Optimum size of a molecular bond cluster in adhesion

Abstract

The strength of a bonded interface is considered for the case in which bonding is the result of clusters of discrete bonds distributed along the interface. Assumptions appropriate for the case of adhesion of biological cells to an extracellular matrix are introduced as a basis for the discussion. It is observed that those individual bonds nearest to the edges of a cluster are necessarily subjected to disproportionately large forces in transmitting loads across the interface, in analogy with well-known behavior in elastic crack mechanics. Adopting Bell's model for the kinetics of bond response under force, a stochastic model leading to a dependence of interface strength on cluster size is developed and analyzed. On the basis of this model, it is demonstrated that there is an optimum cluster size for maximum strength. This size arises from the competition between the nonuniform force distribution among bonds, which tends to promote smaller clusters, and stochastic response allowing bond reformation, which tends to promote larger clusters. The model results have been confirmed by means of direct Monte Carlo simulations. This analysis may be relevant to the observation that mature focal adhesion zones in cell bonding are found to have a relatively uniform size. © 2008 The American Physical Society.