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- Publisher Website: 10.1039/d3tb01573d
- Scopus: eid_2-s2.0-85175052634
- PMID: 37818766
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Article: Design and fabrication of biomimicking radially graded scaffolds via digital light processing 3D printing for bone regeneration
Title | Design and fabrication of biomimicking radially graded scaffolds via digital light processing 3D printing for bone regeneration |
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Authors | |
Issue Date | 11-Oct-2023 |
Publisher | Royal Society of Chemistry |
Citation | Journal of Materials Chemistry B: Materials for biology and medicine, 2023, v. 11, n. 41, p. 9961-9974 How to Cite? |
Abstract | Scaffolds are an essential component in bone tissue engineering (BTE). However, most of the current BTE scaffolds are homogeneous structures and do not resemble the graded architectures of native bone. In the current study, four types of biomimicking scaffold designs based on gyroid (G) and primitive (P) units with radially graded pore sizes were devised, and scaffolds of these designs with two porosity groups (65 vol% and 75 vol%) were fabricated via digital light processing (DLP) 3D printing using biphasic calcium phosphate (BCP). Scaffolds of the gyroid-gyroid (G-G) design displayed better dimensional accuracy, compressive property, and cell proliferation rate than gyroid-primitive (G-P), primitive-gyroid (P-G), and primitive-primitive (P-P) scaffolds. Subsequently, graded G-G scaffolds with different porosities were fabricated and the relationship between compressive strength and porosity was determined. Furthermore, the sintered BCP bioceramics fabricated via current manufacturing process exhibited excellent biocompatibility and bioactivity, indicating their high potential for BTE. |
Persistent Identifier | http://hdl.handle.net/10722/347493 |
ISSN | 2023 Impact Factor: 6.1 2023 SCImago Journal Rankings: 1.216 |
DC Field | Value | Language |
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dc.contributor.author | Wang, Yue | - |
dc.contributor.author | Chen, Shangsi | - |
dc.contributor.author | Liang, Haowen | - |
dc.contributor.author | Bai, Jiaming | - |
dc.contributor.author | Wang, Min | - |
dc.date.accessioned | 2024-09-24T00:30:26Z | - |
dc.date.available | 2024-09-24T00:30:26Z | - |
dc.date.issued | 2023-10-11 | - |
dc.identifier.citation | Journal of Materials Chemistry B: Materials for biology and medicine, 2023, v. 11, n. 41, p. 9961-9974 | - |
dc.identifier.issn | 2050-750X | - |
dc.identifier.uri | http://hdl.handle.net/10722/347493 | - |
dc.description.abstract | <p>Scaffolds are an essential component in bone tissue engineering (BTE). However, most of the current BTE scaffolds are homogeneous structures and do not resemble the graded architectures of native bone. In the current study, four types of biomimicking scaffold designs based on gyroid (G) and primitive (P) units with radially graded pore sizes were devised, and scaffolds of these designs with two porosity groups (65 vol% and 75 vol%) were fabricated via digital light processing (DLP) 3D printing using biphasic calcium phosphate (BCP). Scaffolds of the gyroid-gyroid (G-G) design displayed better dimensional accuracy, compressive property, and cell proliferation rate than gyroid-primitive (G-P), primitive-gyroid (P-G), and primitive-primitive (P-P) scaffolds. Subsequently, graded G-G scaffolds with different porosities were fabricated and the relationship between compressive strength and porosity was determined. Furthermore, the sintered BCP bioceramics fabricated via current manufacturing process exhibited excellent biocompatibility and bioactivity, indicating their high potential for BTE.</p> | - |
dc.language | eng | - |
dc.publisher | Royal Society of Chemistry | - |
dc.relation.ispartof | Journal of Materials Chemistry B: Materials for biology and medicine | - |
dc.title | Design and fabrication of biomimicking radially graded scaffolds via digital light processing 3D printing for bone regeneration | - |
dc.type | Article | - |
dc.identifier.doi | 10.1039/d3tb01573d | - |
dc.identifier.pmid | 37818766 | - |
dc.identifier.scopus | eid_2-s2.0-85175052634 | - |
dc.identifier.volume | 11 | - |
dc.identifier.issue | 41 | - |
dc.identifier.spage | 9961 | - |
dc.identifier.epage | 9974 | - |
dc.identifier.eissn | 2050-7518 | - |
dc.identifier.issnl | 2050-750X | - |