File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Tissue-Resident Memory T Cell: Ontogenetic Cellular Mechanism and Clinical Translation

TitleTissue-Resident Memory T Cell: Ontogenetic Cellular Mechanism and Clinical Translation
Authors
Xu, HaoranZhou, RunhongChen, Zhiwei
Keywordsimmunotherapy
mucosal immunity
T-cell differentiation
tissue-resident memory T cell
vaccine
Issue Date16-Aug-2023
PublisherOxford University Press
Citation
Clinical & Experimental Immunology, 2023, v. 214, n. 3, p. 249-259 How to Cite?
DOI: http://dx.doi.org/10.1093/cei/uxad090
AbstractMounting evidence has indicated the essential role of tissue-resident memory T (TRM) cells for frontline protection against viral infection and for cancer immune surveillance (Mueller SN, Mackay LK. Tissue-resident memory T cells: local specialists in immune defense. Nat Rev Immunol 2016, 16, 79–89. doi:10.1038/nri.2015.3.). TRM cells are transcriptionally, phenotypically, and functionally distinct from circulating memory T (Tcirm) cells. It is necessary to understand the unique ontogenetic mechanism, migratory regulation, and biological function of TRM cells. In this review, we discuss recent insights into cellular mechanisms and discrete responsiveness in different tissue microenvironments underlying TRM cell development. We also emphasize the translational potential of TRM cells by focusing on their establishment in association with improved protection in mucosal tissues against various types of diseases and effective strategies for eliciting TRM cells in both pre-clinical and clinical studies.
Persistent Identifierhttp://hdl.handle.net/10722/347993
ISSN
0009-9104
2023 Impact Factor: 3.4
2023 SCImago Journal Rankings: 1.114

 

DC FieldValueLanguage
dc.contributor.authorXu, Haoran-
dc.contributor.authorZhou, Runhong-
dc.contributor.authorChen, Zhiwei-
dc.date.accessioned2024-10-04T00:30:48Z-
dc.date.available2024-10-04T00:30:48Z-
dc.date.issued2023-08-16-
dc.identifier.citationClinical & Experimental Immunology, 2023, v. 214, n. 3, p. 249-259-
dc.identifier.issn0009-9104-
dc.identifier.urihttp://hdl.handle.net/10722/347993-
dc.description.abstractMounting evidence has indicated the essential role of tissue-resident memory T (TRM) cells for frontline protection against viral infection and for cancer immune surveillance (Mueller SN, Mackay LK. Tissue-resident memory T cells: local specialists in immune defense. Nat Rev Immunol 2016, 16, 79–89. doi:10.1038/nri.2015.3.). TRM cells are transcriptionally, phenotypically, and functionally distinct from circulating memory T (Tcirm) cells. It is necessary to understand the unique ontogenetic mechanism, migratory regulation, and biological function of TRM cells. In this review, we discuss recent insights into cellular mechanisms and discrete responsiveness in different tissue microenvironments underlying TRM cell development. We also emphasize the translational potential of TRM cells by focusing on their establishment in association with improved protection in mucosal tissues against various types of diseases and effective strategies for eliciting TRM cells in both pre-clinical and clinical studies.-
dc.languageeng-
dc.publisherOxford University Press-
dc.relation.ispartofClinical & Experimental Immunology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectimmunotherapy-
dc.subjectmucosal immunity-
dc.subjectT-cell differentiation-
dc.subjecttissue-resident memory T cell-
dc.subjectvaccine-
dc.titleTissue-Resident Memory T Cell: Ontogenetic Cellular Mechanism and Clinical Translation -
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1093/cei/uxad090-
dc.identifier.pmid37586053-
dc.identifier.scopuseid_2-s2.0-85179855676-
dc.identifier.volume214-
dc.identifier.issue3-
dc.identifier.spage249-
dc.identifier.epage259-
dc.identifier.eissn1365-2249-
dc.identifier.issnl0009-9104-

Export via OAI-PMH Interface in XML Formats

OR

Export to Other Non-XML Formats