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- PMID: 19466715
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Article: MR study of postnatal development of myocardial structure and left ventricular function
Title | MR study of postnatal development of myocardial structure and left ventricular function | ||||
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Authors | |||||
Keywords | Cardiac function DTI Heart Myocardium structure Postnatal heart development Rat | ||||
Issue Date | 2009 | ||||
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/ | ||||
Citation | Journal Of Magnetic Resonance Imaging, 2009, v. 30 n. 1, p. 47-53 How to Cite? | ||||
Abstract | Purpose: To investigate postnatal development of left ventricular (LV) cardiac function and myocardium structure. Materials and Methods: In vivo cardiac MR and ex vivo diffusion tensor imaging (DTI) were performed in normal Sprague-Dawley rats at postnatal day 2, 4, 7, 14, 21, 28, and 56 (N = 6 per group). Results: Morphologically, LV size increased with age. Functionally, stroke volume and cardiac output increased. Heart rate increased gradually and became stable after day 14. On average, ejection fraction increased within the first 4 days, decreased at day 7, gradually increased until day 21, and became stable afterward. Structurally, double-helical myocardial structure was found as early as day 2. Myocardial fiber parameters, described by fractional anisotropy, mean apparent diffusion coefficient, and axial diffusivity, increased within the first 4 days. Then radial diffusivity increased until day 7 while other parameters decreased up to day 56. Conclusion: Postnatal heart development was documented by MRI. DTI findings are in agreement with the two known stages of early postnatal growth: hyperplasia and hypertrophy. These results can serve as the baselines for study of postnatal heart developmental abnormalities. They also demonstrate the ability of DTI to reveal microstructural alterations in myocardium. © 2009 Wiley-Liss, Inc. | ||||
Persistent Identifier | http://hdl.handle.net/10722/58733 | ||||
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 1.339 | ||||
ISI Accession Number ID |
Funding Information: Contract grant sponsor: Hong Kong Research Grant Council: Contract grant number: GRF HKU 7794/07M. | ||||
References |
DC Field | Value | Language |
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dc.contributor.author | Wu, Y | en_HK |
dc.contributor.author | Wu, EX | en_HK |
dc.date.accessioned | 2010-05-31T03:35:57Z | - |
dc.date.available | 2010-05-31T03:35:57Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | Journal Of Magnetic Resonance Imaging, 2009, v. 30 n. 1, p. 47-53 | en_HK |
dc.identifier.issn | 1053-1807 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/58733 | - |
dc.description.abstract | Purpose: To investigate postnatal development of left ventricular (LV) cardiac function and myocardium structure. Materials and Methods: In vivo cardiac MR and ex vivo diffusion tensor imaging (DTI) were performed in normal Sprague-Dawley rats at postnatal day 2, 4, 7, 14, 21, 28, and 56 (N = 6 per group). Results: Morphologically, LV size increased with age. Functionally, stroke volume and cardiac output increased. Heart rate increased gradually and became stable after day 14. On average, ejection fraction increased within the first 4 days, decreased at day 7, gradually increased until day 21, and became stable afterward. Structurally, double-helical myocardial structure was found as early as day 2. Myocardial fiber parameters, described by fractional anisotropy, mean apparent diffusion coefficient, and axial diffusivity, increased within the first 4 days. Then radial diffusivity increased until day 7 while other parameters decreased up to day 56. Conclusion: Postnatal heart development was documented by MRI. DTI findings are in agreement with the two known stages of early postnatal growth: hyperplasia and hypertrophy. These results can serve as the baselines for study of postnatal heart developmental abnormalities. They also demonstrate the ability of DTI to reveal microstructural alterations in myocardium. © 2009 Wiley-Liss, Inc. | en_HK |
dc.language | eng | en_HK |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/ | en_HK |
dc.relation.ispartof | Journal of Magnetic Resonance Imaging | en_HK |
dc.subject | Cardiac function | - |
dc.subject | DTI | - |
dc.subject | Heart | - |
dc.subject | Myocardium structure | - |
dc.subject | Postnatal heart development | - |
dc.subject | Rat | - |
dc.subject.mesh | Age Factors | en_HK |
dc.subject.mesh | Analysis of Variance | en_HK |
dc.subject.mesh | Animals | en_HK |
dc.subject.mesh | Animals, Newborn | en_HK |
dc.subject.mesh | Anisotropy | en_HK |
dc.subject.mesh | Cardiac Output - physiology | en_HK |
dc.subject.mesh | Diffusion | en_HK |
dc.subject.mesh | Diffusion Magnetic Resonance Imaging - methods | en_HK |
dc.subject.mesh | Heart - anatomy & histology - growth & development - physiology | en_HK |
dc.subject.mesh | Heart Rate - physiology | en_HK |
dc.subject.mesh | Heart Ventricles - anatomy & histology | en_HK |
dc.subject.mesh | Image Processing, Computer-Assisted - methods | en_HK |
dc.subject.mesh | Magnetic Resonance Imaging - methods | en_HK |
dc.subject.mesh | Rats | en_HK |
dc.subject.mesh | Rats, Sprague-Dawley | en_HK |
dc.subject.mesh | Stroke Volume - physiology | en_HK |
dc.subject.mesh | Ventricular Function, Left - physiology | en_HK |
dc.title | MR study of postnatal development of myocardial structure and left ventricular function | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Wu, EX:ewu1@hkucc.hku.hk | en_HK |
dc.identifier.authority | Wu, EX=rp00193 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1002/jmri.21814 | en_HK |
dc.identifier.pmid | 19466715 | - |
dc.identifier.scopus | eid_2-s2.0-67650067324 | en_HK |
dc.identifier.hkuros | 161960 | en_HK |
dc.identifier.hkuros | 178256 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-67650067324&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 30 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 47 | en_HK |
dc.identifier.epage | 53 | en_HK |
dc.identifier.isi | WOS:000267452600007 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Wu, Y=8940205500 | en_HK |
dc.identifier.scopusauthorid | Wu, EX=7202128034 | en_HK |
dc.identifier.issnl | 1053-1807 | - |