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Article: Linkage of cystic fibrosis to the proα2(I) collagen gene, COL1A2, on chromosome 7

TitleLinkage of cystic fibrosis to the proα2(I) collagen gene, COL1A2, on chromosome 7
Authors
Buchwald, MZsiga, MMarkiewicz, DPlavsic, NKennedy, DZengerling, SWillard, HFTsipouras, PSchmiegelow, KSchwartz, MEiberg, HMohr, JBarker, DDonis-Keller, HTsui, LC
KeywordsBiology
Genetics biology
Cytology and histology
Issue Date1986
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/CGR
Citation
Cytogenetics and cell genetics, 1986, v. 41 n. 4, p. 234-239 How to Cite?
DOI: http://dx.doi.org/10.1159/000132235
AbstractA linkage has been detected between the locus for cystic fibrosis (CF) and the proα2(I) collagen gene (COL1A2) which is located in the region q21.3→q22.1 of chromosome 7. Based on the combined linkage data derived from 50 informative two-generation nuclear families collected in Canada and Denmark, the distance between COL1A2 and CF is estimated to be 19 centiMorgans. Close lilnkage has also been detected between COL1A2 and the DNA market D7S15 (formerly D0CRI-917) and the serum enzyme activity marker paraoxonase (PON), both of which have previously been found linked to CF. The results of the two-oint and three-point linkage analyses indicate that the most probable order of these four genetic loci is COL1A2-D7S15-PON-CF.
Persistent Identifierhttp://hdl.handle.net/10722/42528
ISSN
0301-0171
ISI Accession Number ID
WOS:A1986C881500007

 

DC FieldValueLanguage
dc.contributor.authorBuchwald, Men_HK
dc.contributor.authorZsiga, Men_HK
dc.contributor.authorMarkiewicz, Den_HK
dc.contributor.authorPlavsic, Nen_HK
dc.contributor.authorKennedy, Den_HK
dc.contributor.authorZengerling, Sen_HK
dc.contributor.authorWillard, HFen_HK
dc.contributor.authorTsipouras, Pen_HK
dc.contributor.authorSchmiegelow, Ken_HK
dc.contributor.authorSchwartz, Men_HK
dc.contributor.authorEiberg, Hen_HK
dc.contributor.authorMohr, Jen_HK
dc.contributor.authorBarker, Den_HK
dc.contributor.authorDonis-Keller, Hen_HK
dc.contributor.authorTsui, LCen_HK
dc.date.accessioned2007-01-29T08:52:14Z-
dc.date.available2007-01-29T08:52:14Z-
dc.date.issued1986en_HK
dc.identifier.citationCytogenetics and cell genetics, 1986, v. 41 n. 4, p. 234-239en_HK
dc.identifier.issn0301-0171en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42528-
dc.description.abstractA linkage has been detected between the locus for cystic fibrosis (CF) and the proα2(I) collagen gene (COL1A2) which is located in the region q21.3→q22.1 of chromosome 7. Based on the combined linkage data derived from 50 informative two-generation nuclear families collected in Canada and Denmark, the distance between COL1A2 and CF is estimated to be 19 centiMorgans. Close lilnkage has also been detected between COL1A2 and the DNA market D7S15 (formerly D0CRI-917) and the serum enzyme activity marker paraoxonase (PON), both of which have previously been found linked to CF. The results of the two-oint and three-point linkage analyses indicate that the most probable order of these four genetic loci is COL1A2-D7S15-PON-CF.en_HK
dc.format.extent942804 bytes-
dc.format.extent25088 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/CGRen_HK
dc.subjectBiologyen_HK
dc.subjectGenetics biologyen_HK
dc.subjectCytology and histologyen_HK
dc.titleLinkage of cystic fibrosis to the proα2(I) collagen gene, COL1A2, on chromosome 7en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0301-0171&volume=41&spage=234&epage=239&date=1986&atitle=Linkage+of+cystic+fibrosis+to+the+proα2(I)+collagen+gene,+COL1A2,+on+chromosome+7en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1159/000132235-
dc.identifier.pmid3011363-
dc.identifier.scopuseid_2-s2.0-0022567668-
dc.identifier.isiWOS:A1986C881500007-
dc.identifier.issnl0301-0171-

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