File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.3390/biology13010013
- Scopus: eid_2-s2.0-85190153002
Supplementary
-
Citations:
- Scopus: 0
- Appears in Collections:
Article: The Origin Recognition Complex: From Origin Selection to Replication Licensing in Yeast and Humans
| Title | The Origin Recognition Complex: From Origin Selection to Replication Licensing in Yeast and Humans |
|---|---|
| Authors | |
| Keywords | cryoEM structures eukaryotic DNA replication MCM hexamers Meier–Gorlin syndrome origin recognition complex origin selection replication initiation |
| Issue Date | 1-Jan-2024 |
| Publisher | MDPI |
| Citation | Biology, 2024, v. 13, n. 1 How to Cite? |
| Abstract | Understanding human DNA replication through the study of yeast has been an extremely fruitful journey. The minichromosome maintenance (MCM) 2–7 genes that encode the catalytic core of the eukaryotic replisome were initially identified through forward yeast genetics. The origin recognition complexes (ORC) that load the MCM hexamers at replication origins were purified from yeast extracts. We have reached an age where high-resolution cryoEM structures of yeast and human replication complexes can be compared side-by-side. Their similarities and differences are converging as alternative strategies that may deviate in detail but are shared by both species. |
| Persistent Identifier | http://hdl.handle.net/10722/351695 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Tye, Bik Kwoon | - |
| dc.contributor.author | Zhai, Yuanliang | - |
| dc.date.accessioned | 2024-11-22T00:35:12Z | - |
| dc.date.available | 2024-11-22T00:35:12Z | - |
| dc.date.issued | 2024-01-01 | - |
| dc.identifier.citation | Biology, 2024, v. 13, n. 1 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/351695 | - |
| dc.description.abstract | Understanding human DNA replication through the study of yeast has been an extremely fruitful journey. The minichromosome maintenance (MCM) 2–7 genes that encode the catalytic core of the eukaryotic replisome were initially identified through forward yeast genetics. The origin recognition complexes (ORC) that load the MCM hexamers at replication origins were purified from yeast extracts. We have reached an age where high-resolution cryoEM structures of yeast and human replication complexes can be compared side-by-side. Their similarities and differences are converging as alternative strategies that may deviate in detail but are shared by both species. | - |
| dc.language | eng | - |
| dc.publisher | MDPI | - |
| dc.relation.ispartof | Biology | - |
| dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
| dc.subject | cryoEM structures | - |
| dc.subject | eukaryotic DNA replication | - |
| dc.subject | MCM hexamers | - |
| dc.subject | Meier–Gorlin syndrome | - |
| dc.subject | origin recognition complex | - |
| dc.subject | origin selection | - |
| dc.subject | replication initiation | - |
| dc.title | The Origin Recognition Complex: From Origin Selection to Replication Licensing in Yeast and Humans | - |
| dc.type | Article | - |
| dc.identifier.doi | 10.3390/biology13010013 | - |
| dc.identifier.scopus | eid_2-s2.0-85190153002 | - |
| dc.identifier.volume | 13 | - |
| dc.identifier.issue | 1 | - |
| dc.identifier.eissn | 2079-7737 | - |
| dc.identifier.issnl | 2079-7737 | - |