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- Publisher Website: 10.1016/j.neulet.2007.07.031
- Scopus: eid_2-s2.0-34548621284
- PMID: 17728064
- WOS: WOS:000250192500003
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Article: E2F1 is not essential for apoptosis induced by potassium deprivation in cerebellar granule neurons
Title | E2F1 is not essential for apoptosis induced by potassium deprivation in cerebellar granule neurons |
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Authors | |
Keywords | Apoptosis Cerebellar granule neurons E2F1 |
Issue Date | 2007 |
Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet |
Citation | Neuroscience Letters, 2007, v. 424 n. 3, p. 155-159 How to Cite? |
Abstract | Cerebellar granule neurons (CGNs) undergo apoptosis when deprived of depolarizing concentration of potassium. A key regulator of cell cycle, E2F1, was believed to play a role in CGN apoptosis induced by potassium deprivation. However, here we demonstrated that although E2F1 was upregulated in wild type CGNs following potassium deprivation, CGNs that derived from E2F1 knockout mice underwent apoptosis at a similar rate as the wild type. Analysis of the apoptotic neurons revealed no difference in the activation of caspase-3 in E2F1 null and wild type CGNs. Furthermore, knockdown of E2F1 expression by RNA interference failed to attenuate the apoptosis of CGNs induced by potassium deprivation. Taken together, our results suggested that E2F1 is not essential for apoptosis induced by potassium deprivation in CGNs. © 2007 Elsevier Ireland Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/58224 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.745 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yuan, Z | en_HK |
dc.contributor.author | Mei, Y | en_HK |
dc.contributor.author | Zhou, J | en_HK |
dc.contributor.author | Tan, M | en_HK |
dc.contributor.author | Song, B | en_HK |
dc.contributor.author | Ma, C | en_HK |
dc.contributor.author | Ying, C | en_HK |
dc.contributor.author | Li, D | en_HK |
dc.contributor.author | Ching, YP | en_HK |
dc.contributor.author | Li, M | en_HK |
dc.date.accessioned | 2010-05-31T03:26:08Z | - |
dc.date.available | 2010-05-31T03:26:08Z | - |
dc.date.issued | 2007 | en_HK |
dc.identifier.citation | Neuroscience Letters, 2007, v. 424 n. 3, p. 155-159 | en_HK |
dc.identifier.issn | 0304-3940 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/58224 | - |
dc.description.abstract | Cerebellar granule neurons (CGNs) undergo apoptosis when deprived of depolarizing concentration of potassium. A key regulator of cell cycle, E2F1, was believed to play a role in CGN apoptosis induced by potassium deprivation. However, here we demonstrated that although E2F1 was upregulated in wild type CGNs following potassium deprivation, CGNs that derived from E2F1 knockout mice underwent apoptosis at a similar rate as the wild type. Analysis of the apoptotic neurons revealed no difference in the activation of caspase-3 in E2F1 null and wild type CGNs. Furthermore, knockdown of E2F1 expression by RNA interference failed to attenuate the apoptosis of CGNs induced by potassium deprivation. Taken together, our results suggested that E2F1 is not essential for apoptosis induced by potassium deprivation in CGNs. © 2007 Elsevier Ireland Ltd. All rights reserved. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet | en_HK |
dc.relation.ispartof | Neuroscience Letters | en_HK |
dc.subject | Apoptosis | - |
dc.subject | Cerebellar granule neurons | - |
dc.subject | E2F1 | - |
dc.subject.mesh | Animals | en_HK |
dc.subject.mesh | Animals, Newborn | en_HK |
dc.subject.mesh | Apoptosis - drug effects - genetics - physiology | en_HK |
dc.subject.mesh | Cell Count - methods | en_HK |
dc.subject.mesh | Cells, Cultured | en_HK |
dc.subject.mesh | Cerebellum - cytology | en_HK |
dc.subject.mesh | Dose-Response Relationship, Drug | en_HK |
dc.subject.mesh | E2F1 Transcription Factor - deficiency - physiology | en_HK |
dc.subject.mesh | Gene Expression Regulation - drug effects - physiology | en_HK |
dc.subject.mesh | Mice | en_HK |
dc.subject.mesh | Mice, Knockout | en_HK |
dc.subject.mesh | Neurons - drug effects - physiology | en_HK |
dc.subject.mesh | Potassium - pharmacology | en_HK |
dc.subject.mesh | RNA Interference - physiology | en_HK |
dc.subject.mesh | Time Factors | en_HK |
dc.title | E2F1 is not essential for apoptosis induced by potassium deprivation in cerebellar granule neurons | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Ching, YP:ypching@hku.hk | en_HK |
dc.identifier.authority | Ching, YP=rp00469 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.neulet.2007.07.031 | en_HK |
dc.identifier.pmid | 17728064 | - |
dc.identifier.scopus | eid_2-s2.0-34548621284 | en_HK |
dc.identifier.hkuros | 143729 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-34548621284&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 424 | en_HK |
dc.identifier.issue | 3 | en_HK |
dc.identifier.spage | 155 | en_HK |
dc.identifier.epage | 159 | en_HK |
dc.identifier.isi | WOS:000250192500003 | - |
dc.publisher.place | Ireland | en_HK |
dc.identifier.scopusauthorid | Yuan, Z=7401476600 | en_HK |
dc.identifier.scopusauthorid | Mei, Y=7102674721 | en_HK |
dc.identifier.scopusauthorid | Zhou, J=7405545445 | en_HK |
dc.identifier.scopusauthorid | Tan, M=21740168400 | en_HK |
dc.identifier.scopusauthorid | Song, B=35234938900 | en_HK |
dc.identifier.scopusauthorid | Ma, C=35080792100 | en_HK |
dc.identifier.scopusauthorid | Ying, C=21740028600 | en_HK |
dc.identifier.scopusauthorid | Li, D=26324923700 | en_HK |
dc.identifier.scopusauthorid | Ching, YP=7005431277 | en_HK |
dc.identifier.scopusauthorid | Li, M=12765700400 | en_HK |
dc.identifier.issnl | 0304-3940 | - |