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- Publisher Website: 10.1002/ptr.3049
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- PMID: 19953524
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Article: Effect of Buguzhi (Psoralea corylifolia fruit) extract on bone formation
Title | Effect of Buguzhi (Psoralea corylifolia fruit) extract on bone formation | ||||
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Authors | |||||
Keywords | Bone graft Buguzhi extract Collagen | ||||
Issue Date | 2010 | ||||
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/12567 | ||||
Citation | Phytotherapy Research, 2010, v. 24 SUPPL. 2, p. S155-S160 How to Cite? | ||||
Abstract | The objective of the study is to compare the amount of new bone produced by Buguzhi (Psoralea corylifolia fruit) extract in collagen matrix to that produced and collagen matrix in vivo. Eighteen bone defects, 5 mm by 10 mm, were created in the parietal bone of 9 New Zealand white rabbits. Six defects were grafted with Buguzhi extract mixed with collagen matrix. Six defects were grafted with collagen matrix alone (positive control) and 6 were left empty (negative control). Animals were sacrificed on day 14 and the defects were dissected and prepared for histological assessment. Quantitative analysis of new bone formation and bone cells was made on 100 sections (50 sections for each group) using image analysis. A total of 275% more new bone was present in defects grafted with Buguzhi extract in collagen matrix than those grafted with collagen matrix. No bone was formed in the negative control group. The amount of bone cells was also significantly greater in the Buguzhi group than in the positive control group. To conclude, Buguzhi extract in collagen matrix has the effect of increasing new bone formation locally in vivo. Buguzhi extract in collagen matrix can be used as a bone graft material. Copyright © 2009 John Wiley & Sons, Ltd. | ||||
Persistent Identifier | http://hdl.handle.net/10722/67093 | ||||
ISSN | 2023 Impact Factor: 6.1 2023 SCImago Journal Rankings: 1.277 | ||||
ISI Accession Number ID |
Funding Information: This study was funded by University Research Grant No: 10208640/36170/08000/310/01, the University of Hong Kong. | ||||
References | |||||
Errata |
DC Field | Value | Language |
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dc.contributor.author | Wong, RWK | en_HK |
dc.contributor.author | Rabie, ABM | en_HK |
dc.date.accessioned | 2010-09-06T05:51:54Z | - |
dc.date.available | 2010-09-06T05:51:54Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | Phytotherapy Research, 2010, v. 24 SUPPL. 2, p. S155-S160 | en_HK |
dc.identifier.issn | 0951-418X | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/67093 | - |
dc.description.abstract | The objective of the study is to compare the amount of new bone produced by Buguzhi (Psoralea corylifolia fruit) extract in collagen matrix to that produced and collagen matrix in vivo. Eighteen bone defects, 5 mm by 10 mm, were created in the parietal bone of 9 New Zealand white rabbits. Six defects were grafted with Buguzhi extract mixed with collagen matrix. Six defects were grafted with collagen matrix alone (positive control) and 6 were left empty (negative control). Animals were sacrificed on day 14 and the defects were dissected and prepared for histological assessment. Quantitative analysis of new bone formation and bone cells was made on 100 sections (50 sections for each group) using image analysis. A total of 275% more new bone was present in defects grafted with Buguzhi extract in collagen matrix than those grafted with collagen matrix. No bone was formed in the negative control group. The amount of bone cells was also significantly greater in the Buguzhi group than in the positive control group. To conclude, Buguzhi extract in collagen matrix has the effect of increasing new bone formation locally in vivo. Buguzhi extract in collagen matrix can be used as a bone graft material. Copyright © 2009 John Wiley & Sons, Ltd. | en_HK |
dc.language | eng | en_HK |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/12567 | en_HK |
dc.relation.ispartof | Phytotherapy Research | en_HK |
dc.rights | Phytotherapy Research. Copyright © John Wiley & Sons Ltd. | en_HK |
dc.subject | Bone graft | en_HK |
dc.subject | Buguzhi extract | en_HK |
dc.subject | Collagen | en_HK |
dc.subject.mesh | Animals | en_HK |
dc.subject.mesh | Collagen - pharmacology | en_HK |
dc.subject.mesh | Drugs, Chinese Herbal - pharmacology | en_HK |
dc.subject.mesh | Fruit - chemistry | en_HK |
dc.subject.mesh | Osteogenesis - drug effects | en_HK |
dc.subject.mesh | Parietal Bone - drug effects - pathology | en_HK |
dc.subject.mesh | Plant Extracts - pharmacology | en_HK |
dc.subject.mesh | Psoralea - chemistry | en_HK |
dc.subject.mesh | Rabbits | en_HK |
dc.title | Effect of Buguzhi (Psoralea corylifolia fruit) extract on bone formation | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Wong, RWK: fyoung@hku.hk | en_HK |
dc.identifier.email | Rabie, ABM: rabie@hku.hk | en_HK |
dc.identifier.authority | Wong, RWK=rp00038 | en_HK |
dc.identifier.authority | Rabie, ABM=rp00029 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/ptr.3049 | en_HK |
dc.identifier.pmid | 19953524 | - |
dc.identifier.scopus | eid_2-s2.0-77953895506 | en_HK |
dc.identifier.hkuros | 168355 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77953895506&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 24 | en_HK |
dc.identifier.issue | SUPPL. 2 | en_HK |
dc.identifier.spage | S155 | en_HK |
dc.identifier.epage | S160 | en_HK |
dc.identifier.isi | WOS:000279801000006 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.relation.erratum | doi:10.1002/ptr.3253 | - |
dc.identifier.scopusauthorid | Wong, RWK=7402127170 | en_HK |
dc.identifier.scopusauthorid | Rabie, ABM=7007172734 | en_HK |
dc.identifier.issnl | 0951-418X | - |