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- Publisher Website: 10.1016/j.cej.2024.151290
- Scopus: eid_2-s2.0-85190866581
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Article: A quantitative electrodiffusion model of antibacterial heavy metals: Ion influx through hydrophilic pores
Title | A quantitative electrodiffusion model of antibacterial heavy metals: Ion influx through hydrophilic pores |
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Authors | |
Keywords | Antibacterial mechanism Electrodiffusion model Heavy-metal ions Hydrophilic pore Osmotic pressure Transmembrane potential |
Issue Date | 1-Jun-2024 |
Publisher | Elsevier |
Citation | Chemical Engineering Journal, 2024, v. 489 How to Cite? |
Abstract | Excessive heavy-metal ions in the cytoplasm, being toxic ions, can inactivate bacteria, which has been widely used as an effective antibacterial method. Nevertheless, how such toxic ions can be transported into bacteria is poorly understood. Here, we discovered a new mechanism showing that toxic ions electro-diffuse into the cytoplasm through the inherent hydrophilic pores in the cell membrane of living bacteria. Transmembrane potential induces recoverable defects by enhancing the thermal fluctuation of phospholipid molecules. By integrating electroporation, surface potential, and cell osmotic pressure, we develop a simple model for the influx rate of heavy metal ions into living bacteria. Our modeling results agree well with the experimental ones on the survival rates of Gram-negative and Gram-positive bacteria. |
Persistent Identifier | http://hdl.handle.net/10722/348128 |
ISSN | 2023 Impact Factor: 13.3 2023 SCImago Journal Rankings: 2.852 |
DC Field | Value | Language |
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dc.contributor.author | Ma, JX | - |
dc.contributor.author | Huang, MX | - |
dc.date.accessioned | 2024-10-05T00:30:42Z | - |
dc.date.available | 2024-10-05T00:30:42Z | - |
dc.date.issued | 2024-06-01 | - |
dc.identifier.citation | Chemical Engineering Journal, 2024, v. 489 | - |
dc.identifier.issn | 1385-8947 | - |
dc.identifier.uri | http://hdl.handle.net/10722/348128 | - |
dc.description.abstract | <p>Excessive heavy-metal ions in the cytoplasm, being toxic ions, can inactivate bacteria, which has been widely used as an effective antibacterial method. Nevertheless, how such toxic ions can be transported into bacteria is poorly understood. Here, we discovered a new mechanism showing that toxic ions electro-diffuse into the cytoplasm through the inherent hydrophilic pores in the cell membrane of living bacteria. Transmembrane potential induces recoverable defects by enhancing the thermal fluctuation of phospholipid molecules. By integrating electroporation, surface potential, and cell osmotic pressure, we develop a simple model for the influx rate of heavy metal ions into living bacteria. Our modeling results agree well with the experimental ones on the survival rates of Gram-negative and Gram-positive bacteria.</p> | - |
dc.language | eng | - |
dc.publisher | Elsevier | - |
dc.relation.ispartof | Chemical Engineering Journal | - |
dc.subject | Antibacterial mechanism | - |
dc.subject | Electrodiffusion model | - |
dc.subject | Heavy-metal ions | - |
dc.subject | Hydrophilic pore | - |
dc.subject | Osmotic pressure | - |
dc.subject | Transmembrane potential | - |
dc.title | A quantitative electrodiffusion model of antibacterial heavy metals: Ion influx through hydrophilic pores | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.cej.2024.151290 | - |
dc.identifier.scopus | eid_2-s2.0-85190866581 | - |
dc.identifier.volume | 489 | - |
dc.identifier.eissn | 1873-3212 | - |
dc.identifier.issnl | 1385-8947 | - |