.authority | Liang, R=rp00345 | en_HK |
dc.identifier.authority | Kwong, YL=rp00358 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1038/sj.bmt.1703144 | en_HK |
dc.identifier.pmid | 11571518 | en_HK |
dc.identifier.scopus | eid_2-s2.0-0034824213 | en_HK |
dc.identifier.hkuros | 67020 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0034824213&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 28 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 417 | en_HK |
dc.identifier.epage | 419 | en_HK |
dc.identifier.isi | WOS:000170808500018 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Au, WY=7202383089 | en_HK |
dc.identifier.scopusauthorid | Lie, AK=24284842400 | en_HK |
dc.identifier.scopusauthorid | Lee, CK=36087620900 | en_HK |
dc.identifier.scopusauthorid | Ma, SK=37020910400 | en_HK |
dc.identifier.scopusauthorid | Wan, TS=25623981600 | en_HK |
dc.identifier.scopusauthorid | Shek, TW=7005479861 | en_HK |
dc.identifier.scopusauthorid | Liang, R=26643224900 | en_HK |
dc.identifier.scopusauthorid | Kwong, YL=7102818954 | en_HK |
dc.identifier.issnl | 0268-3369 | - |