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- Publisher Website: 10.1038/nm1529
- Scopus: eid_2-s2.0-33846995616
- PMID: 17206149
- WOS: WOS:000244031700022
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Article: Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract
Title | Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract |
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Authors | |
Issue Date | 2007 |
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/nm |
Citation | Nature Medicine, 2007, v. 13 n. 2, p. 147-149 How to Cite? |
Abstract | Poor human-to-human transmission of influenza A H5N1 virus has been attributed to the paucity of putative sialic acid α2-3 virus receptors in the epithelium of the human upper respiratory tract, and thus to the presumed inability of the virus to replicate efficiently at this site. We now demonstrate that ex vivo cultures of human nasopharyngeal, adenoid and tonsillar tissues can be infected with H5N1 viruses in spite of an apparent lack of these receptors. © 2007 Nature Publishing Group. |
Persistent Identifier | http://hdl.handle.net/10722/67689 |
ISSN | 2023 Impact Factor: 58.7 2023 SCImago Journal Rankings: 19.045 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nicholls, JM | en_HK |
dc.contributor.author | Chan, MCW | en_HK |
dc.contributor.author | Chan, WY | en_HK |
dc.contributor.author | Wong, HK | en_HK |
dc.contributor.author | Cheung, CY | en_HK |
dc.contributor.author | Kwong, DLW | en_HK |
dc.contributor.author | Wong, MP | en_HK |
dc.contributor.author | Chui, WH | en_HK |
dc.contributor.author | Poon, LLM | en_HK |
dc.contributor.author | Tsao, SW | en_HK |
dc.contributor.author | Guan, Y | en_HK |
dc.contributor.author | Peiris, JSM | en_HK |
dc.date.accessioned | 2010-09-06T05:57:22Z | - |
dc.date.available | 2010-09-06T05:57:22Z | - |
dc.date.issued | 2007 | en_HK |
dc.identifier.citation | Nature Medicine, 2007, v. 13 n. 2, p. 147-149 | en_HK |
dc.identifier.issn | 1078-8956 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/67689 | - |
dc.description.abstract | Poor human-to-human transmission of influenza A H5N1 virus has been attributed to the paucity of putative sialic acid α2-3 virus receptors in the epithelium of the human upper respiratory tract, and thus to the presumed inability of the virus to replicate efficiently at this site. We now demonstrate that ex vivo cultures of human nasopharyngeal, adenoid and tonsillar tissues can be infected with H5N1 viruses in spite of an apparent lack of these receptors. © 2007 Nature Publishing Group. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/nm | en_HK |
dc.relation.ispartof | Nature Medicine | en_HK |
dc.subject.mesh | Influenza A Virus, H5N1 Subtype - metabolism | - |
dc.subject.mesh | Influenza, Human - metabolism - transmission | - |
dc.subject.mesh | Receptors, Cell Surface - metabolism | - |
dc.subject.mesh | Respiratory System - virology | - |
dc.subject.mesh | Virus Attachment | - |
dc.title | Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Nicholls, JM: jmnichol@hkucc.hku.hk | en_HK |
dc.identifier.email | Chan, MCW: mchan@hku.hk | en_HK |
dc.identifier.email | Chan, WY: reneewy@hku.hk | en_HK |
dc.identifier.email | Cheung, CY: chungey@hkucc.hku.hk | en_HK |
dc.identifier.email | Kwong, DLW: dlwkwong@hku.hk | en_HK |
dc.identifier.email | Wong, MP: mwpik@hkucc.hku.hk | en_HK |
dc.identifier.email | Poon, LLM: llmpoon@hkucc.hku.hk | en_HK |
dc.identifier.email | Tsao, SW: gswtsao@hku.hk | en_HK |
dc.identifier.email | Guan, Y: yguan@hkucc.hku.hk | en_HK |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | en_HK |
dc.identifier.authority | Nicholls, JM=rp00364 | en_HK |
dc.identifier.authority | Chan, MCW=rp00420 | en_HK |
dc.identifier.authority | Chan, WY=rp01596 | en_HK |
dc.identifier.authority | Cheung, CY=rp00404 | en_HK |
dc.identifier.authority | Kwong, DLW=rp00414 | en_HK |
dc.identifier.authority | Wong, MP=rp00348 | en_HK |
dc.identifier.authority | Poon, LLM=rp00484 | en_HK |
dc.identifier.authority | Tsao, SW=rp00399 | en_HK |
dc.identifier.authority | Guan, Y=rp00397 | en_HK |
dc.identifier.authority | Peiris, JSM=rp00410 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1038/nm1529 | en_HK |
dc.identifier.pmid | 17206149 | - |
dc.identifier.scopus | eid_2-s2.0-33846995616 | en_HK |
dc.identifier.hkuros | 151573 | - |
dc.identifier.hkuros | 126056 | - |
dc.identifier.hkuros | 140437 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33846995616&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 13 | en_HK |
dc.identifier.issue | 2 | en_HK |
dc.identifier.spage | 147 | en_HK |
dc.identifier.epage | 149 | en_HK |
dc.identifier.eissn | 1546-170X | - |
dc.identifier.isi | WOS:000244031700022 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Nicholls, JM=7201463077 | en_HK |
dc.identifier.scopusauthorid | Chan, MCW=26654715500 | en_HK |
dc.identifier.scopusauthorid | Chan, WY=26661379100 | en_HK |
dc.identifier.scopusauthorid | Wong, HK=12761383400 | en_HK |
dc.identifier.scopusauthorid | Cheung, CY=7202061836 | en_HK |
dc.identifier.scopusauthorid | Kwong, DLW=15744231600 | en_HK |
dc.identifier.scopusauthorid | Wong, MP=7403907887 | en_HK |
dc.identifier.scopusauthorid | Chui, WH=7003524497 | en_HK |
dc.identifier.scopusauthorid | Poon, LLM=7005441747 | en_HK |
dc.identifier.scopusauthorid | Tsao, SW=7102813116 | en_HK |
dc.identifier.scopusauthorid | Guan, Y=7202924055 | en_HK |
dc.identifier.scopusauthorid | Peiris, JSM=7005486823 | en_HK |
dc.identifier.citeulike | 1091781 | - |
dc.identifier.issnl | 1078-8956 | - |