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- Publisher Website: 10.1042/BC20060026
- Scopus: eid_2-s2.0-33748647207
- PMID: 16686600
- WOS: WOS:000240705800002
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Article: Id-1 modulates senescence and TGF-β1 sensitivity in prostate epithelial cells
Title | Id-1 modulates senescence and TGF-β1 sensitivity in prostate epithelial cells |
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Authors | |
Keywords | Cell proliferation Downstream effector G2/M cell-cycle arrest Growth arrest Human epithelial cell |
Issue Date | 2006 |
Publisher | Portland Press Ltd. The Journal's web site is located at http://www.biolcell.org/ |
Citation | Biology Of The Cell, 2006, v. 98 n. 9, p. 523-533 How to Cite? |
Abstract | Background information. Loss of sensitivity to TGF-β1 (transforming growth factor β1)-induced growth arrest is an important step towards malignant transformation in human epithelial cells, and Id-1 (inhibitor of differentiation or DNA binding-1) has been associated with cell proliferation and cell-cycle progression. Here, we investigated the role of Id-1 in cellular sensitivity to TGF-β1. Results. Using an immortalized prostate epithelial cell line, NPTX cells, we suppressed Id-1 expression through antisense strategy. We found that inhibition of Id-1 expression suppressed cell proliferation and at the same time induced cellular senescence and G2/M cell-cycle arrest. In addition, inactivation of Id-1 made cells more vulnerable to TGF-β1-induced growth arrest. The sensitization effect on TGF-β1 was associated with up-regulation of two downstream effectors of the TGF-β1 pathway, p21WAF1/Cip1 and p27KIP1. Conclusion. Our results indicate that endogenous Id-1 levels might be a crucial factor in the development of resistance to TGF-β1-induced growth suppression in human prostate epithelial cells. |
Persistent Identifier | http://hdl.handle.net/10722/67844 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.862 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Di, K | en_HK |
dc.contributor.author | Ling, MT | en_HK |
dc.contributor.author | Tsao, SW | en_HK |
dc.contributor.author | Wong, YC | en_HK |
dc.contributor.author | Wang, X | en_HK |
dc.date.accessioned | 2010-09-06T05:58:47Z | - |
dc.date.available | 2010-09-06T05:58:47Z | - |
dc.date.issued | 2006 | en_HK |
dc.identifier.citation | Biology Of The Cell, 2006, v. 98 n. 9, p. 523-533 | en_HK |
dc.identifier.issn | 0248-4900 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/67844 | - |
dc.description.abstract | Background information. Loss of sensitivity to TGF-β1 (transforming growth factor β1)-induced growth arrest is an important step towards malignant transformation in human epithelial cells, and Id-1 (inhibitor of differentiation or DNA binding-1) has been associated with cell proliferation and cell-cycle progression. Here, we investigated the role of Id-1 in cellular sensitivity to TGF-β1. Results. Using an immortalized prostate epithelial cell line, NPTX cells, we suppressed Id-1 expression through antisense strategy. We found that inhibition of Id-1 expression suppressed cell proliferation and at the same time induced cellular senescence and G2/M cell-cycle arrest. In addition, inactivation of Id-1 made cells more vulnerable to TGF-β1-induced growth arrest. The sensitization effect on TGF-β1 was associated with up-regulation of two downstream effectors of the TGF-β1 pathway, p21WAF1/Cip1 and p27KIP1. Conclusion. Our results indicate that endogenous Id-1 levels might be a crucial factor in the development of resistance to TGF-β1-induced growth suppression in human prostate epithelial cells. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Portland Press Ltd. The Journal's web site is located at http://www.biolcell.org/ | en_HK |
dc.relation.ispartof | Biology of the Cell | en_HK |
dc.subject | Cell proliferation | - |
dc.subject | Downstream effector | - |
dc.subject | G2/M cell-cycle arrest | - |
dc.subject | Growth arrest | - |
dc.subject | Human epithelial cell | - |
dc.subject.mesh | Cell Aging - drug effects - genetics | en_HK |
dc.subject.mesh | Cell Division - drug effects - genetics | en_HK |
dc.subject.mesh | Cell Line, Transformed | en_HK |
dc.subject.mesh | Cyclin-Dependent Kinase Inhibitor p21 - genetics - metabolism | en_HK |
dc.subject.mesh | Epithelial Cells - cytology - metabolism | en_HK |
dc.subject.mesh | G2 Phase - drug effects - genetics | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Inhibitor of Differentiation Protein 1 - biosynthesis - genetics | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Prostate - cytology - metabolism | en_HK |
dc.subject.mesh | Signal Transduction - drug effects - genetics | en_HK |
dc.subject.mesh | Transforming Growth Factor beta - metabolism - pharmacology | en_HK |
dc.subject.mesh | Transforming Growth Factor beta1 | en_HK |
dc.subject.mesh | Up-Regulation - drug effects - genetics | en_HK |
dc.title | Id-1 modulates senescence and TGF-β1 sensitivity in prostate epithelial cells | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0248-4900&volume=98&spage=523&epage=533.&date=2006&atitle=Id-1+modulates+senescence+and+TGF-β1+sensitivity+in+prostate+epithelial+cells.+ | en_HK |
dc.identifier.email | Ling, MT:patling@hkucc.hku.hk | en_HK |
dc.identifier.email | Tsao, SW:gswtsao@hkucc.hku.hk | en_HK |
dc.identifier.email | Wong, YC:ycwong@hkucc.hku.hk | en_HK |
dc.identifier.authority | Ling, MT=rp00449 | en_HK |
dc.identifier.authority | Tsao, SW=rp00399 | en_HK |
dc.identifier.authority | Wong, YC=rp00316 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1042/BC20060026 | en_HK |
dc.identifier.pmid | 16686600 | - |
dc.identifier.scopus | eid_2-s2.0-33748647207 | en_HK |
dc.identifier.hkuros | 133113 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33748647207&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 98 | en_HK |
dc.identifier.issue | 9 | en_HK |
dc.identifier.spage | 523 | en_HK |
dc.identifier.epage | 533 | en_HK |
dc.identifier.isi | WOS:000240705800002 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Di, K=14526710900 | en_HK |
dc.identifier.scopusauthorid | Ling, MT=7102229780 | en_HK |
dc.identifier.scopusauthorid | Tsao, SW=7102813116 | en_HK |
dc.identifier.scopusauthorid | Wong, YC=7403041798 | en_HK |
dc.identifier.scopusauthorid | Wang, X=7501854829 | en_HK |
dc.identifier.issnl | 0248-4900 | - |