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- Scopus: eid_2-s2.0-0031706057
- PMID: 9730581
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Article: Major biological effects of neurotrophic factors on retinal ganglion cells in mammals
Title | Major biological effects of neurotrophic factors on retinal ganglion cells in mammals |
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Authors | |
Keywords | Intravitreal application Neurite outgrowth Optic nerve transection Viability |
Issue Date | 1998 |
Publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/NSG |
Citation | Biological Signals And Receptors, 1998, v. 7 n. 4, p. 220-226 How to Cite? |
Abstract | The mammalian visual system, particularly retinal ganglion cells, has been used for studying the functions of neurotrophic factors on neurons for many years. The major biological effects of neurotrophic factors on retinal ganglion cells observed so far are the promotion of viability and axonal regeneration. However, there are still some controversies regarding the effects of neurotrophic factors on retinal ganglion cells in the literature. This review is aimed to summarize the available information on the biological actions of these neurotrophic factors on survival and axonal regeneration of retinal ganglion cells and the expressions of neurotrophic factor receptors in the retina. Generally, brain-derived neurotrophic factor, neurotrophin-4/5, fibroblast growth factor and glial cell line-derived neurotrophic factor increase the survival of retinal ganglion cells while the effect of ciliary neurotrophic factor on the viability of adult retinal ganglion cells is controversial. The ciliary neurotrophic factor is the only effective factor in promoting long distance axonal regeneration of retinal ganglion cells whereas brain-derived neurotrophic factor and neurotrophin-4/5 only enhance neurite sprouting within the retina. |
Persistent Identifier | http://hdl.handle.net/10722/67873 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Cui, Q | en_HK |
dc.contributor.author | So, KF | en_HK |
dc.contributor.author | Yip, HK | en_HK |
dc.date.accessioned | 2010-09-06T05:59:03Z | - |
dc.date.available | 2010-09-06T05:59:03Z | - |
dc.date.issued | 1998 | en_HK |
dc.identifier.citation | Biological Signals And Receptors, 1998, v. 7 n. 4, p. 220-226 | en_HK |
dc.identifier.issn | 1422-4933 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/67873 | - |
dc.description.abstract | The mammalian visual system, particularly retinal ganglion cells, has been used for studying the functions of neurotrophic factors on neurons for many years. The major biological effects of neurotrophic factors on retinal ganglion cells observed so far are the promotion of viability and axonal regeneration. However, there are still some controversies regarding the effects of neurotrophic factors on retinal ganglion cells in the literature. This review is aimed to summarize the available information on the biological actions of these neurotrophic factors on survival and axonal regeneration of retinal ganglion cells and the expressions of neurotrophic factor receptors in the retina. Generally, brain-derived neurotrophic factor, neurotrophin-4/5, fibroblast growth factor and glial cell line-derived neurotrophic factor increase the survival of retinal ganglion cells while the effect of ciliary neurotrophic factor on the viability of adult retinal ganglion cells is controversial. The ciliary neurotrophic factor is the only effective factor in promoting long distance axonal regeneration of retinal ganglion cells whereas brain-derived neurotrophic factor and neurotrophin-4/5 only enhance neurite sprouting within the retina. | en_HK |
dc.language | eng | en_HK |
dc.publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/NSG | en_HK |
dc.relation.ispartof | Biological Signals and Receptors | en_HK |
dc.rights | Biological Signals and Receptors. Copyright © S Karger AG. | en_HK |
dc.subject | Intravitreal application | - |
dc.subject | Neurite outgrowth | - |
dc.subject | Optic nerve transection | - |
dc.subject | Viability | - |
dc.subject.mesh | Adult | en_HK |
dc.subject.mesh | Animals | en_HK |
dc.subject.mesh | Axons - drug effects | en_HK |
dc.subject.mesh | Cell Survival - drug effects | en_HK |
dc.subject.mesh | Cytokines - pharmacology | en_HK |
dc.subject.mesh | Denervation | en_HK |
dc.subject.mesh | Growth Substances - pharmacology | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Mammals - physiology | en_HK |
dc.subject.mesh | Nerve Growth Factors - pharmacology | en_HK |
dc.subject.mesh | Nerve Regeneration | en_HK |
dc.subject.mesh | Nerve Transfer | en_HK |
dc.subject.mesh | Neurites - drug effects | en_HK |
dc.subject.mesh | Optic Nerve Injuries | en_HK |
dc.subject.mesh | Receptors, Nerve Growth Factor - drug effects - physiology | en_HK |
dc.subject.mesh | Retinal Ganglion Cells - drug effects | en_HK |
dc.subject.mesh | Schwann Cells - transplantation | en_HK |
dc.subject.mesh | Vitreous Body | en_HK |
dc.title | Major biological effects of neurotrophic factors on retinal ganglion cells in mammals | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1422-4933&volume=7&spage=220&epage=226&date=1998&atitle=Major+biological+effects+of+neurotrophic+factors+on+retinal+ganglion+cells+in+mammals | en_HK |
dc.identifier.email | So, KF:hrmaskf@hkucc.hku.hk | en_HK |
dc.identifier.email | Yip, HK:hkfyip@hku.hk | en_HK |
dc.identifier.authority | So, KF=rp00329 | en_HK |
dc.identifier.authority | Yip, HK=rp00285 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.pmid | 9730581 | - |
dc.identifier.scopus | eid_2-s2.0-0031706057 | en_HK |
dc.identifier.hkuros | 37590 | en_HK |
dc.identifier.volume | 7 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 220 | en_HK |
dc.identifier.epage | 226 | en_HK |
dc.identifier.isi | WOS:000075823300002 | - |
dc.publisher.place | Switzerland | en_HK |
dc.identifier.scopusauthorid | Cui, Q=7103080164 | en_HK |
dc.identifier.scopusauthorid | So, KF=34668391300 | en_HK |
dc.identifier.scopusauthorid | Yip, HK=7101980864 | en_HK |
dc.identifier.issnl | 1422-4933 | - |