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Article: Ultrastructural study of mineralization of a strontium-containing hydroxyapatite (Sr-HA) cement in vivo.

TitleUltrastructural study of mineralization of a strontium-containing hydroxyapatite (Sr-HA) cement in vivo.
Authors
Wong, CTChen, QZLu, WWLeong, JCChan, WKCheung, KMLuk, KD
Issue Date2004
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304/
Citation
Journal Of Biomedical Materials Research. Part A, 2004, v. 70 A n. 3, p. 428-435 How to Cite?
DOI: http://dx.doi.org/10.1002/jbm.a.30097
AbstractThe purpose of this study was to investigate the mineralization leading to osseointegration of strontium-containing hydroxyapatite (Sr-HA) bioactive bone cement injected into cancellous bone in vivo. Sr-HA cement was injected into the ilium of rabbits for 1, 3, and 6 months. The bone mineralization area was found to be largest at 3 months, then at 1 month, and smallest at 6 months (p < 0.01) measured with tetracycline labeling. Osseointegration of Sr-HA cement was achieved at 3 months as observed by scanning electron microscopy. A high calcium and phosphorus area was observed at the interface of bone-Sr-HA cement determined by energy-dispersive X-ray analysis. Transmission electron microscopy gave evidence of the mechanism of bone formation. Dissolution of Sr-HA into debris by the bone remodeling process was thought to increase the concentration of calcium and phosphorus at the interface of bone-Sr-HA cement and stimulate bone formation. Crystalline Sr-HA formed an amorphous layer and dissolved into the surrounding solution, then apatite crystallites were precipitated and formed new bone at 3 months. This young bone then becomes mature bone, which bonds tightly to the Sr-HA cement with collagen fibers inserted perpendicularly after 6 months. Copyright 2004 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/68970
ISSN
1549-3296
2022 Impact Factor: 4.9
2020 SCImago Journal Rankings: 0.849
ISI Accession Number ID
WOS:000223281100008

 

DC FieldValueLanguage
dc.contributor.authorWong, CTen_HK
dc.contributor.authorChen, QZen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorLeong, JCen_HK
dc.contributor.authorChan, WKen_HK
dc.contributor.authorCheung, KMen_HK
dc.contributor.authorLuk, KDen_HK
dc.date.accessioned2010-09-06T06:09:22Z-
dc.date.available2010-09-06T06:09:22Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Biomedical Materials Research. Part A, 2004, v. 70 A n. 3, p. 428-435en_HK
dc.identifier.issn1549-3296en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68970-
dc.description.abstractThe purpose of this study was to investigate the mineralization leading to osseointegration of strontium-containing hydroxyapatite (Sr-HA) bioactive bone cement injected into cancellous bone in vivo. Sr-HA cement was injected into the ilium of rabbits for 1, 3, and 6 months. The bone mineralization area was found to be largest at 3 months, then at 1 month, and smallest at 6 months (p < 0.01) measured with tetracycline labeling. Osseointegration of Sr-HA cement was achieved at 3 months as observed by scanning electron microscopy. A high calcium and phosphorus area was observed at the interface of bone-Sr-HA cement determined by energy-dispersive X-ray analysis. Transmission electron microscopy gave evidence of the mechanism of bone formation. Dissolution of Sr-HA into debris by the bone remodeling process was thought to increase the concentration of calcium and phosphorus at the interface of bone-Sr-HA cement and stimulate bone formation. Crystalline Sr-HA formed an amorphous layer and dissolved into the surrounding solution, then apatite crystallites were precipitated and formed new bone at 3 months. This young bone then becomes mature bone, which bonds tightly to the Sr-HA cement with collagen fibers inserted perpendicularly after 6 months. Copyright 2004 Wiley Periodicals, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304/en_HK
dc.relation.ispartofJournal of biomedical materials research. Part Aen_HK
dc.rightsJournal of Biomedical Materials Research Part A. Copyright © John Wiley & Sons, Inc.en_HK
dc.titleUltrastructural study of mineralization of a strontium-containing hydroxyapatite (Sr-HA) cement in vivo.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1549-3296&volume=70A&spage=428&epage=435&date=2004&atitle=Ultrastructural+study+of+mineralization+of+a+strontium-containing+hydroxyapatite+(Sr-HA)+cement+in+vivoen_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.emailChan, WK:waichan@hku.hken_HK
dc.identifier.emailCheung, KM:cheungmc@hku.hken_HK
dc.identifier.emailLuk, KD:hcm21000@hku.hken_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.identifier.authorityChan, WK=rp00667en_HK
dc.identifier.authorityCheung, KM=rp00387en_HK
dc.identifier.authorityLuk, KD=rp00333en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jbm.a.30097-
dc.identifier.pmid15293316-
dc.identifier.scopuseid_2-s2.0-16644368407en_HK
dc.identifier.hkuros94021en_HK
dc.identifier.volume70 Aen_HK
dc.identifier.issue3en_HK
dc.identifier.spage428en_HK
dc.identifier.epage435en_HK
dc.identifier.isiWOS:000223281100008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, CT=7404954512en_HK
dc.identifier.scopusauthoridChen, QZ=8353179600en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridLeong, JC=35560782200en_HK
dc.identifier.scopusauthoridChan, WK=13310083000en_HK
dc.identifier.scopusauthoridCheung, KM=7402406754en_HK
dc.identifier.scopusauthoridLuk, KD=7201921573en_HK
dc.identifier.issnl1549-3296-

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