Impacts of night shift on medical professionals: a pilot study of brain connectivity and gut microbiota

Abstract

Night shift is a prevalent workstyle in medical hospitals, demanding continuous health monitoring and rapid decision making of medical professionals. Night shifts may cause serious health problems to medical staff, including cognitive impairments, poor sleep, and inflammatory responses, leading to the altered gut-brain axis. However, how night shifts impact gut-brain axis and how long the impact lasts remain to be studied. Hence, we investigated the dynamic changes of brain-microbiota relations following night shifts and subsequent recovery days among medical shift workers. Young medical staffs were recruited for the 3-session assessments over the scheduled night shifts (pre-shift, post-shift, and recovery) by measuring (a) sleep metrics, (b) brain functions, (c) gut bacteriome compositions, and (d) cognitive assessments. Participants experienced partial sleep deprivation only during the 5-day night shifts but rapidly returned to baseline after the 4-day recovery, so as the elevated brain fluctuations in the superior frontal gyrus after night shifts. Meanwhile, the night shifts caused elongated connectivity changes of default-mode and dorsal attention networks without recovery. Nevertheless, we did not find prevailing night-shift effects on cognition and gut bacteriome compositions, except the Gemellaceae concentration and the multi-task performance. Collectively, night shifts may induce prolonged alterations on brain connectivity without impacts on gut bacteriome, suggesting the vulnerable brain functions and the resilient gut bacteriome to the short-term night shifts among medical shift workers.