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Article: Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome

TitleGenes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome
Authors
Heng, HHQXiao, HShi, XMGreenblatt, JTsui, LC
Issue Date1994
PublisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
Citation
Human Molecular Genetics, 1994, v. 3 n. 1, p. 61-64 How to Cite?
DOI: http://dx.doi.org/10.1093/hmg/3.1.61
AbstractGeneral transcription factors are required for accurate initiation of transcription by RNA polymerase II. Human cDNAs encoding subunits of these factors have been cloned and sequenced. Using fluorescence in situ hybridization (FISH), we show here that the genes encoding the TATA-box binding protein (TBP), TFIIB, TFIIEα, TFIIEβ, RAP30, RAP74 and the 62 kDa subunit of TFIIH are located at the human chromosomal bands 6q26-27, 1p21-22, 3q21-24, 8pl2, 13q14, l9p13.3 and 11 p14 -15.1, respectively. This dispersed localization of a group of functionally related gene provides insights into the molecular mechanism of human genome evolution and their possible involvement in human diseases.
Persistent Identifierhttp://hdl.handle.net/10722/44271
ISSN
0964-6906
2023 Impact Factor: 3.1
2023 SCImago Journal Rankings: 1.602
ISI Accession Number ID
WOS:A1994MU61700012

 

DC FieldValueLanguage
dc.contributor.authorHeng, HHQen_HK
dc.contributor.authorXiao, Hen_HK
dc.contributor.authorShi, XMen_HK
dc.contributor.authorGreenblatt, Jen_HK
dc.contributor.authorTsui, LCen_HK
dc.date.accessioned2007-09-12T03:50:21Z-
dc.date.available2007-09-12T03:50:21Z-
dc.date.issued1994en_HK
dc.identifier.citationHuman Molecular Genetics, 1994, v. 3 n. 1, p. 61-64en_HK
dc.identifier.issn0964-6906en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44271-
dc.description.abstractGeneral transcription factors are required for accurate initiation of transcription by RNA polymerase II. Human cDNAs encoding subunits of these factors have been cloned and sequenced. Using fluorescence in situ hybridization (FISH), we show here that the genes encoding the TATA-box binding protein (TBP), TFIIB, TFIIEα, TFIIEβ, RAP30, RAP74 and the 62 kDa subunit of TFIIH are located at the human chromosomal bands 6q26-27, 1p21-22, 3q21-24, 8pl2, 13q14, l9p13.3 and 11 p14 -15.1, respectively. This dispersed localization of a group of functionally related gene provides insights into the molecular mechanism of human genome evolution and their possible involvement in human diseases.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/en_HK
dc.relation.ispartofHuman Molecular Geneticsen_HK
dc.subject.meshChromosomes, humanen_HK
dc.subject.meshGenome, humanen_HK
dc.subject.meshTranscription factors, tfiien_HK
dc.subject.meshTranscription factors - geneticsen_HK
dc.subject.meshRna polymerase ii - metabolismen_HK
dc.titleGenes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genomeen_HK
dc.typeArticleen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1093/hmg/3.1.61-
dc.identifier.pmid8162052-
dc.identifier.scopuseid_2-s2.0-0028098186en_HK
dc.identifier.volume3en_HK
dc.identifier.issue1en_HK
dc.identifier.spage61en_HK
dc.identifier.epage64en_HK
dc.identifier.isiWOS:A1994MU61700012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHeng, HHQ=7005338076en_HK
dc.identifier.scopusauthoridXiao, H=7401564754en_HK
dc.identifier.scopusauthoridShi, XM=7402953863en_HK
dc.identifier.scopusauthoridGreenblatt, J=7005082559en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.issnl0964-6906-

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