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Article: A cluster of cases of severe acute respiratory syndrome in Hong Kong
Title | A cluster of cases of severe acute respiratory syndrome in Hong Kong |
---|---|
Authors | |
Issue Date | 2003 |
Publisher | Massachusetts Medical Society. The Journal's web site is located at http://content.nejm.org/ |
Citation | New England Journal of Medicine, 2003, v. 348 n. 20, p. 1977-1985 How to Cite? |
Abstract | BACKGROUND: Information on the clinical features of the severe acute respiratory syndrome (SARS) will be of value to physicians caring for patients suspected of having this disorder. METHODS: We abstracted data on the clinical presentation and course of disease in 10 epidemiologically linked Chinese patients (5 men and 5 women 38 to 72 years old) in whom SARS was diagnosed between February 22, 2003, and March 22, 2003, at our hospitals in Hong Kong, China. RESULTS: Exposure between the source patient and subsequent patients ranged from minimal to that between patient and health care provider. The incubation period ranged from 2 to 11 days. All patients presented with fever (temperature, >38°C for over 24 hours), and most presented with rigor, dry cough, dyspnea, malaise, headache, and hypoxemia. Physical examination of the chest revealed crackles and percussion dullness. Lymphopenia was observed in nine patients, and most patients had mildly elevated aminotransferase levels but normal serum creatinine levels. Serial chest radiographs showed progressive air-space disease. Two patients died of progressive respiratory failure; histologic analysis of their lungs showed diffuse alveolar damage. There was no evidence of infection by Mycoplasma pneumoniae, Chlamydia pneumoniae, or Legionella pneumophila. All patients received corticosteroid and ribavirin therapy a mean (±SD) of 9.6±5.42 days after the onset of symptoms, and eight were treated earlier with a combination of beta-lactams and macrolide for 4±1.9 days, with no clinical or radiologic efficacy. CONCLUSIONS: SARS appears to be infectious in origin. Fever followed by rapidly progressive respiratory compromise is the key complex of signs and symptoms from which the syndrome derives its name. The microbiologic origins of SARS remain unclear. |
Persistent Identifier | http://hdl.handle.net/10722/43134 |
ISSN | 2023 Impact Factor: 96.2 2023 SCImago Journal Rankings: 20.544 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tsang, KW | en_HK |
dc.contributor.author | Ho, PL | en_HK |
dc.contributor.author | Ooi, GC | en_HK |
dc.contributor.author | Yee, WK | en_HK |
dc.contributor.author | Wang, T | en_HK |
dc.contributor.author | ChanYeung, M | en_HK |
dc.contributor.author | Lam, WK | en_HK |
dc.contributor.author | Seto, WH | en_HK |
dc.contributor.author | Yam, LY | en_HK |
dc.contributor.author | Cheung, TM | en_HK |
dc.contributor.author | Wong, PC | en_HK |
dc.contributor.author | Lam, B | en_HK |
dc.contributor.author | Ip, MS | en_HK |
dc.contributor.author | Chan, J | en_HK |
dc.contributor.author | Yuen, KY | en_HK |
dc.contributor.author | Lai, KN | en_HK |
dc.date.accessioned | 2007-03-23T04:39:39Z | - |
dc.date.available | 2007-03-23T04:39:39Z | - |
dc.date.issued | 2003 | en_HK |
dc.identifier.citation | New England Journal of Medicine, 2003, v. 348 n. 20, p. 1977-1985 | en_HK |
dc.identifier.issn | 0028-4793 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/43134 | - |
dc.description.abstract | BACKGROUND: Information on the clinical features of the severe acute respiratory syndrome (SARS) will be of value to physicians caring for patients suspected of having this disorder. METHODS: We abstracted data on the clinical presentation and course of disease in 10 epidemiologically linked Chinese patients (5 men and 5 women 38 to 72 years old) in whom SARS was diagnosed between February 22, 2003, and March 22, 2003, at our hospitals in Hong Kong, China. RESULTS: Exposure between the source patient and subsequent patients ranged from minimal to that between patient and health care provider. The incubation period ranged from 2 to 11 days. All patients presented with fever (temperature, >38°C for over 24 hours), and most presented with rigor, dry cough, dyspnea, malaise, headache, and hypoxemia. Physical