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Article: Clindamycin in dentistry: More than just effective prophylaxis for endocarditis?

TitleClindamycin in dentistry: More than just effective prophylaxis for endocarditis?
Authors
Brook, ILewis, MAOSándor, GKBJeffcoat, MSamaranayake, LPRojas, JV
Issue Date2005
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/tripleo
Citation
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology And Endodontology, 2005, v. 100 n. 5, p. 550-558 How to Cite?
DOI: http://dx.doi.org/10.1016/j.tripleo.2005.02.086
AbstractClindamycin is a broad-spectrum antibiotic with activity against aerobic, anaerobic, and β-lactamase-producing pathogens. This antibiotic has been used for many years as prophylactic treatment during dental procedures to prevent endocarditis. However, the spectrum and susceptibility of the bacteria species involved in dental infections indicate that clindamycin would also be an effective treatment option for these conditions. In addition to its antiinfective properties, clindamycin has high oral absorption, significant tissue penetration, including penetration into bone, and stimulatory effects on the host immune system. This review discusses the microbiologic and clinical evidence supporting the efficacy and safety of clindamycin for the successful management of dental infections. © 2005 Mosby, Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/65851
ISSN
1079-2104
2011 Impact Factor: 1.457
ISI Accession Number ID
WOS:000233029600005
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorBrook, Ien_HK
dc.contributor.authorLewis, MAOen_HK
dc.contributor.authorSándor, GKBen_HK
dc.contributor.authorJeffcoat, Men_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.contributor.authorRojas, JVen_HK
dc.date.accessioned2010-09-06T05:41:31Z-
dc.date.available2010-09-06T05:41:31Z-
dc.date.issued2005en_HK
dc.identifier.citationOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology And Endodontology, 2005, v. 100 n. 5, p. 550-558en_HK
dc.identifier.issn1079-2104en_HK
dc.identifier.urihttp://hdl.handle.net/10722/65851-
dc.description.abstractClindamycin is a broad-spectrum antibiotic with activity against aerobic, anaerobic, and β-lactamase-producing pathogens. This antibiotic has been used for many years as prophylactic treatment during dental procedures to prevent endocarditis. However, the spectrum and susceptibility of the bacteria species involved in dental infections indicate that clindamycin would also be an effective treatment option for these conditions. In addition to its antiinfective properties, clindamycin has high oral absorption, significant tissue penetration, including penetration into bone, and stimulatory effects on the host immune system. This review discusses the microbiologic and clinical evidence supporting the efficacy and safety of clindamycin for the successful management of dental infections. © 2005 Mosby, Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/tripleoen_HK
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontologyen_HK
dc.rightsOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. Copyright © Mosby, Inc.en_HK
dc.subject.meshAnti-Bacterial Agents - pharmacokinetics - pharmacology - therapeutic useen_HK
dc.subject.meshAntibiotic Prophylaxisen_HK
dc.subject.meshBacteria, Anaerobic - drug effectsen_HK
dc.subject.meshClindamycin - pharmacokinetics - pharmacology - therapeutic useen_HK
dc.subject.meshDental Implants - adverse effectsen_HK
dc.subject.meshDental Pulp Diseases - drug therapy - microbiologyen_HK
dc.subject.meshDrug Resistance, Bacterialen_HK
dc.subject.meshEndocarditis, Bacterial - prevention & controlen_HK
dc.subject.meshFocal Infection, Dental - drug therapy - microbiologyen_HK
dc.subject.meshGram-Negative Bacteria - drug effectsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshPeriodontitis - drug therapy - etiology - microbiologyen_HK
dc.titleClindamycin in dentistry: More than just effective prophylaxis for endocarditis?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1079-2104&volume=100&spage=550&epage=8&date=2006&atitle=Clindamycin+in+dentistry:+More+than+just+effective+prophylaxis+for+endocarditis?en_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.tripleo.2005.02.086en_HK
dc.identifier.pmid16243239-
dc.identifier.scopuseid_2-s2.0-26944441658en_HK
dc.identifier.hkuros113070en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-26944441658&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume100en_HK
dc.identifier.issue5en_HK
dc.identifier.spage550en_HK
dc.identifier.epage558en_HK
dc.identifier.isiWOS:000233029600005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridBrook, I=35427587900en_HK
dc.identifier.scopusauthoridLewis, MAO=7404189187en_HK
dc.identifier.scopusauthoridSándor, GKB=7103117331en_HK
dc.identifier.scopusauthoridJeffcoat, M=7102550396en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK
dc.identifier.scopusauthoridRojas, JV=8899528900en_HK
dc.identifier.issnl1079-2104-

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