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- Publisher Website: 10.1038/micronano.2015.20
- Scopus: eid_2-s2.0-84991696347
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Article: Voyage inside the cell: Microsystems and nanoengineering for intracellular measurement and manipulation
Title | Voyage inside the cell: Microsystems and nanoengineering for intracellular measurement and manipulation |
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Authors | |
Keywords | Atomic force microscopy (AFM) Fluorescent proteins and molecules Intracellular manipulation Intracellular measurement MEMS Nanoparticle Nanotube Nanowire |
Issue Date | 14-Sep-2015 |
Publisher | Springer Nature |
Citation | Microsystems and Nanoengineering, 2015, v. 1 How to Cite? |
Abstract | Properties of organelles and intracellular structures play important roles in regulating cellular functions, such as gene expression, cell motility and metabolism. The ability to directly interrogate intracellular structures inside a single cell for measurement and manipulation has significant implications in the understanding of subcellular and suborganelle activities, diagnosing diseases, and potentially developing new therapeutic approaches. In the past few decades, a number of technologies have been developed to study single-cell properties. However, methods of measuring intracellular properties and manipulating subcellular structures have been largely underexplored. Due to the even smaller size of intracellular targets and lower signal-to-noise ratio than that in whole-cell studies, the development of tools for intracellular measurement and manipulation is challenging. This paper reviews emerging microsystems and nanoengineered technologies for sensing and quantitative measurement of intracellular properties and for manipulating structures inside a single cell. Recent progress and limitations of these new technologies as well as new discoveries and prospects are discussed. |
Persistent Identifier | http://hdl.handle.net/10722/348767 |
ISSN | 2023 Impact Factor: 7.3 2023 SCImago Journal Rankings: 1.626 |
DC Field | Value | Language |
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dc.contributor.author | Liu, J | - |
dc.contributor.author | Wen, J | - |
dc.contributor.author | Zhang, Z | - |
dc.contributor.author | Liu, H | - |
dc.contributor.author | Sun, Y | - |
dc.date.accessioned | 2024-10-15T00:30:41Z | - |
dc.date.available | 2024-10-15T00:30:41Z | - |
dc.date.issued | 2015-09-14 | - |
dc.identifier.citation | Microsystems and Nanoengineering, 2015, v. 1 | - |
dc.identifier.issn | 2055-7434 | - |
dc.identifier.uri | http://hdl.handle.net/10722/348767 | - |
dc.description.abstract | <p>Properties of organelles and intracellular structures play important roles in regulating cellular functions, such as gene expression, cell motility and metabolism. The ability to directly interrogate intracellular structures inside a single cell for measurement and manipulation has significant implications in the understanding of subcellular and suborganelle activities, diagnosing diseases, and potentially developing new therapeutic approaches. In the past few decades, a number of technologies have been developed to study single-cell properties. However, methods of measuring intracellular properties and manipulating subcellular structures have been largely underexplored. Due to the even smaller size of intracellular targets and lower signal-to-noise ratio than that in whole-cell studies, the development of tools for intracellular measurement and manipulation is challenging. This paper reviews emerging microsystems and nanoengineered technologies for sensing and quantitative measurement of intracellular properties and for manipulating structures inside a single cell. Recent progress and limitations of these new technologies as well as new discoveries and prospects are discussed.<br></p> | - |
dc.language | eng | - |
dc.publisher | Springer Nature | - |
dc.relation.ispartof | Microsystems and Nanoengineering | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Atomic force microscopy (AFM) | - |
dc.subject | Fluorescent proteins and molecules | - |
dc.subject | Intracellular manipulation | - |
dc.subject | Intracellular measurement | - |
dc.subject | MEMS | - |
dc.subject | Nanoparticle | - |
dc.subject | Nanotube | - |
dc.subject | Nanowire | - |
dc.title | Voyage inside the cell: Microsystems and nanoengineering for intracellular measurement and manipulation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/micronano.2015.20 | - |
dc.identifier.scopus | eid_2-s2.0-84991696347 | - |
dc.identifier.volume | 1 | - |
dc.identifier.issnl | 2055-7434 | - |