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Conference Paper: Natural leaf replicas to study cell contact guidance

TitleNatural leaf replicas to study cell contact guidance
Authors
Macqueen, LukeGong, ZhengChen, BrandonLiu, JunLiu, HaijiaoSimmons, CraigSun, Yu
KeywordsBiomimicry
Contact guidance
Leaf
Vasculature
Venation
Issue Date2013
Citation
17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, 2013, v. 3, p. 1917-1919 How to Cite?
AbstractWe describe a method to fabricate cell culture substrates with multi-scale branching topographies that mimic reticulated venation. By replicating the structure of natural leaves in silicone sheets and using these as templates for cell culture substrates, we performed heuristic studies of cell responses to multi-scale topographical features. Cultured human multipotent stromal/stem cells (hMSC) and GFP-transfected retinal pigment epithelial (ARPE) cell morphologies were guided by the underlying substrate by forming branched networks. Cell nuclei were aligned on branches and elongated by factors of 1.8 (MSC) or 1.7 (ARPE) with respect to off-branch nuclei.
Persistent Identifierhttp://hdl.handle.net/10722/349043

 

DC FieldValueLanguage
dc.contributor.authorMacqueen, Luke-
dc.contributor.authorGong, Zheng-
dc.contributor.authorChen, Brandon-
dc.contributor.authorLiu, Jun-
dc.contributor.authorLiu, Haijiao-
dc.contributor.authorSimmons, Craig-
dc.contributor.authorSun, Yu-
dc.date.accessioned2024-10-17T06:55:53Z-
dc.date.available2024-10-17T06:55:53Z-
dc.date.issued2013-
dc.identifier.citation17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, 2013, v. 3, p. 1917-1919-
dc.identifier.urihttp://hdl.handle.net/10722/349043-
dc.description.abstractWe describe a method to fabricate cell culture substrates with multi-scale branching topographies that mimic reticulated venation. By replicating the structure of natural leaves in silicone sheets and using these as templates for cell culture substrates, we performed heuristic studies of cell responses to multi-scale topographical features. Cultured human multipotent stromal/stem cells (hMSC) and GFP-transfected retinal pigment epithelial (ARPE) cell morphologies were guided by the underlying substrate by forming branched networks. Cell nuclei were aligned on branches and elongated by factors of 1.8 (MSC) or 1.7 (ARPE) with respect to off-branch nuclei.-
dc.languageeng-
dc.relation.ispartof17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013-
dc.subjectBiomimicry-
dc.subjectContact guidance-
dc.subjectLeaf-
dc.subjectVasculature-
dc.subjectVenation-
dc.titleNatural leaf replicas to study cell contact guidance-
dc.typeConference_Paper-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-84907329982-
dc.identifier.volume3-
dc.identifier.spage1917-
dc.identifier.epage1919-

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