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Article: Pre-treatment with melatonin reduces volume of cerebral infarction in a permanent middle cerebral artery occlusion stroke model in the rat

TitlePre-treatment with melatonin reduces volume of cerebral infarction in a permanent middle cerebral artery occlusion stroke model in the rat
Authors
KeywordsAntioxidant
Focal cerebral ischemia
Free radicals
Melatonin
Neuroprotection
Triphenyltetrazolium chloride
Issue Date2002
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 2002, v. 318 n. 3, p. 141-144 How to Cite?
AbstractWe investigated whether pre-treatment with melatonin, a potent free radical scavenger and antioxidant, would protect against permanent focal cerebral ischemia without reperfusion in a rat middle cerebral artery occlusion (MCAO) model. A single dose of melatonin at 5, 15, or 50 mg/kg or the vehicle alone was given via an intraperitoneal injection at 0.5 h before permanent MCAO. Relative infarction volumes on day 3 were significantly reduced in the groups treated with melatonin at 5 (mean ± SEM, 17.0 ± 6.5%), 15 (18.1 ± 5.8%), or 50 (20.6 ± 5.0%) mg/kg when compared with the vehicle-treated group (37.1 ± 2.8%) and so melatonin treatment achieved a relative reduction in infarct volume by 54.2, 51.2 and 44.5%, respectively. Melatonin did not affect the hemodynamic parameters. Thus, pre-treatment with melatonin at a dose between 5 and 50 mg/kg protects against focal cerebral ischemia without reperfusion. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/77417
ISSN
2019 Impact Factor: 2.274
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPei, Zen_HK
dc.contributor.authorHo, HTSen_HK
dc.contributor.authorCheung, RTFen_HK
dc.date.accessioned2010-09-06T07:31:40Z-
dc.date.available2010-09-06T07:31:40Z-
dc.date.issued2002en_HK
dc.identifier.citationNeuroscience Letters, 2002, v. 318 n. 3, p. 141-144en_HK
dc.identifier.issn0304-3940en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77417-
dc.description.abstractWe investigated whether pre-treatment with melatonin, a potent free radical scavenger and antioxidant, would protect against permanent focal cerebral ischemia without reperfusion in a rat middle cerebral artery occlusion (MCAO) model. A single dose of melatonin at 5, 15, or 50 mg/kg or the vehicle alone was given via an intraperitoneal injection at 0.5 h before permanent MCAO. Relative infarction volumes on day 3 were significantly reduced in the groups treated with melatonin at 5 (mean ± SEM, 17.0 ± 6.5%), 15 (18.1 ± 5.8%), or 50 (20.6 ± 5.0%) mg/kg when compared with the vehicle-treated group (37.1 ± 2.8%) and so melatonin treatment achieved a relative reduction in infarct volume by 54.2, 51.2 and 44.5%, respectively. Melatonin did not affect the hemodynamic parameters. Thus, pre-treatment with melatonin at a dose between 5 and 50 mg/kg protects against focal cerebral ischemia without reperfusion. © 2002 Elsevier Science Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_HK
dc.relation.ispartofNeuroscience Lettersen_HK
dc.rightsNeuroscience Letters. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectAntioxidant-
dc.subjectFocal cerebral ischemia-
dc.subjectFree radicals-
dc.subjectMelatonin-
dc.subjectNeuroprotection-
dc.subjectTriphenyltetrazolium chloride-
dc.subject.meshAnimalsen_HK
dc.subject.meshBlood Pressure - drug effects - physiologyen_HK
dc.subject.meshBrain - drug effects - pathology - physiopathologyen_HK
dc.subject.meshCerebral Infarction - drug therapy - pathology - physiopathologyen_HK
dc.subject.meshCerebrovascular Circulation - drug effects - physiologyen_HK
dc.subject.meshDose-Response Relationship, Drugen_HK
dc.subject.meshDrug Administration Scheduleen_HK
dc.subject.meshFree Radical Scavengers - pharmacologyen_HK
dc.subject.meshHeart Rate - drug effects - physiologyen_HK
dc.subject.meshInfarction, Middle Cerebral Artery - drug therapy - pathology - physiopathologyen_HK
dc.subject.meshLaser-Doppler Flowmetryen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMelatonin - pharmacologyen_HK
dc.subject.meshNeuroprotective Agents - pharmacologyen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.titlePre-treatment with melatonin reduces volume of cerebral infarction in a permanent middle cerebral artery occlusion stroke model in the raten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3940&volume=318&spage=141&epage=144&date=2002&atitle=Pre-treatment+with+melatonin+reduces+volume+of+cerebral+infarction+in+a+permanent+middle+cerebral+artery+occlusion+stroke+model+in+the+raten_HK
dc.identifier.emailCheung, RTF:rtcheung@hku.hken_HK
dc.identifier.authorityCheung, RTF=rp00434en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0304-3940(01)02503-4en_HK
dc.identifier.pmid11803119-
dc.identifier.scopuseid_2-s2.0-0036468920en_HK
dc.identifier.hkuros87783en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036468920&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume318en_HK
dc.identifier.issue3en_HK
dc.identifier.spage141en_HK
dc.identifier.epage144en_HK
dc.identifier.isiWOS:000173643600008-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridPei, Z=23051646800en_HK
dc.identifier.scopusauthoridHo, HTS=15740869700en_HK
dc.identifier.scopusauthoridCheung, RTF=7202397498en_HK
dc.identifier.issnl0304-3940-

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