File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)

Article: Intracerebroventricular infusion of cytosine-arabinoside causes prepulse inhibition disruption

TitleIntracerebroventricular infusion of cytosine-arabinoside causes prepulse inhibition disruption
Authors
KeywordsHippocampus
Neurogenesis
Prepulse inhibition disruption
Propulse inhibition
Sensorimotor gating
Subventricular zone
Issue Date2009
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.com
Citation
Neuroreport, 2009, v. 20 n. 4, p. 371-377 How to Cite?
AbstractAdult neurogenesjs in hippocampus is associated with behaviors such as learning. Hippocampus is involved in the regulation of prepulse inhibition (PPI), but the relationship between neurogenesis and PPI is unexplored. We conducted four experiments to determine the role of neural progenitor cell proliferation in PPI. Intracerebroventricular infusion of cytostatic cytosine arabinoside caused PPI disruption but repeated exposure to PPI sessions prevented the PPI disruption. Corticosterone treatment, which decreases hippocampal cell proliferation, caused PPI disruption, whereas antidepressant and exercise, which increased cell proliferation, did not affect PPI. These results suggest that cell proliferation is involved in the first encounter with PPI test while its importance may decrease upon repeated exposures to the tests. © 2009 Wolters Kluwer Health|Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/58188
ISSN
2023 Impact Factor: 1.6
2023 SCImago Journal Rankings: 0.459
ISI Accession Number ID
Funding AgencyGrant Number
Jessie Ho Professorship in Neuroscience (The University of Hong Kong Foundation for Educational Development and Research Limited)
Funding Information:

This study was supported by funding from the Jessie Ho Professorship in Neuroscience (The University of Hong Kong Foundation for Educational Development and Research Limited).

References

 

DC FieldValueLanguage
dc.contributor.authorLau, BWMen_HK
dc.contributor.authorYau, SYen_HK
dc.contributor.authorLee, TMCen_HK
dc.contributor.authorChing, YPen_HK
dc.contributor.authorTang, SWen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2010-05-31T03:25:28Z-
dc.date.available2010-05-31T03:25:28Z-
dc.date.issued2009en_HK
dc.identifier.citationNeuroreport, 2009, v. 20 n. 4, p. 371-377en_HK
dc.identifier.issn0959-4965en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58188-
dc.description.abstractAdult neurogenesjs in hippocampus is associated with behaviors such as learning. Hippocampus is involved in the regulation of prepulse inhibition (PPI), but the relationship between neurogenesis and PPI is unexplored. We conducted four experiments to determine the role of neural progenitor cell proliferation in PPI. Intracerebroventricular infusion of cytostatic cytosine arabinoside caused PPI disruption but repeated exposure to PPI sessions prevented the PPI disruption. Corticosterone treatment, which decreases hippocampal cell proliferation, caused PPI disruption, whereas antidepressant and exercise, which increased cell proliferation, did not affect PPI. These results suggest that cell proliferation is involved in the first encounter with PPI test while its importance may decrease upon repeated exposures to the tests. © 2009 Wolters Kluwer Health|Lippincott Williams & Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.comen_HK
dc.relation.ispartofNeuroReporten_HK
dc.rightsNeuroreport. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subjectHippocampus-
dc.subjectNeurogenesis-
dc.subjectPrepulse inhibition disruption-
dc.subjectPropulse inhibition-
dc.subjectSensorimotor gating-
dc.subjectSubventricular zone-
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAntidepressive Agents - pharmacologyen_HK
dc.subject.meshBromodeoxyuridine - metabolismen_HK
dc.subject.meshCorticosterone - pharmacologyen_HK
dc.subject.meshCytarabine - administration & dosage - pharmacologyen_HK
dc.subject.meshHippocampus - cytology - drug effects - physiologyen_HK
dc.subject.meshInjections, Intraventricularen_HK
dc.subject.meshMaleen_HK
dc.subject.meshNeural Inhibition - drug effectsen_HK
dc.subject.meshNeurogenesis - drug effectsen_HK
dc.subject.meshParoxetine - pharmacologyen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshStartle Reaction - drug effectsen_HK
dc.titleIntracerebroventricular infusion of cytosine-arabinoside causes prepulse inhibition disruptionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0959-4965&volume=20&spage=371&epage=377&date=2009&atitle=Intracerebroventricular+infusion+of+cytosine-arabinoside+causes+prepulse+inhibition+disruption.+en_HK
dc.identifier.emailLee, TMC:tmclee@hku.hken_HK
dc.identifier.emailChing, YP:ypching@hku.hken_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityLee, TMC=rp00564en_HK
dc.identifier.authorityChing, YP=rp00469en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/WNR.0b013e328324edcden_HK
dc.identifier.pmid19218868en_HK
dc.identifier.scopuseid_2-s2.0-62449143786en_HK
dc.identifier.hkuros158104en_HK
dc.identifier.hkuros160612-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-62449143786&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue4en_HK
dc.identifier.spage371en_HK
dc.identifier.epage377en_HK
dc.identifier.isiWOS:000264516700005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLau, BWM=21934562200en_HK
dc.identifier.scopusauthoridYau, SY=24330296200en_HK
dc.identifier.scopusauthoridLee, TMC=7501437381en_HK
dc.identifier.scopusauthoridChing, YP=7005431277en_HK
dc.identifier.scopusauthoridTang, SW=23968420300en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.issnl0959-4965-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats