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Article: A small synthetic molecule forms chloride channels to mediate chloride transport across cell membranes

TitleA small synthetic molecule forms chloride channels to mediate chloride transport across cell membranes
Authors
Li, XShen, BYao, XQYang, D
KeywordsCell Membrane
Chloride Channels
Ion Transport
Models, Biological
Nitrates
Issue Date2007
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html
Citation
Journal Of The American Chemical Society, 2007, v. 129 n. 23, p. 7264-7265 How to Cite?
DOI: http://dx.doi.org/10.1021/ja071961h
AbstractSynthetic ion channels that mimic the functions of natural ion channels are of great interest in chemistry, biochemistry, biology, and materials science. In this paper, we present a novel small synthetic molecule that self-assembles to form chloride channels in lipid bilayers. This compound is the smallest molecule known to form potent synthetic chloride ion channels. It can also partition into plasma membranes of living cells and therein increase anion permeability. This compound has the potential to become a novel lead compound for the treatment of human diseases associated with Cl- channel dysfunctions. Copyright © 2007 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/69593
ISSN
0002-7863
2021 Impact Factor: 16.383
2020 SCImago Journal Rankings: 7.115
ISI Accession Number ID
WOS:000247072300029
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLi, Xen_HK
dc.contributor.authorShen, Ben_HK
dc.contributor.authorYao, XQen_HK
dc.contributor.authorYang, Den_HK
dc.date.accessioned2010-09-06T06:15:05Z-
dc.date.available2010-09-06T06:15:05Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of The American Chemical Society, 2007, v. 129 n. 23, p. 7264-7265en_HK
dc.identifier.issn0002-7863en_HK
dc.identifier.urihttp://hdl.handle.net/10722/69593-
dc.description.abstractSynthetic ion channels that mimic the functions of natural ion channels are of great interest in chemistry, biochemistry, biology, and materials science. In this paper, we present a novel small synthetic molecule that self-assembles to form chloride channels in lipid bilayers. This compound is the smallest molecule known to form potent synthetic chloride ion channels. It can also partition into plasma membranes of living cells and therein increase anion permeability. This compound has the potential to become a novel lead compound for the treatment of human diseases associated with Cl- channel dysfunctions. Copyright © 2007 American Chemical Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.htmlen_HK
dc.relation.ispartofJournal of the American Chemical Societyen_HK
dc.subjectCell Membrane-
dc.subjectChloride Channels-
dc.subjectIon Transport-
dc.subjectModels, Biological-
dc.subjectNitrates-
dc.titleA small synthetic molecule forms chloride channels to mediate chloride transport across cell membranesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-7863&volume=129&spage=7264&epage=7265&date=2007&atitle=A+Small+Synthetic+Molecule+Forms+Chloride+Channels+to+Mediate+Chloride+Transport+across+Cell+Membranes+en_HK
dc.identifier.emailYang, D:yangdan@hku.hken_HK
dc.identifier.authorityYang, D=rp00825en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/ja071961hen_HK
dc.identifier.pmid17503826-
dc.identifier.scopuseid_2-s2.0-34250837547en_HK
dc.identifier.hkuros135036en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34250837547&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume129en_HK
dc.identifier.issue23en_HK
dc.identifier.spage7264en_HK
dc.identifier.epage7265en_HK
dc.identifier.eissn1520-5126-
dc.identifier.isiWOS:000247072300029-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, X=36072382700en_HK
dc.identifier.scopusauthoridShen, B=8958686600en_HK
dc.identifier.scopusauthoridYao, XQ=7402529434en_HK
dc.identifier.scopusauthoridYang, D=7404800756en_HK
dc.identifier.issnl0002-7863-

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