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Article: (i) Current understanding of low back pain and intervertebral disc degeneration: epidemiological perspectives and phenotypes for genetic studies

Title(i) Current understanding of low back pain and intervertebral disc degeneration: epidemiological perspectives and phenotypes for genetic studies
Authors
Cheung, KMCAl Ghazi, S
Keywordsannulus fibrosis
degenerative disc disease
genetics
Low back pain
nucleus pulposus
Issue Date2008
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/cuor
Citation
Current Orthopaedics, 2008, v. 22 n. 4, p. 237-244 How to Cite?
DOI: http://dx.doi.org/10.1016/j.cuor.2008.05.004
AbstractLow back pain is now considered more an illness syndrome, rather than a distinct disease. There are many causes of back pain from simple sprain, to complex anatomical derangements to psychosocial issues. Lumbar disc degeneration is one of the more common causes of pathological low back pain. In recent years, there has been a dramatic shift in the understanding of the aetiology of back pain, from an environmental and mechanically based model, to one of a polygenic genetic disorder. This review will summarise the current knowledge on low back pain, and present the latest evidence that this is a genetic disorder. © 2008 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/59451
ISSN
0268-0890
ISI Accession Number ID
WOS:000260098200001
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorAl Ghazi, Sen_HK
dc.date.accessioned2010-05-31T03:50:30Z-
dc.date.available2010-05-31T03:50:30Z-
dc.date.issued2008en_HK
dc.identifier.citationCurrent Orthopaedics, 2008, v. 22 n. 4, p. 237-244en_HK
dc.identifier.issn0268-0890en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59451-
dc.description.abstractLow back pain is now considered more an illness syndrome, rather than a distinct disease. There are many causes of back pain from simple sprain, to complex anatomical derangements to psychosocial issues. Lumbar disc degeneration is one of the more common causes of pathological low back pain. In recent years, there has been a dramatic shift in the understanding of the aetiology of back pain, from an environmental and mechanically based model, to one of a polygenic genetic disorder. This review will summarise the current knowledge on low back pain, and present the latest evidence that this is a genetic disorder. © 2008 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/cuoren_HK
dc.relation.ispartofCurrent Orthopaedicsen_HK
dc.subjectannulus fibrosisen_HK
dc.subjectdegenerative disc diseaseen_HK
dc.subjectgeneticsen_HK
dc.subjectLow back painen_HK
dc.subjectnucleus pulposusen_HK
dc.title(i) Current understanding of low back pain and intervertebral disc degeneration: epidemiological perspectives and phenotypes for genetic studiesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-0890&volume=22&issue=4&spage=237&epage=244&date=2008&atitle=Current+understanding+of+low+back+pain+and+intervertebral+disc+degeneration:+epidemiological+perspectives+and+phenotypes+for+genetic+studiesen_HK
dc.identifier.emailCheung, KMC:cheungmc@hku.hken_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.cuor.2008.05.004en_HK
dc.identifier.scopuseid_2-s2.0-51249121118en_HK
dc.identifier.hkuros165879en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-51249121118&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue4en_HK
dc.identifier.spage237en_HK
dc.identifier.epage244en_HK
dc.identifier.isiWOS:000260098200001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridAl Ghazi, S=24490723100en_HK
dc.identifier.issnl0268-0890-

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