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Article: White matter volume and anisotropy in preterm children: A pilot study of neurocognitive correlates

TitleWhite matter volume and anisotropy in preterm children: A pilot study of neurocognitive correlates
Authors
Issue Date2007
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.pedresearch.org/
Citation
Pediatric Research, 2007, v. 61 n. 6, p. 732-736 How to Cite?
AbstractThe objectives of this study were to evaluate the differences in whole brain white matter (WM) volume and anisotropy between preterm and term children and to determine the relationships with cognitive outcome. Twenty-five low birth weight (BW), preterm, neurologically normal children between 8.8 and 11.5 y of age were recruited for volumetric and diffusion-tensor magnetic resonance imaging (DTI), together with 13 age-matched term control subjects. Subsequent intelligence quotient (IQ) testing was performed for 21 preterm children within 6 mo of imaging studies. We computed the mean volume and fractional anisotropy (FA) of the whole brain WM and compared the differences between the two groups. Mean WM volume and FA were significantly lower in the preterm group (p = 0.014 and p < 0.001, respectively). Multiple regression analysis found both WM volume and FA to be independent variables significantly affecting full scale IQ (FSIQ) (r = 0.407, p = 0.021 and r = 0.496, p = 0.005, respectively) after adjusting for BW, gestational age (GA), and gender. In the evaluation of the whole brain WM of preterm children, we found that both volume and FA remain reduced at late childhood with both parameters significantly affecting long-term cognitive outcome. © International Pediatrics Research Foundation, Inc. 2007. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/72401
ISSN
2023 Impact Factor: 3.1
2023 SCImago Journal Rankings: 1.184
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYung, Aen_HK
dc.contributor.authorPoon, Gen_HK
dc.contributor.authorQiu, DQen_HK
dc.contributor.authorChu, Jen_HK
dc.contributor.authorLam, Ben_HK
dc.contributor.authorLeung, Cen_HK
dc.contributor.authorGoh, Wen_HK
dc.contributor.authorKhong, PLen_HK
dc.date.accessioned2010-09-06T06:41:21Z-
dc.date.available2010-09-06T06:41:21Z-
dc.date.issued2007en_HK
dc.identifier.citationPediatric Research, 2007, v. 61 n. 6, p. 732-736en_HK
dc.identifier.issn0031-3998en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72401-
dc.description.abstractThe objectives of this study were to evaluate the differences in whole brain white matter (WM) volume and anisotropy between preterm and term children and to determine the relationships with cognitive outcome. Twenty-five low birth weight (BW), preterm, neurologically normal children between 8.8 and 11.5 y of age were recruited for volumetric and diffusion-tensor magnetic resonance imaging (DTI), together with 13 age-matched term control subjects. Subsequent intelligence quotient (IQ) testing was performed for 21 preterm children within 6 mo of imaging studies. We computed the mean volume and fractional anisotropy (FA) of the whole brain WM and compared the differences between the two groups. Mean WM volume and FA were significantly lower in the preterm group (p = 0.014 and p < 0.001, respectively). Multiple regression analysis found both WM volume and FA to be independent variables significantly affecting full scale IQ (FSIQ) (r = 0.407, p = 0.021 and r = 0.496, p = 0.005, respectively) after adjusting for BW, gestational age (GA), and gender. In the evaluation of the whole brain WM of preterm children, we found that both volume and FA remain reduced at late childhood with both parameters significantly affecting long-term cognitive outcome. © International Pediatrics Research Foundation, Inc. 2007. All Rights Reserved.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.pedresearch.org/en_HK
dc.relation.ispartofPediatric Researchen_HK
dc.rightsPediatric Research. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subject.meshBirth Weighten_HK
dc.subject.meshBrain - anatomy & histologyen_HK
dc.subject.meshChilden_HK
dc.subject.meshCognitionen_HK
dc.subject.meshDiffusion Magnetic Resonance Imagingen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfant, Newbornen_HK
dc.subject.meshInfant, Premature - physiologyen_HK
dc.subject.meshInfant, Very Low Birth Weight - physiologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshPilot Projectsen_HK
dc.titleWhite matter volume and anisotropy in preterm children: A pilot study of neurocognitive correlatesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0031-3998&volume=61&spage=732&epage=736&date=2007&atitle=White+matter+volume+and+anisotropy+in+preterm+children:+a+pilot+study+of+neurocognitive+correlatesen_HK
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1203/pdr.0b013e31805365dben_HK
dc.identifier.pmid17426647-
dc.identifier.scopuseid_2-s2.0-34249058942en_HK
dc.identifier.hkuros128334en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34249058942&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume61en_HK
dc.identifier.issue6en_HK
dc.identifier.spage732en_HK
dc.identifier.epage736en_HK
dc.identifier.isiWOS:000246787300020-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYung, A=36922523200en_HK
dc.identifier.scopusauthoridPoon, G=8083313700en_HK
dc.identifier.scopusauthoridQiu, DQ=12778150600en_HK
dc.identifier.scopusauthoridChu, J=16314814100en_HK
dc.identifier.scopusauthoridLam, B=8553938300en_HK
dc.identifier.scopusauthoridLeung, C=8206219600en_HK
dc.identifier.scopusauthoridGoh, W=7005651404en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.issnl0031-3998-

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