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- Publisher Website: 10.1073/pnas.2318265121
- Scopus: eid_2-s2.0-85183469072
- PMID: 38261618
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Article: Intratumor injected gold molecular clusters for NIR-II imaging and cancer therapy
Title | Intratumor injected gold molecular clusters for NIR-II imaging and cancer therapy |
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Authors | |
Keywords | gold nanoclusters imaging-guided surgery molecular imaging of apoptosis NIR-II imaging photothermal therapy |
Issue Date | 1-Jan-2024 |
Publisher | National Academy of Sciences |
Citation | Proceedings of the National Academy of Sciences, 2024, v. 121, n. 5 How to Cite? |
Abstract | Surgical resections of solid tumors guided by visual inspection of tumor margins have been performed for over a century to treat cancer. Near-infrared (NIR) fluorescence labeling/imaging of tumor in the NIR-I (800 to 900 nm) range with systemically administrated fluorophore/tumor-targeting antibody conjugates have been introduced to improve tumor margin delineation, tumor removal accuracy, and patient survival. Here, we show Au25 molecular clusters functionalized with phosphorylcholine ligands (AuPC, ∼2 nm in size) as a preclinical intratumorally injectable agent for NIR-II/ SWIR (1,000 to 3,000 nm) fluorescence imaging-guided tumor resection. The AuPC clusters were found to be uniformly distributed in the 4T1 murine breast cancer tumor upon intratumor (i.t.) injection. The phosphocholine coating afforded highly stealth clusters, allowing a high percentage of AuPC to fill the tumor interstitial fluid space homogeneously. Intra-operative surgical navigation guided by imaging of the NIR-II fluorescence of AuPC allowed for complete and non-excessive tumor resection. The AuPC in tumors were also employed as a photothermal therapy (PTT) agent to uniformly heat up and eradicate tumors. Further, we performed in vivo NIR-IIb (1,500 to 1,700 nm) molecular imaging of the treated tumor using a quantum dot-Annexin V (QD-P3 -Anx V) conjugate, revealing cancer cell apoptosis following PTT. The therapeutic functionalities of AuPC clusters combined with rapid renal excretion, high biocompatibility, and safety make them promising for clinical translation. |
Persistent Identifier | http://hdl.handle.net/10722/347880 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 3.737 |
DC Field | Value | Language |
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dc.contributor.author | Baghdasaryan, Ani | - |
dc.contributor.author | Liu, Haoran | - |
dc.contributor.author | Ren, Fuqiang | - |
dc.contributor.author | Hsu, Ru Siou | - |
dc.contributor.author | Jiang, Yingying | - |
dc.contributor.author | Wang, Feifei | - |
dc.contributor.author | Zhang, Mengzhen | - |
dc.contributor.author | Grigoryan, Lilit | - |
dc.contributor.author | Dai, Hongjie | - |
dc.date.accessioned | 2024-10-02T06:25:10Z | - |
dc.date.available | 2024-10-02T06:25:10Z | - |
dc.date.issued | 2024-01-01 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences, 2024, v. 121, n. 5 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10722/347880 | - |
dc.description.abstract | Surgical resections of solid tumors guided by visual inspection of tumor margins have been performed for over a century to treat cancer. Near-infrared (NIR) fluorescence labeling/imaging of tumor in the NIR-I (800 to 900 nm) range with systemically administrated fluorophore/tumor-targeting antibody conjugates have been introduced to improve tumor margin delineation, tumor removal accuracy, and patient survival. Here, we show Au25 molecular clusters functionalized with phosphorylcholine ligands (AuPC, ∼2 nm in size) as a preclinical intratumorally injectable agent for NIR-II/ SWIR (1,000 to 3,000 nm) fluorescence imaging-guided tumor resection. The AuPC clusters were found to be uniformly distributed in the 4T1 murine breast cancer tumor upon intratumor (i.t.) injection. The phosphocholine coating afforded highly stealth clusters, allowing a high percentage of AuPC to fill the tumor interstitial fluid space homogeneously. Intra-operative surgical navigation guided by imaging of the NIR-II fluorescence of AuPC allowed for complete and non-excessive tumor resection. The AuPC in tumors were also employed as a photothermal therapy (PTT) agent to uniformly heat up and eradicate tumors. Further, we performed in vivo NIR-IIb (1,500 to 1,700 nm) molecular imaging of the treated tumor using a quantum dot-Annexin V (QD-P3 -Anx V) conjugate, revealing cancer cell apoptosis following PTT. The therapeutic functionalities of AuPC clusters combined with rapid renal excretion, high biocompatibility, and safety make them promising for clinical translation. | - |
dc.language | eng | - |
dc.publisher | National Academy of Sciences | - |
dc.relation.ispartof | Proceedings of the National Academy of Sciences | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | gold nanoclusters | - |
dc.subject | imaging-guided surgery | - |
dc.subject | molecular imaging of apoptosis | - |
dc.subject | NIR-II imaging | - |
dc.subject | photothermal therapy | - |
dc.title | Intratumor injected gold molecular clusters for NIR-II imaging and cancer therapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1073/pnas.2318265121 | - |
dc.identifier.pmid | 38261618 | - |
dc.identifier.scopus | eid_2-s2.0-85183469072 | - |
dc.identifier.volume | 121 | - |
dc.identifier.issue | 5 | - |
dc.identifier.eissn | 1091-6490 | - |
dc.identifier.issnl | 0027-8424 | - |