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Article: Synthesis of double-clickable functionalised graphene oxide for biological applications

TitleSynthesis of double-clickable functionalised graphene oxide for biological applications
Authors
Mei, Kuo ChingRubio, NoeliaCosta, Pedro M.Kafa, HoumamAbbate, VincenzoFesty, FredericBansal, Sukhvinder S.Hider, Robert C.Al-Jamal, Khuloud T.
Issue Date2015
Citation
Chemical Communications, 2015, v. 51, n. 81, p. 14981-14984 How to Cite?
DOI: http://dx.doi.org/10.1039/c5cc05412e
AbstractAzide- and alkyne-double functionalised graphene oxide (Click2 GO) was synthesised and characterised with attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), thermogravimetric analysis (TGA) and Raman spectroscopy. Fourteen-percentage increase in azide content was found, after pre-treatment of GO with meta-chloroperoxybenzoic acid (mCPBA), determined with elemental analysis. No effect on A549 cell viability was found, up to 100 μg mL-1 and 72 h of incubation, determined with the modified lactate dehydrogenase (mLDH) assay. Two sequential copper(i) catalysed azide-alkyne cycloaddition (CuAAC) reactions were performed to conjugate the propargyl-modified blood-brain barrier targeting peptide Angiopep-2, and a bis-azide polyethylene glycol (MW = 3500), to the Click2 GO. The final conjugate was characterised with ATR-FTIR and TGA.
Persistent Identifierhttp://hdl.handle.net/10722/349085
ISSN
1359-7345
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 1.133

 

DC FieldValueLanguage
dc.contributor.authorMei, Kuo Ching-
dc.contributor.authorRubio, Noelia-
dc.contributor.authorCosta, Pedro M.-
dc.contributor.authorKafa, Houmam-
dc.contributor.authorAbbate, Vincenzo-
dc.contributor.authorFesty, Frederic-
dc.contributor.authorBansal, Sukhvinder S.-
dc.contributor.authorHider, Robert C.-
dc.contributor.authorAl-Jamal, Khuloud T.-
dc.date.accessioned2024-10-17T06:56:10Z-
dc.date.available2024-10-17T06:56:10Z-
dc.date.issued2015-
dc.identifier.citationChemical Communications, 2015, v. 51, n. 81, p. 14981-14984-
dc.identifier.issn1359-7345-
dc.identifier.urihttp://hdl.handle.net/10722/349085-
dc.description.abstractAzide- and alkyne-double functionalised graphene oxide (Click2 GO) was synthesised and characterised with attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), thermogravimetric analysis (TGA) and Raman spectroscopy. Fourteen-percentage increase in azide content was found, after pre-treatment of GO with meta-chloroperoxybenzoic acid (mCPBA), determined with elemental analysis. No effect on A549 cell viability was found, up to 100 μg mL-1 and 72 h of incubation, determined with the modified lactate dehydrogenase (mLDH) assay. Two sequential copper(i) catalysed azide-alkyne cycloaddition (CuAAC) reactions were performed to conjugate the propargyl-modified blood-brain barrier targeting peptide Angiopep-2, and a bis-azide polyethylene glycol (MW = 3500), to the Click2 GO. The final conjugate was characterised with ATR-FTIR and TGA.-
dc.languageeng-
dc.relation.ispartofChemical Communications-
dc.titleSynthesis of double-clickable functionalised graphene oxide for biological applications-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/c5cc05412e-
dc.identifier.pmid26295072-
dc.identifier.scopuseid_2-s2.0-84940854771-
dc.identifier.volume51-
dc.identifier.issue81-
dc.identifier.spage14981-
dc.identifier.epage14984-
dc.identifier.eissn1364-548X-

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