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Article: Reduced bone mineral density in patients with idiopathic inflammatory myopathies: a case-control study

TitleReduced bone mineral density in patients with idiopathic inflammatory myopathies: a case-control study
Authors
Tang, IYKLuk, LWong, VPang, SLao, VSo, H
Keywordsbone mineral density
idiopathic inflammatory myopathy
osteopenia
osteoporosis
Issue Date16-Jul-2023
PublisherSAGE Publications
Citation
Therapeutic Advances in Musculoskeletal Disease, 2023, v. 15, p. 1-11 How to Cite?
DOI: http://dx.doi.org/10.1177/1759720X231181968
Abstract

Background:

Patients with idiopathic inflammatory myopathies (IIMs) are at risk of reduced bone mineral density (BMD).

Objectives:

To compare the prevalence of reduced BMD between patients with IIMs and controls and to determine its risk factors.

Design:

This was a single-center case-control study.

Methods:

BMD was assessed by dual-energy X-ray absorptiometry. The prevalence of reduced BMD in IIM patients and age-and sex-matched non-rheumatological controls was compared. The BMD results of female IIM were also compared to age-matched female rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients. Independent factors associated with reduced BMD in IIM patients were identified by multivariate analyses.

Results:

A total of 230 patients (IIM: 65, non-rheumatological controls: 65, RA: 50, SLE: 50) were recruited. The mean age of IIM patients was 58.6 ± 11.0 years and 76.9% were females. Significantly, more IIM patients had reduced BMD (73.8% versus 43.1%, p = 0.043) and osteoporosis (29.2% versus 13.8%, p = 0.033) than non-rheumatological controls. Multivariate analysis confirmed that IIM was independently associated with reduced BMD (OR: 2.12, p = 0.048, 95% CI: 1.01–4.46). The prevalence of reduced BMD was not significantly different between IIM, RA, and SLE patients but the mean hip BMD was the lowest in the IIM group (0.641 ± 0.152 g/cm2 versus 0.663 ± 0.102g/cm2 in the RA group versus 0.708 ± 0.132 g/cm2 in the SLE group, p = 0.035). Lower body mass index and more advanced age were independently associated with lower BMD in IIM patients.

Conclusion:

Reduced BMD was more prevalent in IIM patients than in non-rheumatological controls. Hip BMD was lower in patients with IIMs than RA or SLE. Close monitoring and early treatment are encouraged especially in patients with risk factors.


Persistent Identifierhttp://hdl.handle.net/10722/351780
ISSN
1759-720X
2023 Impact Factor: 3.4
2023 SCImago Journal Rankings: 1.061
ISI Accession Number ID
WOS:001027445600001

 

DC FieldValueLanguage
dc.contributor.authorTang, IYK-
dc.contributor.authorLuk, L-
dc.contributor.authorWong, V-
dc.contributor.authorPang, S-
dc.contributor.authorLao, V-
dc.contributor.authorSo, H-
dc.date.accessioned2024-11-28T00:35:12Z-
dc.date.available2024-11-28T00:35:12Z-
dc.date.issued2023-07-16-
dc.identifier.citationTherapeutic Advances in Musculoskeletal Disease, 2023, v. 15, p. 1-11-
dc.identifier.issn1759-720X-
dc.identifier.urihttp://hdl.handle.net/10722/351780-
dc.description.abstract<h3>Background:</h3><p>Patients with idiopathic inflammatory myopathies (IIMs) are at risk of reduced bone mineral density (BMD).</p><h3>Objectives:</h3><p>To compare the prevalence of reduced BMD between patients with IIMs and controls and to determine its risk factors.</p><h3>Design:</h3><p>This was a single-center case-control study.</p><h3>Methods:</h3><p>BMD was assessed by dual-energy X-ray absorptiometry. The prevalence of reduced BMD in IIM patients and age-and sex-matched non-rheumatological controls was compared. The BMD results of female IIM were also compared to age-matched female rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients. Independent factors associated with reduced BMD in IIM patients were identified by multivariate analyses.</p><h3>Results:</h3><p>A total of 230 patients (IIM: 65, non-rheumatological controls: 65, RA: 50, SLE: 50) were recruited. The mean age of IIM patients was 58.6 ± 11.0 years and 76.9% were females. Significantly, more IIM patients had reduced BMD (73.8% <em>versus</em> 43.1%, <em>p</em> = 0.043) and osteoporosis (29.2% <em>versus</em> 13.8%, <em>p</em> = 0.033) than non-rheumatological controls. Multivariate analysis confirmed that IIM was independently associated with reduced BMD (OR: 2.12, <em>p</em> = 0.048, 95% CI: 1.01–4.46). The prevalence of reduced BMD was not significantly different between IIM, RA, and SLE patients but the mean hip BMD was the lowest in the IIM group (0.641 ± 0.152 g/cm2 <em>versus</em> 0.663 ± 0.102g/cm2 in the RA group <em>versus</em> 0.708 ± 0.132 g/cm2 in the SLE group, <em>p</em> = 0.035). Lower body mass index and more advanced age were independently associated with lower BMD in IIM patients.</p><h3>Conclusion:</h3><p>Reduced BMD was more prevalent in IIM patients than in non-rheumatological controls. Hip BMD was lower in patients with IIMs than RA or SLE. Close monitoring and early treatment are encouraged especially in patients with risk factors.</p>-
dc.languageeng-
dc.publisherSAGE Publications-
dc.relation.ispartofTherapeutic Advances in Musculoskeletal Disease-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectbone mineral density-
dc.subjectidiopathic inflammatory myopathy-
dc.subjectosteopenia-
dc.subjectosteoporosis-
dc.titleReduced bone mineral density in patients with idiopathic inflammatory myopathies: a case-control study-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1177/1759720X231181968-
dc.identifier.scopuseid_2-s2.0-85165008649-
dc.identifier.volume15-
dc.identifier.spage1-
dc.identifier.epage11-
dc.identifier.eissn1759-7218-
dc.identifier.isiWOS:001027445600001-
dc.identifier.issnl1759-720X-

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