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- Publisher Website: 10.1002/eji.200838657
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- PMID: 19197937
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Article: Differences in Bcl-2 expression by T-cell subsets alter their balance after in vivo irradiation to favor CD4+Bcl-2hi NKT cells
Title | Differences in Bcl-2 expression by T-cell subsets alter their balance after in vivo irradiation to favor CD4+Bcl-2hi NKT cells |
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Authors | |
Keywords | Graft vs Host Disease - immunology - metabolism Interleukin-4 - immunology - metabolism Natural Killer T-Cells - immunology - metabolism - radiation effects Proto-Oncogene Proteins c-bcl-2 - immunology - metabolism T-Lymphocyte Subsets - immunology - metabolism - radiation effects |
Issue Date | 2009 |
Publisher | Wiley - VCH Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.eji.de |
Citation | European Journal of Immunology, 2009, v. 39 n. 3, p. 763-775 How to Cite? |
Abstract | Although it is well known that in vivo radiation depletes immune cells via the Bcl-2 apoptotic pathway, a more nuanced analysis of the changes in the balance of immune-cell subsets is needed to understand the impact of radiation on immune function. We show the balance of T-cell subsets changes after increasing single doses of total body irradiation (TBI) or after fractionated irradiation of the lymphoid tissues (TLI) of mice due to differences in radioresistance and Bcl-2 expression of the NKT-cell and non-NKT subsets to favor CD4(+)Bcl-2(hi) NKT cells. Reduction of the Bcl-2(lo) mature T-cell subsets was at least 100-fold greater than that of the Bcl-2(hi) subsets. CD4(+) NKT cells upregulated Bcl-2 after TBI and TLI and developed a Th2 bias after TLI, whereas non-NKT cells failed to do so. Our previous studies showed TLI protects against graft versus host disease in wild-type, but not in NKT-cell-deficient mice. The present study shows that NKT cells have a protective function even after TBI, and these cells are tenfold more abundant after an equal dose of TLI. In conclusion, differential expression of Bcl-2 contributes to the changes in T-cell subsets and immune function after irradiation. |
Persistent Identifier | http://hdl.handle.net/10722/59515 |
ISSN | 2023 Impact Factor: 4.5 2023 SCImago Journal Rankings: 1.627 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yao, Z | en_HK |
dc.contributor.author | Liu, Y | en_HK |
dc.contributor.author | Jones, J | en_HK |
dc.contributor.author | Strober, S | - |
dc.date.accessioned | 2010-05-31T03:51:48Z | - |
dc.date.available | 2010-05-31T03:51:48Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | European Journal of Immunology, 2009, v. 39 n. 3, p. 763-775 | en_HK |
dc.identifier.issn | 0014-2980 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/59515 | - |
dc.description.abstract | Although it is well known that in vivo radiation depletes immune cells via the Bcl-2 apoptotic pathway, a more nuanced analysis of the changes in the balance of immune-cell subsets is needed to understand the impact of radiation on immune function. We show the balance of T-cell subsets changes after increasing single doses of total body irradiation (TBI) or after fractionated irradiation of the lymphoid tissues (TLI) of mice due to differences in radioresistance and Bcl-2 expression of the NKT-cell and non-NKT subsets to favor CD4(+)Bcl-2(hi) NKT cells. Reduction of the Bcl-2(lo) mature T-cell subsets was at least 100-fold greater than that of the Bcl-2(hi) subsets. CD4(+) NKT cells upregulated Bcl-2 after TBI and TLI and developed a Th2 bias after TLI, whereas non-NKT cells failed to do so. Our previous studies showed TLI protects against graft versus host disease in wild-type, but not in NKT-cell-deficient mice. The present study shows that NKT cells have a protective function even after TBI, and these cells are tenfold more abundant after an equal dose of TLI. In conclusion, differential expression of Bcl-2 contributes to the changes in T-cell subsets and immune function after irradiation. | - |
dc.language | eng | en_HK |
dc.publisher | Wiley - VCH Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.eji.de | en_HK |
dc.relation.ispartof | European Journal of Immunology | en_HK |
dc.subject | Graft vs Host Disease - immunology - metabolism | - |
dc.subject | Interleukin-4 - immunology - metabolism | - |
dc.subject | Natural Killer T-Cells - immunology - metabolism - radiation effects | - |
dc.subject | Proto-Oncogene Proteins c-bcl-2 - immunology - metabolism | - |
dc.subject | T-Lymphocyte Subsets - immunology - metabolism - radiation effects | - |
dc.title | Differences in Bcl-2 expression by T-cell subsets alter their balance after in vivo irradiation to favor CD4+Bcl-2hi NKT cells | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-2980&volume=39&spage=763&epage=775&date=2009&atitle=Differences+in+Bcl-2+expression+by+T-cell+subsets+alter+their+balance+after+in+vivo+irradiation+to+favor+CD4+Bcl-2hi+NKT+cells. . | en_HK |
dc.identifier.email | Liu, Y: yinpingl@hku.hk | en_HK |
dc.identifier.authority | Liu, Y=rp00269 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1002/eji.200838657 | - |
dc.identifier.pmid | 19197937 | - |
dc.identifier.pmcid | PMC2758339 | - |
dc.identifier.scopus | eid_2-s2.0-64049097681 | - |
dc.identifier.hkuros | 163400 | en_HK |
dc.identifier.volume | 39 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 763 | - |
dc.identifier.epage | 775 | - |
dc.identifier.isi | WOS:000264683500025 | - |
dc.publisher.place | Germany | - |
dc.identifier.issnl | 0014-2980 | - |