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Conference Paper: Exploring Salivary Profiles in Relation to Dental Caries and Obesity
| Title | Exploring Salivary Profiles in Relation to Dental Caries and Obesity |
|---|---|
| Authors | |
| Issue Date | 25-Jun-2025 |
| Publisher | SAGE Publications |
| Abstract | Objectives: Research suggests that obese individuals are prone to dental caries, hypothesizing that it is due to adipose tissue's impact on salivary gland function. This study investigated the association between salivary characteristics, dental caries, and central obesity among adolescents in Hong Kong. |
| Persistent Identifier | http://hdl.handle.net/10722/359475 |
| ISSN | 2023 Impact Factor: 5.7 2023 SCImago Journal Rankings: 1.909 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Peng, Simin | - |
| dc.contributor.author | Deng, Q | - |
| dc.contributor.author | Wong, Hai Ming | - |
| dc.date.accessioned | 2025-09-07T00:30:36Z | - |
| dc.date.available | 2025-09-07T00:30:36Z | - |
| dc.date.issued | 2025-06-25 | - |
| dc.identifier.issn | 0022-0345 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/359475 | - |
| dc.description.abstract | <p>Objectives: Research suggests that obese individuals are prone to dental caries, hypothesizing that it is due to adipose tissue's impact on salivary gland function. This study investigated the association between salivary characteristics, dental caries, and central obesity among adolescents in Hong Kong.<br>Methods: Adolescents aged 12 to 15 years were recruited for the study, undergoing height and weight measurements according to a standardized protocol, and oral examinations following World Health Organization criteria. The waist-to-height ratio (WHtR) was used to assess central obesity with specific Hong Kong Chinese cutoffs. The decayed, missing, and filled teeth (DMFT) index indicated dental caries. Participants were grouped based on sex and age into four categories: 1) normal WHtR without caries (NW+NC), 2) high WHtR without caries (HW+NC), 3) normal WHtR with caries (NW+C), and 4) high WHtR with caries (HW+C). Whole saliva specimens, both unstimulated and stimulated, were collected for analyzing salivary physicochemical parameters, and for quantifying lipoprotein-associated phospholipase A2 (Lp-PLA2), secretory phospholipase A2 group IIA (sPLA2-IIA), interleukin-6, and <em>S. mutans</em>.<br>Results: A total of 180 participants were enrolled in the study. Participants in the HW+NC, NW+C, and HW+C groups had significantly higher salivary Lp-PLA2 levels and significantly lower stimulated salivary flow rate than those in the NW+NC group. The NW+C and HW+C groups had significantly lower unstimulated salivary flow rate than the NW+NC group. The HW+C group demonstrated a significantly lower salivary sPLA2-IIA output than the NW+C and NW+NC groups. Salivary <em>S. mutans</em> levels were significantly higher in the HW+C group compared to the HW+NC and NW+NC groups, and in the NW+C group compared to the NW+NC group.<br>Conclusions: Adolescents presenting with concurrent central obesity and dental caries are prone to experiencing compromised salivary defense mechanisms. Analysis of salivary profiles offers insights into elucidating the mechanisms that underlie the oral implications of obesity.<br></p> | - |
| dc.language | eng | - |
| dc.publisher | SAGE Publications | - |
| dc.relation.ispartof | Journal of Dental Research | - |
| dc.title | Exploring Salivary Profiles in Relation to Dental Caries and Obesity | - |
| dc.type | Conference_Paper | - |
| dc.identifier.volume | 104 | - |
| dc.identifier.issue | Spec Iss B | - |
| dc.identifier.eissn | 1544-0591 | - |
| dc.identifier.issnl | 0022-0345 | - |