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Conference Paper: Influence of nicotine on blood perfusion and bone healing during distraction osteogenesis.

TitleInfluence of nicotine on blood perfusion and bone healing during distraction osteogenesis.
Authors
Ma, LZheng, LWCheung, LK
Issue Date2008
PublisherRoyal Australasian College of Dental Surgeons. The Journal's web site is located at http://www.racds.org
Citation
Annals Of The Royal Australasian College Of Dental Surgeons, 2008, v. 19, p. 52-54 How to Cite?
AbstractNicotine is the main chemical component in tobacco products and its effect on bone healing remains controversial. This study aims to evaluate the influence of nicotine on blood perfusion and bone healing using a rabbit model of mandibular distraction osteogenesis. The dose dependent effect of nicotine on bone regeneration, and the effect of nicotine on blood perfusion and angiogenesis were assessed by radiography, micro-computed tomography, histological and immunohistochemical analysis, real time PCR and Laser Doppler monitoring. Results showed that bone healing was compromised by high dose nicotine treatment. Nicotine exposure increased microvessel density, whereas inhibited blood flow and bone formation. The expression of bone morphogenetic protein (BMP)-2 in osteoblasts was also decreased. The present study supported that nicotine has a dose dependant influence on bone healing in distraction osteogenesis. Nicotine compromises bone regeneration possibly by causing ischemia and inhibiting BMP expression in osteoblasts. Nicotine exposure enhances angiogenesis but can not compensate for the adverse effect of vasoconstriction.
Persistent Identifierhttp://hdl.handle.net/10722/66891
ISSN
0158-1570

 

DC FieldValueLanguage
dc.contributor.authorMa, Len_HK
dc.contributor.authorZheng, LWen_HK
dc.contributor.authorCheung, LKen_HK
dc.date.accessioned2010-09-06T05:50:13Z-
dc.date.available2010-09-06T05:50:13Z-
dc.date.issued2008en_HK
dc.identifier.citationAnnals Of The Royal Australasian College Of Dental Surgeons, 2008, v. 19, p. 52-54en_HK
dc.identifier.issn0158-1570en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66891-
dc.description.abstractNicotine is the main chemical component in tobacco products and its effect on bone healing remains controversial. This study aims to evaluate the influence of nicotine on blood perfusion and bone healing using a rabbit model of mandibular distraction osteogenesis. The dose dependent effect of nicotine on bone regeneration, and the effect of nicotine on blood perfusion and angiogenesis were assessed by radiography, micro-computed tomography, histological and immunohistochemical analysis, real time PCR and Laser Doppler monitoring. Results showed that bone healing was compromised by high dose nicotine treatment. Nicotine exposure increased microvessel density, whereas inhibited blood flow and bone formation. The expression of bone morphogenetic protein (BMP)-2 in osteoblasts was also decreased. The present study supported that nicotine has a dose dependant influence on bone healing in distraction osteogenesis. Nicotine compromises bone regeneration possibly by causing ischemia and inhibiting BMP expression in osteoblasts. Nicotine exposure enhances angiogenesis but can not compensate for the adverse effect of vasoconstriction.en_HK
dc.languageengen_HK
dc.publisherRoyal Australasian College of Dental Surgeons. The Journal's web site is located at http://www.racds.orgen_HK
dc.relation.ispartofAnnals of the Royal Australasian College of Dental Surgeonsen_HK
dc.subject.meshBone Regeneration - drug effects-
dc.subject.meshMandible - blood supply - radiography - surgery-
dc.subject.meshNicotine - administration and dosage - blood - pharmacology-
dc.subject.meshNicotinic Agonists - administration and dosage - blood - pharmacology-
dc.subject.meshOsteogenesis, Distraction - methods-
dc.titleInfluence of nicotine on blood perfusion and bone healing during distraction osteogenesis.en_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0158-1570&volume=19&spage=52&epage=54&date=2008&atitle=Influence+of+nicotine+on+blood+perfusion+and+bone+healing+during+distraction+osteogenesisen_HK
dc.identifier.emailZheng, LW:lwzheng@hku.hken_HK
dc.identifier.emailCheung, LK:lkcheung@hkucc.hku.hken_HK
dc.identifier.authorityZheng, LW=rp01411en_HK
dc.identifier.authorityCheung, LK=rp00013en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid19728631-
dc.identifier.scopuseid_2-s2.0-70349758775en_HK
dc.identifier.hkuros169502en_HK
dc.identifier.volume19en_HK
dc.identifier.spage52en_HK
dc.identifier.epage54en_HK
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridMa, L=36071946000en_HK
dc.identifier.scopusauthoridZheng, LW=11241247300en_HK
dc.identifier.scopusauthoridCheung, LK=7102302747en_HK
dc.identifier.issnl0158-1570-

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