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Article: 2-[(3-Carboxy-1-oxoprogy1) amino]-2-deoxy-D-glucose induces apoptosis in Hep G2 cells

Title2-[(3-Carboxy-1-oxoprogy1) amino]-2-deoxy-D-glucose induces apoptosis in Hep G2 cells
Authors
Wu, JQi, DWei, KLi, JChen, XWang, ALiu, WXue, QQiao, L
Keywords2-[(3-carboxy-1-oxoprogy1)amino]-2-deoxy-D- glucose
Apoptosis
COPADG
Hep G2
Hepatoma
Issue Date2005
PublisherMorion LLC.
Citation
Experimental Oncology, 2005, v. 27 n. 1, p. 52-55 How to Cite?
AbstractAim: To determine the effect of 2-[(3-carboxy-1-oxoprogy1) amino]-2-deoxy-D-glucose (COPADG) on proliferation and apoptosis of human hepatocellular carcinoma cells (Hep G2). Methods: Hep G2 cells were cultured in RPMI-1640 medium in the presence of various concentrations of COPADG. Cell proliferation was determined by MTT assay. Apoptosis was determined by fluorescence microscopy, transmission electron microscopy, agarose gel electrophoresis of DNA fragmentation, and flow cytometry. Results: At the concentration ranging between 1-30 μM, COPADG potently inhibits growth and induce apoptosis of Hep G2 cells. Conclusions: COPADG could effectively induce apoptosis in Hep G2 cells. It may be potentially useful as a new agent for treatment of human hepatocellular carcinoma.
Persistent Identifierhttp://hdl.handle.net/10722/77327
ISSN
0204-3564
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorWu, Jen_HK
dc.contributor.authorQi, Den_HK
dc.contributor.authorWei, Ken_HK
dc.contributor.authorLi, Jen_HK
dc.contributor.authorChen, Xen_HK
dc.contributor.authorWang, Aen_HK
dc.contributor.authorLiu, Wen_HK
dc.contributor.authorXue, Qen_HK
dc.contributor.authorQiao, Len_HK
dc.date.accessioned2010-09-06T07:30:43Z-
dc.date.available2010-09-06T07:30:43Z-
dc.date.issued2005en_HK
dc.identifier.citationExperimental Oncology, 2005, v. 27 n. 1, p. 52-55en_HK
dc.identifier.issn0204-3564en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77327-
dc.description.abstractAim: To determine the effect of 2-[(3-carboxy-1-oxoprogy1) amino]-2-deoxy-D-glucose (COPADG) on proliferation and apoptosis of human hepatocellular carcinoma cells (Hep G2). Methods: Hep G2 cells were cultured in RPMI-1640 medium in the presence of various concentrations of COPADG. Cell proliferation was determined by MTT assay. Apoptosis was determined by fluorescence microscopy, transmission electron microscopy, agarose gel electrophoresis of DNA fragmentation, and flow cytometry. Results: At the concentration ranging between 1-30 μM, COPADG potently inhibits growth and induce apoptosis of Hep G2 cells. Conclusions: COPADG could effectively induce apoptosis in Hep G2 cells. It may be potentially useful as a new agent for treatment of human hepatocellular carcinoma.en_HK
dc.languageengen_HK
dc.publisherMorion LLC.en_HK
dc.relation.ispartofExperimental Oncologyen_HK
dc.subject2-[(3-carboxy-1-oxoprogy1)amino]-2-deoxy-D- glucoseen_HK
dc.subjectApoptosisen_HK
dc.subjectCOPADGen_HK
dc.subjectHep G2en_HK
dc.subjectHepatomaen_HK
dc.title2-[(3-Carboxy-1-oxoprogy1) amino]-2-deoxy-D-glucose induces apoptosis in Hep G2 cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1812-9269&volume=27&spage=52&epage=55&date=2005&atitle=2-[(3-carboxy-1-oxoprogy1)+amino]-2-deoxy-D-glucose+induces+apoptosis+in+Hep+G2+cells.en_HK
dc.identifier.emailQiao, L: lq8688@hotmail.comen_HK
dc.identifier.authorityQiao, L=rp00513en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid15812358-
dc.identifier.scopuseid_2-s2.0-17444369361en_HK
dc.identifier.hkuros132400en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17444369361&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue1en_HK
dc.identifier.spage52en_HK
dc.identifier.epage55en_HK
dc.identifier.scopusauthoridWu, J=7409254006en_HK
dc.identifier.scopusauthoridQi, D=8356996200en_HK
dc.identifier.scopusauthoridWei, K=8356996300en_HK
dc.identifier.scopusauthoridLi, J=26643574400en_HK
dc.identifier.scopusauthoridChen, X=35147703300en_HK
dc.identifier.scopusauthoridWang, A=7404619798en_HK
dc.identifier.scopusauthoridLiu, W=26423103100en_HK
dc.identifier.scopusauthoridXue, Q=36071456600en_HK
dc.identifier.scopusauthoridQiao, L=7202151719en_HK
dc.identifier.issnl0204-3564-

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