File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Altered Sensorimotor Striatal Network Connectivity in Women With Anorexia Nervosa

TitleAltered Sensorimotor Striatal Network Connectivity in Women With Anorexia Nervosa
Authors
Issue Date16-Jan-2025
PublisherWiley
Citation
European Eating Disorders Review, 2025 How to Cite?
Abstract

Objective

Anorexia nervosa (AN) is associated with disturbances in reward processing, cognitive control, and body image perception, implicating striatal dysfunction. Evidence suggests that underweight may modulate brain function in AN. We aimed to investigate whole-brain resting-state functional connectivity (rsFC) of the striatum in patients with AN while controlling for the acute effects of underweight.

Method

Using theoretically selected striatal sub-regions, whole-brain rsFC patterns of the striatum were compared among patients with AN (n = 39, BMI = 16.19 ± 1.48 kg/m2), normal weight healthy controls (NHC) (n = 31, BMI = 20.98 ± 1.72 kg/m2), and underweight healthy controls (UHC) (n = 22, BMI = 16.68 ± 0.69 kg/m2). Correlation analysis between rsFC and clinical measures was conducted for the patients with AN.

Results

Compared with the NHC group, AN patients showed increased striatal rsFC with the fronto-parietal network (FPN) and reduced striatal rsFC with sensorimotor and visual regions. Compared with the UHC group, AN patients exhibited reduced striatal rsFC solely with sensorimotor and visual regions. No significant correlations were found between striatal rsFC and clinical variables in the patients with AN.

Conclusion

Our findings suggest that decreased striatal rsFC with sensorimotor and visual areas may represent illness-specific neural correlates in patients with AN.


Persistent Identifierhttp://hdl.handle.net/10722/353799
ISSN
2023 Impact Factor: 3.9
2023 SCImago Journal Rankings: 1.256

 

DC FieldValueLanguage
dc.contributor.authorWang, Y-
dc.contributor.authorChu, M-
dc.contributor.authorWang, Y-
dc.contributor.authorLei, X-
dc.contributor.authorKang, Q-
dc.contributor.authorYue, L-
dc.contributor.authorChen, Y-
dc.contributor.authorLui, SSY-
dc.contributor.authorWang, Z-
dc.contributor.authorChan, RCK-
dc.contributor.authorChen, J-
dc.date.accessioned2025-01-24T00:35:55Z-
dc.date.available2025-01-24T00:35:55Z-
dc.date.issued2025-01-16-
dc.identifier.citationEuropean Eating Disorders Review, 2025-
dc.identifier.issn1072-4133-
dc.identifier.urihttp://hdl.handle.net/10722/353799-
dc.description.abstract<h3>Objective</h3><p>Anorexia nervosa (AN) is associated with disturbances in reward processing, cognitive control, and body image perception, implicating striatal dysfunction. Evidence suggests that underweight may modulate brain function in AN. We aimed to investigate whole-brain resting-state functional connectivity (rsFC) of the striatum in patients with AN while controlling for the acute effects of underweight.</p><h3>Method</h3><p>Using theoretically selected striatal sub-regions, whole-brain rsFC patterns of the striatum were compared among patients with AN (<em>n</em> = 39, BMI = 16.19 ± 1.48 kg/m<sup>2</sup>), normal weight healthy controls (NHC) (<em>n</em> = 31, BMI = 20.98 ± 1.72 kg/m<sup>2</sup>), and underweight healthy controls (UHC) (<em>n</em> = 22, BMI = 16.68 ± 0.69 kg/m<sup>2</sup>). Correlation analysis between rsFC and clinical measures was conducted for the patients with AN.</p><h3>Results</h3><p>Compared with the NHC group, AN patients showed increased striatal rsFC with the fronto-parietal network (FPN) and reduced striatal rsFC with sensorimotor and visual regions. Compared with the UHC group, AN patients exhibited reduced striatal rsFC solely with sensorimotor and visual regions. No significant correlations were found between striatal rsFC and clinical variables in the patients with AN.</p><h3>Conclusion</h3><p>Our findings suggest that decreased striatal rsFC with sensorimotor and visual areas may represent illness-specific neural correlates in patients with AN.</p>-
dc.languageeng-
dc.publisherWiley-
dc.relation.ispartofEuropean Eating Disorders Review-
dc.titleAltered Sensorimotor Striatal Network Connectivity in Women With Anorexia Nervosa-
dc.typeArticle-
dc.identifier.doi10.1002/erv.3172-
dc.identifier.eissn1099-0968-
dc.identifier.issnl1072-4133-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats