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Article: Single-Cell RNA Sequencing of hESC-Derived 3D Retinal Organoids Reveals Novel Genes Regulating RPC Commitment in Early Human Retinogenesis

TitleSingle-Cell RNA Sequencing of hESC-Derived 3D Retinal Organoids Reveals Novel Genes Regulating RPC Commitment in Early Human Retinogenesis
Authors
Mao, XiyingAn, QinXi, HuiyuYang, Xian JieZhang, XiangmeiYuan, SongtaoWang, JinmeiHu, YoujinLiu, QinghuaiFan, Guoping
Keywordscommitment
early human retinal development
human embryonic stem cell
retina
retinal progenitor
single-cell RNA-seq
Issue Date2019
Citation
Stem Cell Reports, 2019, v. 13, n. 4, p. 747-760 How to Cite?
DOI: http://dx.doi.org/10.1016/j.stemcr.2019.08.012
AbstractRetinogenesis is a complicated process involving generating distinct types of neurons from retinal progenitor cells (RPCs) in a spatiotemporal-specific manner. By taking the advantage of hESC-derived retinal organoids and single-cell RNA sequencing, Fan, Liu, Hu and colleagues show the genetic program dynamics during RPC progression. Their results revealed critical pathways and novel genes involved in early retinogenesis of humans.
Persistent Identifierhttp://hdl.handle.net/10722/365729
ISSN
2213-6711
2023 Impact Factor: 5.9
2023 SCImago Journal Rankings: 2.518

 

DC FieldValueLanguage
dc.contributor.authorMao, Xiying-
dc.contributor.authorAn, Qin-
dc.contributor.authorXi, Huiyu-
dc.contributor.authorYang, Xian Jie-
dc.contributor.authorZhang, Xiangmei-
dc.contributor.authorYuan, Songtao-
dc.contributor.authorWang, Jinmei-
dc.contributor.authorHu, Youjin-
dc.contributor.authorLiu, Qinghuai-
dc.contributor.authorFan, Guoping-
dc.date.accessioned2025-11-05T09:47:04Z-
dc.date.available2025-11-05T09:47:04Z-
dc.date.issued2019-
dc.identifier.citationStem Cell Reports, 2019, v. 13, n. 4, p. 747-760-
dc.identifier.issn2213-6711-
dc.identifier.urihttp://hdl.handle.net/10722/365729-
dc.description.abstractRetinogenesis is a complicated process involving generating distinct types of neurons from retinal progenitor cells (RPCs) in a spatiotemporal-specific manner. By taking the advantage of hESC-derived retinal organoids and single-cell RNA sequencing, Fan, Liu, Hu and colleagues show the genetic program dynamics during RPC progression. Their results revealed critical pathways and novel genes involved in early retinogenesis of humans.-
dc.languageeng-
dc.relation.ispartofStem Cell Reports-
dc.subjectcommitment-
dc.subjectearly human retinal development-
dc.subjecthuman embryonic stem cell-
dc.subjectretina-
dc.subjectretinal progenitor-
dc.subjectsingle-cell RNA-seq-
dc.titleSingle-Cell RNA Sequencing of hESC-Derived 3D Retinal Organoids Reveals Novel Genes Regulating RPC Commitment in Early Human Retinogenesis-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.stemcr.2019.08.012-
dc.identifier.pmid31543471-
dc.identifier.scopuseid_2-s2.0-85072701828-
dc.identifier.volume13-
dc.identifier.issue4-
dc.identifier.spage747-
dc.identifier.epage760-

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