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- Publisher Website: 10.1034/j.1600-0714.2000.290404.x
- Scopus: eid_2-s2.0-0034024114
- PMID: 10766394
- WOS: WOS:000086558400004
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Article: Cyclin D1 expression in oral squamous cell carcinomas: Clinicopathological relevance and correlation with p53 expression
Title | Cyclin D1 expression in oral squamous cell carcinomas: Clinicopathological relevance and correlation with p53 expression |
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Authors | |
Keywords | Cyclin D1 Oral p53 Squamous cell carcinoma |
Issue Date | 2000 |
Publisher | Blackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JOPM |
Citation | Journal Of Oral Pathology And Medicine, 2000, v. 29 n. 4, p. 167-172 How to Cite? |
Abstract | The aim of the present study is to study the relationship between cyclin D1 and the clinicopathological features of oral squamous cell carcinomas. The cyclin D1 and p53 expression in oral squamous cell carcinomas from 56 patients (45 men, 11 women) was studied by immunohistochemistry using monoclonal antibodies. The correlation between cyclin D1 and the clinicopathological features of the oral cancers was evaluated. Cyclin D1 expression was found in 63% of oral squamous cell carcinomas; it was often weak but was more frequently positive in high-grade lesions (P=0.019). The expression was positively correlated with p53 expression (P=0.06). Radiation therapy did not alter the expression of either cyclin D1 or p53 proteins. Expression of these proteins was not related to the age, gender or survival of the patients, or to stages of the tumors. The cyclin D1 expression was more frequently seen in patients with squamous cell carcinomas of oropharynx, palate, floor of mouth and gingiva. To conclude, cyclin D1 was frequently expressed in oral squamous cell carcinomas. This expression was related to the grade of the tumors and was not similar in various regions in the oral cavity, which may indicate the different tumor biology of cancers from these regions. |
Persistent Identifier | http://hdl.handle.net/10722/72000 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.716 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lam, KY | en_HK |
dc.contributor.author | Ng, IOL | en_HK |
dc.contributor.author | Yuen, APW | en_HK |
dc.contributor.author | Kwong, DLW | en_HK |
dc.contributor.author | Wei, W | en_HK |
dc.date.accessioned | 2010-09-06T06:37:21Z | - |
dc.date.available | 2010-09-06T06:37:21Z | - |
dc.date.issued | 2000 | en_HK |
dc.identifier.citation | Journal Of Oral Pathology And Medicine, 2000, v. 29 n. 4, p. 167-172 | en_HK |
dc.identifier.issn | 0904-2512 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/72000 | - |
dc.description.abstract | The aim of the present study is to study the relationship between cyclin D1 and the clinicopathological features of oral squamous cell carcinomas. The cyclin D1 and p53 expression in oral squamous cell carcinomas from 56 patients (45 men, 11 women) was studied by immunohistochemistry using monoclonal antibodies. The correlation between cyclin D1 and the clinicopathological features of the oral cancers was evaluated. Cyclin D1 expression was found in 63% of oral squamous cell carcinomas; it was often weak but was more frequently positive in high-grade lesions (P=0.019). The expression was positively correlated with p53 expression (P=0.06). Radiation therapy did not alter the expression of either cyclin D1 or p53 proteins. Expression of these proteins was not related to the age, gender or survival of the patients, or to stages of the tumors. The cyclin D1 expression was more frequently seen in patients with squamous cell carcinomas of oropharynx, palate, floor of mouth and gingiva. To conclude, cyclin D1 was frequently expressed in oral squamous cell carcinomas. This expression was related to the grade of the tumors and was not similar in various regions in the oral cavity, which may indicate the different tumor biology of cancers from these regions. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Blackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JOPM | en_HK |
dc.relation.ispartof | Journal of Oral Pathology and Medicine | en_HK |
dc.subject | Cyclin D1 | en_HK |
dc.subject | Oral | en_HK |
dc.subject | p53 | en_HK |
dc.subject | Squamous cell carcinoma | en_HK |
dc.subject.mesh | Adult | en_HK |
dc.subject.mesh | Age Factors | en_HK |
dc.subject.mesh | Aged | en_HK |
dc.subject.mesh | Aged, 80 and over | en_HK |
dc.subject.mesh | Antibodies, Monoclonal - diagnostic use | en_HK |
dc.subject.mesh | Carcinoma, Squamous Cell - genetics - pathology - radiotherapy | en_HK |
dc.subject.mesh | Chi-Square Distribution | en_HK |
dc.subject.mesh | Cyclin D1 - genetics | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Gene Expression Regulation, Neoplastic | en_HK |
dc.subject.mesh | Gingival Neoplasms - genetics - pathology | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Immunohistochemistry | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Middle Aged | en_HK |
dc.subject.mesh | Mouth Floor - pathology | en_HK |
dc.subject.mesh | Mouth Neoplasms - genetics - pathology - radiotherapy | en_HK |
dc.subject.mesh | Neoplasm Staging | en_HK |
dc.subject.mesh | Oropharyngeal Neoplasms - genetics - pathology | en_HK |
dc.subject.mesh | Palatal Neoplasms - genetics - pathology | en_HK |
dc.subject.mesh | Sex Factors | en_HK |
dc.subject.mesh | Survival Rate | en_HK |
dc.subject.mesh | Tumor Suppressor Protein p53 - genetics | en_HK |
dc.title | Cyclin D1 expression in oral squamous cell carcinomas: Clinicopathological relevance and correlation with p53 expression | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0278-2391&volume=29&spage=167&epage=172&date=2000&atitle=Cyclin+D1+expression+in+oral+squamous+cell+carcinomas:+clinicopathological+relevance+and+correlation+with+p53+expression | en_HK |
dc.identifier.email | Ng, IOL: iolng@hkucc.hku.hk | en_HK |
dc.identifier.email | Kwong, DLW: dlwkwong@hku.hk | en_HK |
dc.identifier.email | Wei, W: hrmswwi@hku.hk | en_HK |
dc.identifier.authority | Ng, IOL=rp00335 | en_HK |
dc.identifier.authority | Kwong, DLW=rp00414 | en_HK |
dc.identifier.authority | Wei, W=rp00323 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1034/j.1600-0714.2000.290404.x | en_HK |
dc.identifier.pmid | 10766394 | - |
dc.identifier.scopus | eid_2-s2.0-0034024114 | en_HK |
dc.identifier.hkuros | 50595 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0034024114&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 29 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 167 | en_HK |
dc.identifier.epage | 172 | en_HK |
dc.identifier.isi | WOS:000086558400004 | - |
dc.publisher.place | Denmark | en_HK |
dc.identifier.scopusauthorid | Lam, KY=7403657165 | en_HK |
dc.identifier.scopusauthorid | Ng, IOL=7102753722 | en_HK |
dc.identifier.scopusauthorid | Yuen, APW=7006290111 | en_HK |
dc.identifier.scopusauthorid | Kwong, DLW=15744231600 | en_HK |
dc.identifier.scopusauthorid | Wei, W=7403321552 | en_HK |
dc.identifier.issnl | 0904-2512 | - |