examination of the chest revealed crackles and percussion dullness. Lymphopenia was observed in nine patients, and most patients had mildly elevated aminotransferase levels but normal serum creatinine levels. Serial chest radiographs showed progressive air-space disease. Two patients died of progressive respiratory failure; histologic analysis of their lungs showed diffuse alveolar damage. There was no evidence of infection by Mycoplasma pneumoniae, Chlamydia pneumoniae, or Legionella pneumophila. All patients received corticosteroid and ribavirin therapy a mean (±SD) of 9.6±5.42 days after the onset of symptoms, and eight were treated earlier with a combination of beta-lactams and macrolide for 4±1.9 days, with no clinical or radiologic efficacy. CONCLUSIONS: SARS appears to be infectious in origin. Fever followed by rapidly progressive respiratory compromise is the key complex of signs and symptoms from which the syndrome derives its name. The microbiologic origins of SARS remain unclear. | en_HK |
dc.format.extent | 139896 bytes | - |
dc.format.extent | 30720 bytes | - |
dc.format.extent | 2800 bytes | - |
dc.format.extent | 2603 bytes | - |
dc.format.extent | 2236 bytes | - |
dc.format.extent | 2450 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.format.mimetype | application/msword | - |
dc.format.mimetype | text/plain | - |
dc.format.mimetype | text/plain | - |
dc.format.mimetype | text/plain | - |
dc.format.mimetype | text/plain | - |
dc.language | eng | en_HK |
dc.publisher | Massachusetts Medical Society. The Journal's web site is located at http://content.nejm.org/ | en_HK |
dc.relation.ispartof | New England Journal of Medicine | en_HK |
dc.rights | From New England Journal of Medicine, Kenneth W. Tsang, Pak L. Ho, Gaik C. Ooi, et al., A cluster of cases of severe acute respiratory syndrome in Hong Kong, vol. 348, p. 1977-1985. Copyright © 2003 Massachusetts Medical Society. Reprinted with permission. | - |
dc.subject.mesh | Disease outbreaks | en_HK |
dc.subject.mesh | Drug therapy, combination | en_HK |
dc.subject.mesh | Hong kong - epidemiology | en_HK |
dc.subject.mesh | Lung - radiography | en_HK |
dc.subject.mesh | Ribavirin - therapeutic use | en_HK |
dc.title | A cluster of cases of severe acute respiratory syndrome in Hong Kong | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Ho, PL: plho@hkucc.hku.hk | en_HK |
dc.identifier.email | Ip, MS: msmip@hku.hk | en_HK |
dc.identifier.email | Yuen, KY: kyyuen@hkucc.hku.hk | en_HK |
dc.identifier.email | Lai, KN: knlai@hku.hk | en_HK |
dc.identifier.authority | Ho, PL=rp00406 | en_HK |
dc.identifier.authority | Ip, MS=rp00347 | en_HK |
dc.identifier.authority | Yuen, KY=rp00366 | en_HK |
dc.identifier.authority | Lai, KN=rp00324 | en_HK |
dc.description.nature | published_or_final_version | en_HK |
dc.identifier.doi | 10.1056/NEJMoa030666 | en_HK |
dc.identifier.pmid | 12671062 | - |
dc.identifier.scopus | eid_2-s2.0-0013255608 | en_HK |
dc.identifier.hkuros | 79043 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0013255608&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 348 | en_HK |
dc.identifier.issue | 20 | en_HK |
dc.identifier.spage | 1977 | en_HK |
dc.identifier.epage | 1985 | en_HK |
dc.identifier.isi | WOS:000182823400006 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Tsang, KW=7201555024 | en_HK |
dc.identifier.scopusauthorid | Ho, PL=7402211363 | en_HK |
dc.identifier.scopusauthorid | Ooi, GC=7006176119 | en_HK |
dc.identifier.scopusauthorid | Yee, WK=7005216073 | en_HK |
dc.identifier.scopusauthorid | Wang, T=7405566621 | en_HK |
dc.identifier.scopusauthorid | ChanYeung, M=54790582200 | en_HK |
dc.identifier.scopusauthorid | Lam, WK=7203021937 | en_HK |
dc.identifier.scopusauthorid | Seto, WH=7005799377 | en_HK |
dc.identifier.scopusauthorid | Yam, LY=7102764741 | en_HK |
dc.identifier.scopusauthorid | Cheung, TM=7103334508 | en_HK |
dc.identifier.scopusauthorid | Wong, PC=7403979916 | en_HK |
dc.identifier.scopusauthorid | Lam, B=9246012800 | en_HK |
dc.identifier.scopusauthorid | Ip, MS=7102423259 | en_HK |
dc.identifier.scopusauthorid | Chan, J=27169797600 | en_HK |
dc.identifier.scopusauthorid | Yuen, KY=36078079100 | en_HK |
dc.identifier.scopusauthorid | Lai, KN=7402135706 | en_HK |
dc.identifier.issnl | 0028-4793 | - |