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- Scopus: eid_2-s2.0-23444453486
- PMID: 8183572
- WOS: WOS:A1994NL81500029
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Article: MLK-3: Identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain
Title | MLK-3: Identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain |
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Authors | |
Issue Date | 1994 |
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/onc |
Citation | Oncogene, 1994, v. 9 n. 6, p. 1745-1750 How to Cite? |
Abstract | We have identified a novel protein kinase, designated MLK-3, from human thymus using RT-PCR and cDNA library screening. The deduced open reading frame, derived from sequencing a 3.5 kb MLK-3 cDNA, encodes a protein of 847 amino acids with several interesting structural features. These include an SH3 domain in the absence of an SH2 domain, a region containing two leucine zippers with an adjacent carboxy-terminal basic region, and a proline rich region. This kinase shows homology with the mixed-lineage family of protein kinases (MLK) and shares the unusual leucine zipper-basic motif found in previously identified MLK kinases. By northern analysis, MLK-3 mRNA was detected in a wide variety of normal and transformed human cell lines and tissue specimens. The gene encoding MLK-3 has been mapped using fluorescence in situ hybridization to human chromosome 11 q13.1-13.3, a region frequently altered in human malignancies. |
Persistent Identifier | http://hdl.handle.net/10722/44280 |
ISSN | 2023 Impact Factor: 6.9 2023 SCImago Journal Rankings: 2.334 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lynn Ing, Y | en_HK |
dc.contributor.author | Leung, IWL | en_HK |
dc.contributor.author | Heng, HHQ | en_HK |
dc.contributor.author | Tsui, LC | en_HK |
dc.contributor.author | Lassam, NJ | en_HK |
dc.date.accessioned | 2007-09-12T03:50:32Z | - |
dc.date.available | 2007-09-12T03:50:32Z | - |
dc.date.issued | 1994 | en_HK |
dc.identifier.citation | Oncogene, 1994, v. 9 n. 6, p. 1745-1750 | en_HK |
dc.identifier.issn | 0950-9232 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/44280 | - |
dc.description.abstract | We have identified a novel protein kinase, designated MLK-3, from human thymus using RT-PCR and cDNA library screening. The deduced open reading frame, derived from sequencing a 3.5 kb MLK-3 cDNA, encodes a protein of 847 amino acids with several interesting structural features. These include an SH3 domain in the absence of an SH2 domain, a region containing two leucine zippers with an adjacent carboxy-terminal basic region, and a proline rich region. This kinase shows homology with the mixed-lineage family of protein kinases (MLK) and shares the unusual leucine zipper-basic motif found in previously identified MLK kinases. By northern analysis, MLK-3 mRNA was detected in a wide variety of normal and transformed human cell lines and tissue specimens. The gene encoding MLK-3 has been mapped using fluorescence in situ hybridization to human chromosome 11 q13.1-13.3, a region frequently altered in human malignancies. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/onc | en_HK |
dc.relation.ispartof | Oncogene | en_HK |
dc.subject.mesh | Leucine zippers | en_HK |
dc.subject.mesh | Protein kinases - chemistry - genetics | en_HK |
dc.subject.mesh | Rna, messenger - analysis | en_HK |
dc.subject.mesh | Chromosomes, human, pair 11 | en_HK |
dc.subject.mesh | Molecular sequence data | en_HK |
dc.title | MLK-3: Identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Tsui, LC: tsuilc@hkucc.hku.hk | en_HK |
dc.identifier.authority | Tsui, LC=rp00058 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_HK |
dc.identifier.pmid | 8183572 | en_HK |
dc.identifier.scopus | eid_2-s2.0-23444453486 | en_HK |
dc.identifier.volume | 9 | en_HK |
dc.identifier.issue | 6 | en_HK |
dc.identifier.spage | 1745 | en_HK |
dc.identifier.epage | 1750 | en_HK |
dc.identifier.isi | WOS:A1994NL81500029 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Lynn Ing, Y=6701750065 | en_HK |
dc.identifier.scopusauthorid | Leung, IWL=36913978400 | en_HK |
dc.identifier.scopusauthorid | Heng, HHQ=7005338076 | en_HK |
dc.identifier.scopusauthorid | Tsui, LC=7102754167 | en_HK |
dc.identifier.scopusauthorid | Lassam, NJ=7003743180 | en_HK |
dc.identifier.issnl | 0950-9232 | - |