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Article: Treatment outcome after radiotherapy alone for patients with Stage I-II nasopharyngeal carcinoma
Title | Treatment outcome after radiotherapy alone for patients with Stage I-II nasopharyngeal carcinoma |
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Authors | |
Keywords | American Joint Committee on Cancer (AJCC) Early stage Nasopharyngeal carcinoma (NPC) Prognosis Radiotherapy Tumor stage |
Issue Date | 2003 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741 |
Citation | Cancer, 2003, v. 98 n. 1, p. 74-80 How to Cite? |
Abstract | BACKGROUND. The objective of this study was to review the long-term treatment outcome of patients with American Joint Committee on Cancer (AJCC) 1997 Stage I-II nasopharyngeal carcinoma (NPC) who were treated with radiotherapy alone. METHODS. One hundred forty-one patients with NPC had AJCC 1997 Stage I-II disease (Stage I NPC, 50 patients; Stage II NPC, 91 patients) after restaging and were treated with radiotherapy alone between September 1989 and August 1991. Fifty-seven patients had lymph node disease, and the median greatest lymph node dimension was 3 cm. The median dose to the nasopharynx was 65 grays. The median follow-up was 82 months (range, 4-141 months). RESULTS. Patients who had Stage I disease had an excellent outcome after radiotherapy. The 10-year disease specific survival, recurrence free survival (RFS), local RFS, lymph node RFS, and distant metastasis free survival rates were 98%, 94%, 96%, 98%, and 98%, respectively. Patients who had Stage II disease had a worse outcome compared with patients who had Stage I disease: The corresponding 10-year survival rates were 60%, 51%, 78%, 93%, and 64%. The differences all were significant except for lymph node control. Among patients who had Stage II disease, those with T1-T2N1 NPC appeared to have a worse outcome compared with patients who had T2N0 NPC. No significant differences in survival rates were found with respect to lymph node size or status for patients with T1-T2N1 disease. CONCLUSIONS. When patients with NPC had their disease staged according to the AJCC 1997 classification system, patients with Stage I disease had an excellent outcome after they were treated with radiotherapy alone. Patients with Stage II disease, especially those with T1-T2N1 disease, had a relatively worse outcome, and more aggressive therapy, such as combined-modality treatment, may be indicated for those patients. © 2003 American Cancer Society. |
Persistent Identifier | http://hdl.handle.net/10722/72009 |
ISSN | 2023 Impact Factor: 6.1 2023 SCImago Journal Rankings: 2.887 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Chua, DTT | en_HK |
dc.contributor.author | Sham, JST | en_HK |
dc.contributor.author | Kwong, DLW | en_HK |
dc.contributor.author | Au, GKH | en_HK |
dc.date.accessioned | 2010-09-06T06:37:26Z | - |
dc.date.available | 2010-09-06T06:37:26Z | - |
dc.date.issued | 2003 | en_HK |
dc.identifier.citation | Cancer, 2003, v. 98 n. 1, p. 74-80 | en_HK |
dc.identifier.issn | 0008-543X | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/72009 | - |
dc.description.abstract | BACKGROUND. The objective of this study was to review the long-term treatment outcome of patients with American Joint Committee on Cancer (AJCC) 1997 Stage I-II nasopharyngeal carcinoma (NPC) who were treated with radiotherapy alone. METHODS. One hundred forty-one patients with NPC had AJCC 1997 Stage I-II disease (Stage I NPC, 50 patients; Stage II NPC, 91 patients) after restaging and were treated with radiotherapy alone between September 1989 and August 1991. Fifty-seven patients had lymph node disease, and the median greatest lymph node dimension was 3 cm. The median dose to the nasopharynx was 65 grays. The median follow-up was 82 months (range, 4-141 months). RESULTS. Patients who had Stage I disease had an excellent outcome after radiotherapy. The 10-year disease specific survival, recurrence free survival (RFS), local RFS, lymph node RFS, and distant metastasis free survival rates were 98%, 94%, 96%, 98%, and 98%, respectively. Patients who had Stage II disease had a worse outcome compared with patients who had Stage I disease: The corresponding 10-year survival rates were 60%, 51%, 78%, 93%, and 64%. The differences all were significant except for lymph node control. Among patients who had Stage II disease, those with T1-T2N1 NPC appeared to have a worse outcome compared with patients who had T2N0 NPC. No significant differences in survival rates were found with respect to lymph node size or status for patients with T1-T2N1 disease. CONCLUSIONS. When patients with NPC had their disease staged according to the AJCC 1997 classification system, patients with Stage I disease had an excellent outcome after they were treated with radiotherapy alone. Patients with Stage II disease, especially those with T1-T2N1 disease, had a relatively worse outcome, and more aggressive therapy, such as combined-modality treatment, may be indicated for those patients. © 2003 American Cancer Society. | en_HK |
dc.language | eng | en_HK |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741 | en_HK |
dc.relation.ispartof | Cancer | en_HK |
dc.rights | Cancer. Copyright © John Wiley & Sons, Inc. | en_HK |
dc.subject | American Joint Committee on Cancer (AJCC) | en_HK |
dc.subject | Early stage | en_HK |
dc.subject | Nasopharyngeal carcinoma (NPC) | en_HK |
dc.subject | Prognosis | en_HK |
dc.subject | Radiotherapy | en_HK |
dc.subject | Tumor stage | en_HK |
dc.subject.mesh | Adult | en_HK |
dc.subject.mesh | Aged | en_HK |
dc.subject.mesh | Aged, 80 and over | en_HK |
dc.subject.mesh | Disease-Free Survival | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Middle Aged | en_HK |
dc.subject.mesh | Nasopharyngeal Neoplasms - mortality - pathology - radiotherapy | en_HK |
dc.subject.mesh | Neoplasm Metastasis | en_HK |
dc.subject.mesh | Neoplasm Staging | en_HK |
dc.subject.mesh | Radiation Dosage | en_HK |
dc.subject.mesh | Retrospective Studies | en_HK |
dc.subject.mesh | Treatment Outcome | en_HK |
dc.title | Treatment outcome after radiotherapy alone for patients with Stage I-II nasopharyngeal carcinoma | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-543X&volume=98&spage=74&epage=80&date=2003&atitle=Treatment+Outcome+After+Radiotherapy+Alone+For+Patients+With+Stage+I-II+Nasopharyngeal+Carcinoma | en_HK |
dc.identifier.email | Chua, DTT: dttchua@hkucc.hku.hk | en_HK |
dc.identifier.email | Kwong, DLW: dlwkwong@hku.hk | en_HK |
dc.identifier.authority | Chua, DTT=rp00415 | en_HK |
dc.identifier.authority | Kwong, DLW=rp00414 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/cncr.11485 | en_HK |
dc.identifier.pmid | 12833458 | - |
dc.identifier.scopus | eid_2-s2.0-0037664988 | en_HK |
dc.identifier.hkuros | 82043 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0037664988&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 98 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 74 | en_HK |
dc.identifier.epage | 80 | en_HK |
dc.identifier.isi | WOS:000183671100011 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Chua, DTT=7006773480 | en_HK |
dc.identifier.scopusauthorid | Sham, JST=7101655565 | en_HK |
dc.identifier.scopusauthorid | Kwong, DLW=15744231600 | en_HK |
dc.identifier.scopusauthorid | Au, GKH=7003748615 | en_HK |
dc.identifier.issnl | 0008-543X | - |