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Article: High resolution pair-distance distribution function P (r) of protein solutions

TitleHigh resolution pair-distance distribution function P (r) of protein solutions
Authors
KeywordsBond length
Distribution functions
Polyvinyl alcohols
Scattering
Issue Date2009
PublisherAmerican Institute of Physics. The Journal's web site is located at http://apl.aip.org/
Citation
Applied Physics Letters, 2009, v. 94 n. 8, article no. 083903 How to Cite?
AbstractA high resolution pair-distance distribution function P (r) of protein molecules has been obtained from the complete solution scattering curve made by combining accurate small-angle and wide-angle x-ray scattering data out to 2.15 Å resolution. Both indirect and direct Fourier transforms exhibit two distinct peaks at 1.4 and 5.1 Å in P (r). X-ray crystallographic data demonstrate that these peaks correspond to two intramolecular distances: the average bond length between C, N, and O atoms and the pitch of an α -helix, respectively. Hence some high resolution aspects of the structure and function of a protein may be investigated in a solution. © 2009 American Institute of Physics.
Persistent Identifierhttp://hdl.handle.net/10722/59683
ISSN
2023 Impact Factor: 3.5
2023 SCImago Journal Rankings: 0.976
ISI Accession Number ID
Funding AgencyGrant Number
NSF
NIH/ NIGMSDMR-0225180
NIH/NCRRRR-01646
Funding Information:

We thank M. Szebenyi for critical reading of the manuscript. CHESS is supported by NSF and NIH/ NIGMS via NSF Award No. DMR-0225180 and MacCHESS by NIH/NCRR Award No. RR-01646.

References

 

DC FieldValueLanguage
dc.contributor.authorHong, Xen_HK
dc.contributor.authorHao, Qen_HK
dc.date.accessioned2010-05-31T03:55:11Z-
dc.date.available2010-05-31T03:55:11Z-
dc.date.issued2009en_HK
dc.identifier.citationApplied Physics Letters, 2009, v. 94 n. 8, article no. 083903-
dc.identifier.issn0003-6951en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59683-
dc.description.abstractA high resolution pair-distance distribution function P (r) of protein molecules has been obtained from the complete solution scattering curve made by combining accurate small-angle and wide-angle x-ray scattering data out to 2.15 Å resolution. Both indirect and direct Fourier transforms exhibit two distinct peaks at 1.4 and 5.1 Å in P (r). X-ray crystallographic data demonstrate that these peaks correspond to two intramolecular distances: the average bond length between C, N, and O atoms and the pitch of an α -helix, respectively. Hence some high resolution aspects of the structure and function of a protein may be investigated in a solution. © 2009 American Institute of Physics.en_HK
dc.languageengen_HK
dc.publisherAmerican Institute of Physics. The Journal's web site is located at http://apl.aip.org/en_HK
dc.relation.ispartofApplied Physics Lettersen_HK
dc.subjectBond lengthen_HK
dc.subjectDistribution functionsen_HK
dc.subjectPolyvinyl alcoholsen_HK
dc.subjectScatteringen_HK
dc.titleHigh resolution pair-distance distribution function P (r) of protein solutionsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-6951&volume=94&spage=083903&epage=&date=2009&atitle=High+resolution+pair-distance+distribution+function+P(r)+of+protein+solutionsen_HK
dc.identifier.emailHao, Q: qhao@hku.hken_HK
dc.identifier.authorityHao, Q=rp01332en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1063/1.3089360en_HK
dc.identifier.scopuseid_2-s2.0-61349204558en_HK
dc.identifier.hkuros155964en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-61349204558&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume94en_HK
dc.identifier.issue8en_HK
dc.identifier.spagearticle no. 083903-
dc.identifier.epagearticle no. 083903-
dc.identifier.isiWOS:000263804400094-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHong, X=7201551709en_HK
dc.identifier.scopusauthoridHao, Q=7102508868en_HK
dc.identifier.issnl0003-6951-

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