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- Publisher Website: 10.3390/ijms25041978
- Scopus: eid_2-s2.0-85185979302
- PMID: 38396653
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Article: Endothelial Senescence: From Macro- to Micro-Vasculature and Its Implications on Cardiovascular Health
Title | Endothelial Senescence: From Macro- to Micro-Vasculature and Its Implications on Cardiovascular Health |
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Authors | |
Keywords | endothelial cells microcirculation senescence senolytics |
Issue Date | 1-Feb-2024 |
Publisher | Multidisciplinary Digital Publishing Institute (MDPI) |
Citation | International Journal of Molecular Sciences, 2024, v. 25, n. 4 How to Cite? |
Abstract | Endothelial cells line at the most inner layer of blood vessels. They act to control hemostasis, arterial tone/reactivity, wound healing, tissue oxygen, and nutrient supply. With age, endothelial cells become senescent, characterized by reduced regeneration capacity, inflammation, and abnormal secretory profile. Endothelial senescence represents one of the earliest features of arterial ageing and contributes to many age-related diseases. Compared to those in arteries and veins, endothelial cells of the microcirculation exhibit a greater extent of heterogeneity. Microcirculatory endothelial senescence leads to a declined capillary density, reduced angiogenic potentials, decreased blood flow, impaired barrier properties, and hypoperfusion in a tissue or organ-dependent manner. The heterogeneous phenotypes of microvascular endothelial cells in a particular vascular bed and across different tissues remain largely unknown. Accordingly, the mechanisms underlying macro- and micro-vascular endothelial senescence vary in different pathophysiological conditions, thus offering specific target(s) for therapeutic development of senolytic drugs. |
Persistent Identifier | http://hdl.handle.net/10722/348495 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.179 |
DC Field | Value | Language |
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dc.contributor.author | Wang, Peichun | - |
dc.contributor.author | Konja, Daniels | - |
dc.contributor.author | Singh, Sandeep | - |
dc.contributor.author | Zhang, Beijia | - |
dc.contributor.author | Wang, Yu | - |
dc.date.accessioned | 2024-10-10T00:31:04Z | - |
dc.date.available | 2024-10-10T00:31:04Z | - |
dc.date.issued | 2024-02-01 | - |
dc.identifier.citation | International Journal of Molecular Sciences, 2024, v. 25, n. 4 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/10722/348495 | - |
dc.description.abstract | Endothelial cells line at the most inner layer of blood vessels. They act to control hemostasis, arterial tone/reactivity, wound healing, tissue oxygen, and nutrient supply. With age, endothelial cells become senescent, characterized by reduced regeneration capacity, inflammation, and abnormal secretory profile. Endothelial senescence represents one of the earliest features of arterial ageing and contributes to many age-related diseases. Compared to those in arteries and veins, endothelial cells of the microcirculation exhibit a greater extent of heterogeneity. Microcirculatory endothelial senescence leads to a declined capillary density, reduced angiogenic potentials, decreased blood flow, impaired barrier properties, and hypoperfusion in a tissue or organ-dependent manner. The heterogeneous phenotypes of microvascular endothelial cells in a particular vascular bed and across different tissues remain largely unknown. Accordingly, the mechanisms underlying macro- and micro-vascular endothelial senescence vary in different pathophysiological conditions, thus offering specific target(s) for therapeutic development of senolytic drugs. | - |
dc.language | eng | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.relation.ispartof | International Journal of Molecular Sciences | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | endothelial cells | - |
dc.subject | microcirculation | - |
dc.subject | senescence | - |
dc.subject | senolytics | - |
dc.title | Endothelial Senescence: From Macro- to Micro-Vasculature and Its Implications on Cardiovascular Health | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ijms25041978 | - |
dc.identifier.pmid | 38396653 | - |
dc.identifier.scopus | eid_2-s2.0-85185979302 | - |
dc.identifier.volume | 25 | - |
dc.identifier.issue | 4 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.issnl | 1422-0067 | - |