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Article: Endothelium-dependent contractions: When a good guy turns bad!

TitleEndothelium-dependent contractions: When a good guy turns bad!
Authors
Issue Date2008
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3751
Citation
Journal Of Physiology, 2008, v. 586 n. 22, p. 5295-5304 How to Cite?
AbstractEndothelial cells can induce contractions of the underlying vascular smooth muscle by generating vasoconstrictor prostanoids (endothelium-dependent contracting factor; EDCF). The endothelial COX-1 isoform of cyclooxygenase appears to play the dominant role in the phenomenon. Its activation requires an increase in intracellular Ca2+ concentration. The production of EDCF is inhibited acutely and chronically by nitric oxide (NO), and possibly by endothelium-dependent hyperpolarizing factor (EDHF). The main prostanoids involved in endothelium-dependent contractions appear to be endoperoxides (PGH2) and prostacyclin, which activate thromboxane-prostanoid (TP) receptors of the vascular smooth muscle cells. Oxygen-derived free radicals can facilitate the production and/or the action of EDCF. Endothelium-dependent contractions are exacerbated by ageing, obesity, hypertension and diabetes, and thus are likely to contribute to the endothelial dysfunction observed in older people and in essential hypertensive patients. © 2008 The Authors. Journal compilation © 2008 The Physiological Society.
Persistent Identifierhttp://hdl.handle.net/10722/59554
ISSN
2023 Impact Factor: 4.7
2023 SCImago Journal Rankings: 1.708
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_HK
dc.contributor.authorTang, EHCen_HK
dc.date.accessioned2010-05-31T03:52:36Z-
dc.date.available2010-05-31T03:52:36Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Physiology, 2008, v. 586 n. 22, p. 5295-5304en_HK
dc.identifier.issn0022-3751en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59554-
dc.description.abstractEndothelial cells can induce contractions of the underlying vascular smooth muscle by generating vasoconstrictor prostanoids (endothelium-dependent contracting factor; EDCF). The endothelial COX-1 isoform of cyclooxygenase appears to play the dominant role in the phenomenon. Its activation requires an increase in intracellular Ca2+ concentration. The production of EDCF is inhibited acutely and chronically by nitric oxide (NO), and possibly by endothelium-dependent hyperpolarizing factor (EDHF). The main prostanoids involved in endothelium-dependent contractions appear to be endoperoxides (PGH2) and prostacyclin, which activate thromboxane-prostanoid (TP) receptors of the vascular smooth muscle cells. Oxygen-derived free radicals can facilitate the production and/or the action of EDCF. Endothelium-dependent contractions are exacerbated by ageing, obesity, hypertension and diabetes, and thus are likely to contribute to the endothelial dysfunction observed in older people and in essential hypertensive patients. © 2008 The Authors. Journal compilation © 2008 The Physiological Society.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3751en_HK
dc.relation.ispartofJournal of Physiologyen_HK
dc.rightsThe Journal of Physiology. Copyright © Blackwell Publishing Ltd.en_HK
dc.titleEndothelium-dependent contractions: When a good guy turns bad!en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3751&volume=2008, 586&issue=22&spage=5295&epage=5304&date=2008&atitle=Endothelium-dependent+contractions:+when+a+good+guy+turns+bad!en_HK
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_HK
dc.identifier.emailTang, EHC: evatang1@hku.hken_HK
dc.identifier.authorityVanhoutte, PM=rp00238en_HK
dc.identifier.authorityTang, EHC=rp01382en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1113/jphysiol.2008.161430en_HK
dc.identifier.pmid18818246-
dc.identifier.pmcidPMC2655387-
dc.identifier.scopuseid_2-s2.0-56649094583en_HK
dc.identifier.hkuros166664en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-56649094583&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume586en_HK
dc.identifier.issue22en_HK
dc.identifier.spage5295en_HK
dc.identifier.epage5304en_HK
dc.identifier.isiWOS:000261274600008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_HK
dc.identifier.scopusauthoridTang, EHC=9536518500en_HK
dc.identifier.citeulike3657447-
dc.identifier.issnl0022-3751-

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