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Article: Solubility of strontium-substituted apatite by solid titration

TitleSolubility of strontium-substituted apatite by solid titration
Authors
Pan, HBLi, ZYLam, WMWong, JCDarvell, BWLuk, KDKLu, WW
KeywordsHydroxyapatite
Solid titration
Solubility
Strontium-substituted apatite
Issue Date2009
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat
Citation
Acta Biomaterialia, 2009, v. 5 n. 5, p. 1678-1685 How to Cite?
DOI: http://dx.doi.org/10.1016/j.actbio.2008.11.032
AbstractSolid titration was used to explore the solubility isotherms of partially (Srx-HAp, x = 1, 5, 10, 40, 60 mol.%) and fully substituted strontium hydroxyapatite (Sr-HAp). Solubility increased with increasing strontium content. No phase other than strontium-substituted HAp, corresponding to the original titrant, was detected in the solid present at equilibrium; in particular, dicalcium hydrogen phosphate was not detected at low pH. The increase in solubility with strontium content is interpreted as a destabilization of the crystal structure by the larger strontium ion. Carbonated HAp was formed in simulated body fluid containing carbonate on seeding with Sr10-HAp, but the precipitate was strontium-substituted on seeding with Sr-HAp. Strontium-substituted HAp might be usable as a template for the growth of new bone, since nucleation appears to be facilitated. © 2008 Acta Materialia Inc.
Persistent Identifierhttp://hdl.handle.net/10722/58026
ISSN
1742-7061
2023 Impact Factor: 9.4
2023 SCImago Journal Rankings: 1.925
ISI Accession Number ID
WOS:000266506800031
Funding AgencyGrant Number
Hong Kong ITFGHP/009/06
HKRGCHKU7147/07E
Funding Information:

This study was supported by Hong Kong ITF GHP/009/06 and HKRGC (HKU7147/07E). The authors thank Frankie Chan for his assistance in TEM analysis and Guofeng Chen for XRD analysis.

References
References in Scopus
Grants
Optimization and commercialization of strontium containing bioactive bone cement for various orthopaedic applications

 

DC FieldValueLanguage
dc.contributor.authorPan, HBen_HK
dc.contributor.authorLi, ZYen_HK
dc.contributor.authorLam, WMen_HK
dc.contributor.authorWong, JCen_HK
dc.contributor.authorDarvell, BWen_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorLu, WWen_HK
dc.date.accessioned2010-05-31T03:22:34Z-
dc.date.available2010-05-31T03:22:34Z-
dc.date.issued2009en_HK
dc.identifier.citationActa Biomaterialia, 2009, v. 5 n. 5, p. 1678-1685en_HK
dc.identifier.issn1742-7061en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58026-
dc.description.abstractSolid titration was used to explore the solubility isotherms of partially (Srx-HAp, x = 1, 5, 10, 40, 60 mol.%) and fully substituted strontium hydroxyapatite (Sr-HAp). Solubility increased with increasing strontium content. No phase other than strontium-substituted HAp, corresponding to the original titrant, was detected in the solid present at equilibrium; in particular, dicalcium hydrogen phosphate was not detected at low pH. The increase in solubility with strontium content is interpreted as a destabilization of the crystal structure by the larger strontium ion. Carbonated HAp was formed in simulated body fluid containing carbonate on seeding with Sr10-HAp, but the precipitate was strontium-substituted on seeding with Sr-HAp. Strontium-substituted HAp might be usable as a template for the growth of new bone, since nucleation appears to be facilitated. © 2008 Acta Materialia Inc.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomaten_HK
dc.relation.ispartofActa Biomaterialiaen_HK
dc.rightsActa Biomaterialia. Copyright © Elsevier BV.en_HK
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectHydroxyapatiteen_HK
dc.subjectSolid titrationen_HK
dc.subjectSolubilityen_HK
dc.subjectStrontium-substituted apatiteen_HK
dc.subject.meshBody Fluids-
dc.subject.meshCalcium - chemistry-
dc.subject.meshHydroxyapatites - chemistry-
dc.subject.meshStrontium - chemistry-
dc.subject.meshTitrimetry - methods-
dc.titleSolubility of strontium-substituted apatite by solid titrationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1742-7061&volume=5&issue=5&spage=1678&epage=1685&date=2009&atitle=Solubility+of+strontium-substituted+apatite+by+solid+titrationen_HK
dc.identifier.emailPan, HB: haobo@hku.hken_HK
dc.identifier.emailDarvell, BW: b.w.darvell@hku.hken_HK
dc.identifier.emailLuk, KDK: hcm21000@hku.hken_HK
dc.identifier.emailLu, WW: wwlu@hku.hken_HK
dc.identifier.authorityPan, HB=rp01564en_HK
dc.identifier.authorityDarvell, BW=rp00007en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.actbio.2008.11.032en_HK
dc.identifier.pmid19135423-
dc.identifier.scopuseid_2-s2.0-67349159702en_HK
dc.identifier.hkuros163518en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67349159702&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1678en_HK
dc.identifier.epage1685en_HK
dc.identifier.eissn1878-7568-
dc.identifier.isiWOS:000266506800031-
dc.publisher.placeNetherlandsen_HK
dc.relation.projectOptimization and commercialization of strontium containing bioactive bone cement for various orthopaedic applications-
dc.identifier.scopusauthoridPan, HB=7403295092en_HK
dc.identifier.scopusauthoridLi, ZY=35784563200en_HK
dc.identifier.scopusauthoridLam, WM=13403256300en_HK
dc.identifier.scopusauthoridWong, JC=35207628900en_HK
dc.identifier.scopusauthoridDarvell, BW=7005953926en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.issnl1742-7061-

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