Artificial Cold Exposure Induced Stroke in Renovascular Hypertensive Rats and its Association with Cold-inducible RNA Binding Protein mRNA Expression in Brain Tissue and Blood Pressure

Abstract

Chemical inducers of differentiation, such as dimethylsulfoxide, N-methylacetamide and sodium butyrate, induce various kinds of differentiated characteristics in tumor cell lines as shown by numerous studies. In this study we showed that one common property of this group of chemicals is their ability to induce β-adrenergic response of adenylate cyclase in cell cultures, including Friend erythroleukemic cells, HeLa cells and rat fetal hepatocytes. This induction appears to be an early event in the differentiation, since it precedes the appearance of other differentiated characteristics, such as hemoglobin synthesis in erythroleukemic cells. This induced hormone response may contribute to the regulation of subsequent steps of differentiation.