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Article: Chromosomal abnormalities in T-cell large granular lymphocyte leukaemia: Report of two cases and review of the literature

TitleChromosomal abnormalities in T-cell large granular lymphocyte leukaemia: Report of two cases and review of the literature
Authors
Wong, KFChan, JCWLiu, HSYMan, CKwong, YL
KeywordsCytogenetics
del(3)
inv(14)
inv(7)
T-cell large granular lymphocyte leukaemia
Issue Date2002
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 2002, v. 116 n. 3, p. 598-600 How to Cite?
DOI: http://dx.doi.org/10.1046/j.0007-1048.2001.03315.x
AbstractCytogenetic information on T-cell large granular lymphocyte leukaemia (T-LGL; large granular lymphocytosis) is limited. We report two cases of T-LGL with unusual karyotypic aberrations. The first case showed a novel inv(7)(p15q22) as the sole chromosomal abnormality, while the second case showed an inv(14)(q11q32) with evidence of clonal evolution. The breakpoints 7p14-p15 and 14q11 coincide with the T-cell receptor (TCR)-γ and TCR-α/TCR-δ gene loci respectively. This is the first report describing the possible involvement of T-cell receptor genes in karyotypic aberrations in T-LGL.
Persistent Identifierhttp://hdl.handle.net/10722/77275
ISSN
0007-1048
2021 Impact Factor: 8.615
2020 SCImago Journal Rankings: 1.907
ISI Accession Number ID
WOS:000174217500015
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorWong, KFen_HK
dc.contributor.authorChan, JCWen_HK
dc.contributor.authorLiu, HSYen_HK
dc.contributor.authorMan, Cen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:30:08Z-
dc.date.available2010-09-06T07:30:08Z-
dc.date.issued2002en_HK
dc.identifier.citationBritish Journal Of Haematology, 2002, v. 116 n. 3, p. 598-600en_HK
dc.identifier.issn0007-1048en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77275-
dc.description.abstractCytogenetic information on T-cell large granular lymphocyte leukaemia (T-LGL; large granular lymphocytosis) is limited. We report two cases of T-LGL with unusual karyotypic aberrations. The first case showed a novel inv(7)(p15q22) as the sole chromosomal abnormality, while the second case showed an inv(14)(q11q32) with evidence of clonal evolution. The breakpoints 7p14-p15 and 14q11 coincide with the T-cell receptor (TCR)-γ and TCR-α/TCR-δ gene loci respectively. This is the first report describing the possible involvement of T-cell receptor genes in karyotypic aberrations in T-LGL.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_HK
dc.relation.ispartofBritish Journal of Haematologyen_HK
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectCytogenetics-
dc.subjectdel(3)-
dc.subjectinv(14)-
dc.subjectinv(7)-
dc.subjectT-cell large granular lymphocyte leukaemia-
dc.subject.meshAdulten_HK
dc.subject.meshChromosome Aberrationsen_HK
dc.subject.meshChromosomes, Human, Pair 14 - geneticsen_HK
dc.subject.meshChromosomes, Human, Pair 7 - geneticsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKaryotypingen_HK
dc.subject.meshLeukemia, T-Cell - geneticsen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshReceptors, Antigen, T-Cell, alpha-beta - geneticsen_HK
dc.subject.meshReceptors, Antigen, T-Cell, gamma-delta - geneticsen_HK
dc.titleChromosomal abnormalities in T-cell large granular lymphocyte leukaemia: Report of two cases and review of the literatureen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1048&volume=116&issue=3&spage=598&epage=600&date=2002&atitle=Chromosomal+abnormalities+in+T-cell+large+granular+lymphocyte+leukaemia:+report+of+two+cases+and+review+of+the+literatureen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1046/j.0007-1048.2001.03315.xen_HK
dc.identifier.pmid11849217-
dc.identifier.scopuseid_2-s2.0-0036183281en_HK
dc.identifier.hkuros108951en_HK
dc.identifier.hkuros67809-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036183281&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume116en_HK
dc.identifier.issue3en_HK
dc.identifier.spage598en_HK
dc.identifier.epage600en_HK
dc.identifier.isiWOS:000174217500015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, KF=7404759860en_HK
dc.identifier.scopusauthoridChan, JCW=9940606800en_HK
dc.identifier.scopusauthoridLiu, HSY=8501559700en_HK
dc.identifier.scopusauthoridMan, C=7005722377en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.issnl0007-1048-

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