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Article: Fabrication and characterization of composite microspheres containing carbonated hydroxyapatite nanoparticles
Title | Fabrication and characterization of composite microspheres containing carbonated hydroxyapatite nanoparticles |
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Authors | |
Keywords | Bone tissue engineering Carbonated hydroxyapatite Composite microsphere Nanoparticle Poly(L-lactide) |
Issue Date | 2007 |
Publisher | Trans Tech Publications Ltd. The Journal's web site is located at http://www.scientific.net |
Citation | Key Engineering Materials, 2007, v. 334-335 II, p. 1221-1224 How to Cite? |
Abstract | Nano-sized carbonated hydroxyapatite (CHAp) particles were firstly synthesized using a nanoemulsion method. TEM analyses revealed that as-synthesized nanoparticles were calcium-deficient and spherical in shape (diameter: 16.8±2.6nm). Biocomposite microspheres comprising CHAp nanoparticles and poly(L-lactide) (PLLA) were fabricated using the single emulsion solvent evaporation technique. SEM images showed that composite microspheres were mainly 5-30 μm in size despite the change of CHAp nanoparticle content. When the CHAp nanoparticle content in composite microspheres was below 10 wt%, all nanoparticles were encapsulated within the microspheres which possessed a nanocomposite structure. DSC results showed that the crystallinity of the PLLA matrix of microspheres increased from 38 to 42% when the CHAp nanoparticle content was increased from 0 to 20 wt%. The biocomposite microspheres should be a suitable material for constructing bone tissue engineering scaffolds. |
Persistent Identifier | http://hdl.handle.net/10722/76212 |
ISSN | 2023 SCImago Journal Rankings: 0.172 |
References |
DC Field | Value | Language |
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dc.contributor.author | Zhou, WY | en_HK |
dc.contributor.author | Wang, M | en_HK |
dc.contributor.author | Cheung, WL | en_HK |
dc.date.accessioned | 2010-09-06T07:18:43Z | - |
dc.date.available | 2010-09-06T07:18:43Z | - |
dc.date.issued | 2007 | en_HK |
dc.identifier.citation | Key Engineering Materials, 2007, v. 334-335 II, p. 1221-1224 | en_HK |
dc.identifier.issn | 1013-9826 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/76212 | - |
dc.description.abstract | Nano-sized carbonated hydroxyapatite (CHAp) particles were firstly synthesized using a nanoemulsion method. TEM analyses revealed that as-synthesized nanoparticles were calcium-deficient and spherical in shape (diameter: 16.8±2.6nm). Biocomposite microspheres comprising CHAp nanoparticles and poly(L-lactide) (PLLA) were fabricated using the single emulsion solvent evaporation technique. SEM images showed that composite microspheres were mainly 5-30 μm in size despite the change of CHAp nanoparticle content. When the CHAp nanoparticle content in composite microspheres was below 10 wt%, all nanoparticles were encapsulated within the microspheres which possessed a nanocomposite structure. DSC results showed that the crystallinity of the PLLA matrix of microspheres increased from 38 to 42% when the CHAp nanoparticle content was increased from 0 to 20 wt%. The biocomposite microspheres should be a suitable material for constructing bone tissue engineering scaffolds. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Trans Tech Publications Ltd. The Journal's web site is located at http://www.scientific.net | en_HK |
dc.relation.ispartof | Key Engineering Materials | en_HK |
dc.rights | Key Engineering Materials. Copyright © Trans Tech Publications Ltd. | en_HK |
dc.subject | Bone tissue engineering | en_HK |
dc.subject | Carbonated hydroxyapatite | en_HK |
dc.subject | Composite microsphere | en_HK |
dc.subject | Nanoparticle | en_HK |
dc.subject | Poly(L-lactide) | en_HK |
dc.title | Fabrication and characterization of composite microspheres containing carbonated hydroxyapatite nanoparticles | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1013-9826&volume=334-335&spage=1221&epage=1224&date=2007&atitle=Fabrication+and+characterization+of+composite+microspheres+containing+carbonated+hydroxyapatite+nanoparticles | en_HK |
dc.identifier.email | Zhou, WY:wzhou@business.hku.hk | en_HK |
dc.identifier.email | Wang, M:memwang@hku.hk | en_HK |
dc.identifier.email | Cheung, WL:wlcheung@hkucc.hku.hk | en_HK |
dc.identifier.authority | Zhou, WY=rp01128 | en_HK |
dc.identifier.authority | Wang, M=rp00185 | en_HK |
dc.identifier.authority | Cheung, WL=rp00103 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.scopus | eid_2-s2.0-33847020448 | en_HK |
dc.identifier.hkuros | 132263 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33847020448&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 334-335 II | en_HK |
dc.identifier.spage | 1221 | en_HK |
dc.identifier.epage | 1224 | en_HK |
dc.publisher.place | Switzerland | en_HK |
dc.identifier.scopusauthorid | Zhou, WY=10739745800 | en_HK |
dc.identifier.scopusauthorid | Wang, M=15749714100 | en_HK |
dc.identifier.scopusauthorid | Cheung, WL=7202743084 | en_HK |
dc.identifier.issnl | 1013-9826 | - |