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- Publisher Website: 10.1039/d0bm01421d
- Scopus: eid_2-s2.0-85101127368
- PMID: 33206082
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Article: Green synthesis of methoxy-poly(ethylene glycol)-: Block-poly(l-lactide-co-glycolide) copolymer using zinc proline as a biocompatible initiator for irinotecan delivery to colon cancer in vivo
Title | Green synthesis of methoxy-poly(ethylene glycol)-: Block-poly(l-lactide-co-glycolide) copolymer using zinc proline as a biocompatible initiator for irinotecan delivery to colon cancer in vivo |
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Authors | |
Issue Date | 2021 |
Citation | Biomaterials Science, 2021, v. 9, n. 3, p. 795-806 How to Cite? |
Abstract | Poly(lactic-co-glycolic acid) (PLGA) is the most commonly described biocompatible copolymer used in biomedical applications. In this work, a green synthetic approach based on the biocompatible zinc proline complex, as an initiator for PLGA synthesis, is reported for the first time for the synthesis of methoxy-poly(ethylene glycol)-block-poly(l-lactic-co-glycolic acid) (mPEG-PLGA). mPEG-PLGA with controlled molecular weight and narrow polydispersity was synthesised. Its potential for delivery of irinotecan (Ir), a poorly water-soluble chemotherapeutic drug used for the treatment of colon and pancreatic cancer, was studied. Nanoparticles of controlled size (140-160 nm), surface charge (∼-10 mV), release properties and cytotoxicity against CT-26 (colon) and BxPC-3 (pancreatic) cancer cells, were prepared. Tumor accumulation was confirmed by optical imaging of fluorescently labelled nanoparticles. Unlike Tween® 80 coated NP-Ir, the Pluronic® F-127 coated NP-Ir exhibits significant tumor growth delay compared to untreated and blank formulation treated groups in the CT-26 subcutaneous tumor model, after 4 treatments of 30 mg irinotecan per kg dose. Overall, this proof-of-concept study demonstrates that the newly synthesized copolymer, via a green route, is proven to be nontoxic, requires fewer purification steps and has potential applications in drug delivery. |
Persistent Identifier | http://hdl.handle.net/10722/349532 |
ISSN | 2023 Impact Factor: 5.8 2023 SCImago Journal Rankings: 1.206 |
DC Field | Value | Language |
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dc.contributor.author | Giram, Prabhanjan S. | - |
dc.contributor.author | Wang, Julie Tzu Wen | - |
dc.contributor.author | Walters, Adam A. | - |
dc.contributor.author | Rade, Priyanka P. | - |
dc.contributor.author | Akhtar, Muhammad | - |
dc.contributor.author | Han, Shunping | - |
dc.contributor.author | Faruqu, Farid N. | - |
dc.contributor.author | Abdel-Bar, Hend M. | - |
dc.contributor.author | Garnaik, Baijayantimala | - |
dc.contributor.author | Al-Jamal, Khuloud T. | - |
dc.date.accessioned | 2024-10-17T06:59:09Z | - |
dc.date.available | 2024-10-17T06:59:09Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Biomaterials Science, 2021, v. 9, n. 3, p. 795-806 | - |
dc.identifier.issn | 2047-4830 | - |
dc.identifier.uri | http://hdl.handle.net/10722/349532 | - |
dc.description.abstract | Poly(lactic-co-glycolic acid) (PLGA) is the most commonly described biocompatible copolymer used in biomedical applications. In this work, a green synthetic approach based on the biocompatible zinc proline complex, as an initiator for PLGA synthesis, is reported for the first time for the synthesis of methoxy-poly(ethylene glycol)-block-poly(l-lactic-co-glycolic acid) (mPEG-PLGA). mPEG-PLGA with controlled molecular weight and narrow polydispersity was synthesised. Its potential for delivery of irinotecan (Ir), a poorly water-soluble chemotherapeutic drug used for the treatment of colon and pancreatic cancer, was studied. Nanoparticles of controlled size (140-160 nm), surface charge (∼-10 mV), release properties and cytotoxicity against CT-26 (colon) and BxPC-3 (pancreatic) cancer cells, were prepared. Tumor accumulation was confirmed by optical imaging of fluorescently labelled nanoparticles. Unlike Tween® 80 coated NP-Ir, the Pluronic® F-127 coated NP-Ir exhibits significant tumor growth delay compared to untreated and blank formulation treated groups in the CT-26 subcutaneous tumor model, after 4 treatments of 30 mg irinotecan per kg dose. Overall, this proof-of-concept study demonstrates that the newly synthesized copolymer, via a green route, is proven to be nontoxic, requires fewer purification steps and has potential applications in drug delivery. | - |
dc.language | eng | - |
dc.relation.ispartof | Biomaterials Science | - |
dc.title | Green synthesis of methoxy-poly(ethylene glycol)-: Block-poly(l-lactide-co-glycolide) copolymer using zinc proline as a biocompatible initiator for irinotecan delivery to colon cancer in vivo | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1039/d0bm01421d | - |
dc.identifier.pmid | 33206082 | - |
dc.identifier.scopus | eid_2-s2.0-85101127368 | - |
dc.identifier.volume | 9 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 795 | - |
dc.identifier.epage | 806 | - |
dc.identifier.eissn | 2047-4849 | - |